Chapter 8 Towards the Molecular Mechanisms of Transgenerational Epigenetic Inheritance Insights from Transgenic Mice
Kaundal R, Yang Y, Nottoli T, Chi T. Chapter 8 Towards the Molecular Mechanisms of Transgenerational Epigenetic Inheritance Insights from Transgenic Mice. 2014, 75-85. DOI: 10.1016/b978-0-12-405944-3.00008-8.Peer-Reviewed Original ResearchTransgenerational epigenetic inheritanceChromatin marksChromatin modificationsEpigenetic inheritanceGlobal epigenetic reprogrammingTraditional transgenic miceCopy numberGene-targeting methodsSite-specific integrationMitotic inheritanceHeritable perturbationsEpigenetic reprogrammingTransgenerational inheritanceTractable systemEpigenetic modificationsUnderlying genesEpigenetic perturbationsCpG methylationTransgenic miceGenetic strategiesReporter geneCOL1A1 locusMolecular mechanismsSubsequent embryogenesisGermline transmission