2024
Ezrin drives adaptation of monocytes to the inflamed lung microenvironment
Gudneppanavar R, Di Pietro C, H Öz H, Zhang P, Cheng E, Huang P, Tebaldi T, Biancon G, Halene S, Hoppe A, Kim C, Gonzalez A, Krause D, Egan M, Gupta N, Murray T, Bruscia E. Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. Cell Death & Disease 2024, 15: 864. PMID: 39613751, PMCID: PMC11607083, DOI: 10.1038/s41419-024-07255-8.Peer-Reviewed Original ResearchConceptsActivation of focal adhesion kinaseExtracellular matrixActin-binding proteinsFocal adhesion kinaseLung extracellular matrixKnock-out mouse modelProtein kinase signalingCortical cytoskeletonLoss of ezrinKinase signalingPlasma membraneCell migrationSignaling pathwayEzrinResponse to lipopolysaccharideTissue-resident macrophagesMouse modelLipopolysaccharideCytoskeletonEzrin expressionLung microenvironmentKinaseMonocyte recruitmentProteinAktPersistent bloodstream infection in children: examining the role for repeat blood cultures
Puthawala C, Feinn R, Rivera-Viñas J, Lee H, Murray T, Peaper D. Persistent bloodstream infection in children: examining the role for repeat blood cultures. Journal Of Clinical Microbiology 2024, 62: e00998-24. PMID: 39365070, PMCID: PMC11559050, DOI: 10.1128/jcm.00998-24.Peer-Reviewed Original ResearchPositive blood culturesPersistent bloodstream infectionBlood culturesBloodstream infectionsCentral venous catheterPositive culturesVenous cathetersIndex blood cultureCross-sectional study of childrenRepeated blood culturesTime of blood drawElevated inflammatory markersAssociated with persistenceGt;48 hoursIndex cultureCross-sectional studyPersistent bacteremiaImmune dysfunctionPediatric patientsInflammatory markersDiagnostic stewardshipStudy of childrenPatient characteristicsClinical valueBlood drawCCR2+ monocytes are dispensable to resolve acute pulmonary Pseudomonas aeruginosa infections in WT and Cystic Fibrosis mice
Öz H, Braga C, Gudneppanavar R, Di Pietro C, Huang P, Zhang P, Krause D, Egan M, Murray T, Bruscia E. CCR2+ monocytes are dispensable to resolve acute pulmonary Pseudomonas aeruginosa infections in WT and Cystic Fibrosis mice. Journal Of Leukocyte Biology 2024, qiae218. PMID: 39365279, DOI: 10.1093/jleuko/qiae218.Peer-Reviewed Original ResearchLung tissue damageCystic fibrosisTissue damageMonocyte recruitmentImmune responsePulmonary Pseudomonas aeruginosa infectionHyper-inflammatory immune responseCystic fibrosis micePropagate tissue damagePseudomonas aeruginosaLungs of patientsChronic neutrophilic inflammationImmunological response to infectionHost immune responseMonocyte-derived macrophagesTarget monocyte recruitmentSite of injuryResponse to infectionCFTR modulatorsPA infectionChronic inflammatory disease conditionsReduced bactericidal activityAdjunctive therapyClinical outcomesEradicate infection395 Altered hematopoiesis and functional decline of hematopoietic stem cells in cystic fibrosis mice
Braga C, Mancuso R, Thompson E, Oez H, Gudneppannavar R, Zhang P, Huang P, Egan M, Murray T, Krause D, Bruscia E. 395 Altered hematopoiesis and functional decline of hematopoietic stem cells in cystic fibrosis mice. Journal Of Cystic Fibrosis 2024, 23: s207-s208. DOI: 10.1016/s1569-1993(24)01235-9.Peer-Reviewed Original ResearchBarriers to Effective Infection Prevention in the Neonatal Intensive Care Unit
Weser V, Crocker A, Murray T, Wright J, Truesdell E, Ciaburri R, Marks A, Martinello R, Hieftje K, Team H. Barriers to Effective Infection Prevention in the Neonatal Intensive Care Unit. Advances In Neonatal Care 2024, 24: 475-484. PMID: 39196970, DOI: 10.1097/anc.0000000000001195.Peer-Reviewed Original ResearchConceptsPatients' family membersInfection preventionFamily membersGroup of nursesReduce nurses’ burdenHand hygieneHospital-wide surveyIntensive care unitInductive content analysisDesign of educational interventionsCare unitNeonatal intensive care unitImprove patient outcomesEffective infection preventionHH educationNursing burdenEducational interventionFrontline staffHospital staffNeonatal nursesIP educationPatient's familyRisk of infection transmissionFocus groupsIP behaviorParticle size distribution of viable nebulized bacteriophage for the treatment of multi-drug resistant Pseudomonas aeruginosa
Thompson D, Semersky Z, Feinn R, Huang P, Turner P, Chan B, Koff J, Murray T. Particle size distribution of viable nebulized bacteriophage for the treatment of multi-drug resistant Pseudomonas aeruginosa. Respiratory Medicine And Research 2024, 86: 101133. PMID: 39121591, DOI: 10.1016/j.resmer.2024.101133.Peer-Reviewed Original ResearchYounger Age and Female Gender Are Associated With Delayed Antibiotics in Pediatric Sepsis
Kandil S, Lee S, Feinn R, Murray T. Younger Age and Female Gender Are Associated With Delayed Antibiotics in Pediatric Sepsis. Journal Of The Pediatric Infectious Diseases Society 2024, 13: 434-438. PMID: 38889196, DOI: 10.1093/jpids/piae064.Peer-Reviewed Original ResearchCharacterizing healthcare personnel attitudes toward receipt of a voluntary bivalent COVID-19 booster vaccine during a COVID-19 outbreak at a behavioral health hospital in Connecticut
Roberts S, Willebrand K, Fredrick J, Pischel L, Patel K, Murray T, Martinello R. Characterizing healthcare personnel attitudes toward receipt of a voluntary bivalent COVID-19 booster vaccine during a COVID-19 outbreak at a behavioral health hospital in Connecticut. Antimicrobial Stewardship & Healthcare Epidemiology 2024, 4: e87. PMID: 38774120, PMCID: PMC11106727, DOI: 10.1017/ash.2024.78.Peer-Reviewed Original ResearchChronic lung inflammation disrupts the quiescent state of hematopoietic stem cells in a cystic fibrosis mouse model
Braga C, Mancuso R, Thompson E, Oez H, Gudneppanavar R, Zhang P, Huang P, Murray T, Egan M, Krause D, Bruscia E. Chronic lung inflammation disrupts the quiescent state of hematopoietic stem cells in a cystic fibrosis mouse model. The Journal Of Immunology 2024, 212: 0062_6002-0062_6002. DOI: 10.4049/jimmunol.212.supp.0062.6002.Peer-Reviewed Original ResearchHematopoietic stem cellsChronic lung inflammationLung inflammationCystic fibrosisBone marrowQuiescent state of HSCsProgression of CF lung diseaseResponse to airway infectionWT hematopoietic stem cellsExpansion of HSCsMultipotent progenitorsCystic fibrosis mouse modelStem cellsCF lung diseasePathways associated with proliferationNeutrophilic lung inflammationPro-inflammatory signatureFibrosis mouse modelATAC-sequencing analysisAirway infectionBM cellsMyeloid lineageLung diseaseMouse modelInflammationEzrin drives adaptation of monocytes to the inflamed lung microenvironment.
Gudneppanavar R, Di Pietro C, Oez H, Zhang P, Huang P, Braga C, Tebaldi T, Biancon G, Kim C, Gonzalez A, Halene S, Krause D, Egan M, Gupta N, Murray T, Bruscia E. Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. The Journal Of Immunology 2024, 212: 0078_5418-0078_5418. DOI: 10.4049/jimmunol.212.supp.0078.5418.Peer-Reviewed Original ResearchRNA-seqActin-binding protein ezrinF-actin distributionImmune response to bacteriaCystic fibrosisIn vitro functional studiesResponse to bacteriaIncreased expression of pro-inflammatory markersCytoskeleton rearrangementF-actinResponse to lung infectionExpressed genesProtein ezrinTranscriptional profilesExpression of pro-inflammatory markersPlasma membranePro-inflammatory markersFunctional studiesEzrinLung extracellular matrixCF miceExtracellular matrixWT micePI3K/Akt signalingLung infectionThe diagnostic utility of obtaining two blood cultures for the diagnosis of early onset sepsis in neonates
Fleiss N, Shabanova V, Murray T, Gallagher P, Bizzarro M. The diagnostic utility of obtaining two blood cultures for the diagnosis of early onset sepsis in neonates. Journal Of Perinatology 2024, 44: 745-747. PMID: 38409330, DOI: 10.1038/s41372-024-01914-6.Peer-Reviewed Original Research
2023
1841. Younger age and female gender are associated with delayed antibiotics in pediatric sepsis
Kandil S, Lee S, Feinn R, Murray T. 1841. Younger age and female gender are associated with delayed antibiotics in pediatric sepsis. Open Forum Infectious Diseases 2023, 10: ofad500.1669. PMCID: PMC10678741, DOI: 10.1093/ofid/ofad500.1669.Peer-Reviewed Original ResearchAntibiotic administrationSepsis severityFemale genderNeonatal intensive care unitRetrospective cohort reviewDiagnosis of sepsisIntensive care unitExposure of interestChi-square testingPediatric sepsis mortalityIntravenous antibioticsCare bundleICU admissionCohort reviewSepsis mortalitySepsis recognitionPrimary outcomeCare unitFemale patientsHospital diagnosisLevel carePediatric sepsisAntibiotic delayBackground SepsisPediatric mortalityFighting the hidden pandemic of antimicrobial resistance in paediatrics: recommendations from the International Pediatric Association
Pana Z, El-Shabrawi M, Sultan M, Murray T, Alam A, Yewale V, Dharmapalan D, Klein J, Haddad J, Thacker N, Pulungan A, Hadjipanayis A. Fighting the hidden pandemic of antimicrobial resistance in paediatrics: recommendations from the International Pediatric Association. BMJ Paediatrics Open 2023, 7: e002084. PMID: 37500294, PMCID: PMC10387713, DOI: 10.1136/bmjpo-2023-002084.Peer-Reviewed Original ResearchCharacterizing healthcare worker attitudes toward the bivalent COVID-19 booster
Willebrand K, Fredrick J, Pischel L, Patel K, Roberts S, Murray T, Martinello R. Characterizing healthcare worker attitudes toward the bivalent COVID-19 booster. Antimicrobial Stewardship & Healthcare Epidemiology 2023, 3: s56-s57. PMCID: PMC10594485, DOI: 10.1017/ash.2023.300.Peer-Reviewed Original ResearchBooster doseBehavioral health unitHealthcare workersHealth unitsCOVID-19COVID-19 outbreakInpatient behavioral health unitFirst booster dosePrimary vaccination seriesCOVID-19 vaccinationCOVID-19 exposureBehavioral health settingsMonovalent vaccinationVaccination seriesBooster dosesBooster vaccineComplete responsePrevious vaccinationVaccine uptakeHealth HospitalGeneral populationSide effectsPsychiatric hospitalHealth settingsDemographic dataReducing MRSA Infection in a New NICU During the COVID-19 Pandemic.
Barrett R, Fleiss N, Hansen C, Campbell M, Rychalsky M, Murdzek C, Krechevsky K, Abbott M, Allegra T, Blazevich B, Dunphy L, Fox A, Gambardella T, Garcia L, Grimm N, Scoffone A, Bizzarro M, Murray T. Reducing MRSA Infection in a New NICU During the COVID-19 Pandemic. Pediatrics 2023, 151 PMID: 36625072, DOI: 10.1542/peds.2022-057033.Peer-Reviewed Original ResearchConceptsInvasive MRSA infectionsInfection prevention strategiesMethicillin-resistant Staphylococcus aureusMRSA infectionOutcome measuresPrevention strategiesCOVID-19 pandemicMultidisciplinary quality improvement initiativeLevel IV NICUSubsequent invasive infectionsMRSA colonization rateCoronavirus disease 2019 (COVID-19) pandemicHealthcare Improvement's ModelQuality improvement initiativesDisease 2019 pandemicEffectiveness of interventionsPersonal protective equipmentSupply chain shortagesHospitalized neonatesInvasive infectionsPatient daysSkin colonizationHand hygieneMost NICUsNICU
2022
Masking in early child care and COVID-19 infection
Murray T, Malik A, Gilliam W. Masking in early child care and COVID-19 infection. TheScienceBreaker 2022, 8 DOI: 10.25250/thescbr.brk665.Peer-Reviewed Original ResearchRecruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis
Öz H, Cheng E, Di Pietro C, Tebaldi T, Biancon G, Zeiss C, Zhang P, Huang P, Esquibies S, Britto C, Schupp J, Murray T, Halene S, Krause D, Egan M, Bruscia E. Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis. Cell Reports 2022, 41: 111797. PMID: 36516754, PMCID: PMC9833830, DOI: 10.1016/j.celrep.2022.111797.Peer-Reviewed Original ResearchConceptsC motif chemokine receptor 2Monocytes/macrophagesLung tissue damageCystic fibrosisTissue damageCF lungPulmonary neutrophilic inflammationPro-inflammatory environmentChemokine receptor 2CF lung diseaseNumber of monocytesSpecific therapeutic agentsGrowth factor βCF transmembrane conductance regulatorLung hyperinflammationLung neutrophiliaNeutrophilic inflammationNeutrophil inflammationInflammation contributesLung damageNeutrophil recruitmentLung diseaseLung tissueReceptor 2Therapeutic targetDisinfection of Virtual Reality Devices in Health Care Settings: In Vitro Assessment and Survey Study
Roberts S, Havill N, Flores RM, Hendrix C, Williams MJ, Feinn RS, Choi SJ, Martinello RA, Marks AM, Murray TS. Disinfection of Virtual Reality Devices in Health Care Settings: In Vitro Assessment and Survey Study. Journal Of Medical Internet Research 2022, 24: e42332. PMID: 36269222, PMCID: PMC9756115, DOI: 10.2196/42332.Peer-Reviewed Original ResearchPrevalence of Chronic Diseases, Depression, and Stress Among US Childcare Professionals During the COVID-19 Pandemic
Elharake JA, Shafiq M, Cobanoglu A, Malik AA, Klotz M, Humphries JE, Murray T, Patel KM, Wilkinson D, Yildirim I, Diaz R, Rojas R, Cohen A, Lee A, Omer SB, Gilliam WS. Prevalence of Chronic Diseases, Depression, and Stress Among US Childcare Professionals During the COVID-19 Pandemic. Preventing Chronic Disease 2022, 19: e61. PMID: 36137183, PMCID: PMC9541678, DOI: 10.5888/pcd19.220132.Peer-Reviewed Original ResearchConceptsPhysical health conditionsMental healthHealth conditionsChronic diseasesDepression ratesCOVID-19 pandemicSex/gender disparityPublic health officialsChildcare professionalsSevere asthmaHeart diseaseUS adultsAsthma ratesSociodemographic characteristicsHealth officialsDepressionDiseaseNational representativenessLinear regression modelsPrevalenceHealthRegression modelsPandemicProfessionalsGender disparitiesImplementation of Pre-Admission Caregiver Testing for COVID-19.
He M, Peaper DR, Murray T, Ciaburri R, Doyle J, Loyal J. Implementation of Pre-Admission Caregiver Testing for COVID-19. Hospital Pediatrics 2022, 12: e326-e329. PMID: 36047308, DOI: 10.1542/hpeds.2022-006715.Peer-Reviewed Original ResearchConceptsCOVID-19 testingPatient cohortingSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmissionBed capacityCohorting of patientsInpatient pediatric admissionsCoronavirus disease 2019 (COVID-19) transmissionTertiary children's hospitalPediatric emergency departmentCOVID-19 positivityCOVID-19Procedural admissionsIsolation precautionsAsymptomatic adultsNegative childrenOverall incidencePediatric admissionsChildren's HospitalEmergency departmentHospitalized childrenDirect admissionInfection preventionOverall bed capacityInpatient unitPositive test