2022
Telehealth Reduces Missed Appointments in Pediatric Patients with Tuberculosis Infection
Zhao A, Butala N, Luc CM, Feinn R, Murray TS. Telehealth Reduces Missed Appointments in Pediatric Patients with Tuberculosis Infection. Tropical Medicine And Infectious Disease 2022, 7: 26. PMID: 35202221, PMCID: PMC8877294, DOI: 10.3390/tropicalmed7020026.Peer-Reviewed Original ResearchTuberculosis infectionPediatric patientsAppointment ratesActive TB diseaseLatent tuberculosis infectionRetrospective chart reviewRisk of progressionPoor treatment adherenceChi-square testTB diseaseChart reviewTuberculosis clinicClinical variablesTreatment adherenceMissed appointmentsPatientsSecond cohortSecondary aimPrimary providersClinicTelehealthCOVID-19 pandemicTherapyHigh rateInfection
2019
The Ethics of Fecal Microbiota Transplant as a Tool for Antimicrobial Stewardship Programs
Murray TS, Herbst J. The Ethics of Fecal Microbiota Transplant as a Tool for Antimicrobial Stewardship Programs. The Journal Of Law, Medicine & Ethics 2019, 47: 541-554. PMID: 31957576, DOI: 10.1177/1073110519897730.Peer-Reviewed Original ResearchConceptsFecal microbiota transplantMultidrug-resistant organismsAntimicrobial stewardship programsMicrobiota transplantStewardship programsCurrent clinical indicationsPublic health threatPatient colonizationSevere recurrentAntibiotic useClinical indicationsResistant organismsAvailable antibioticsHealth threatTransplantAdditional evidenceTherapyInfectionRecurrent
2017
A Dual Case of Peritonitis and Central Nervous System Infection Caused by Nutritionally Variant Streptococcal Species
Vivar S, Girotto JE, Murray TS. A Dual Case of Peritonitis and Central Nervous System Infection Caused by Nutritionally Variant Streptococcal Species. Case Reports In Infectious Diseases 2017, 2017: 6012964. PMID: 28239499, PMCID: PMC5292362, DOI: 10.1155/2017/6012964.Peer-Reviewed Original ResearchNutritional variant streptococciCentral nervous system infectionCentral nervous system involvementEtiology of peritonitisVentriculoperitoneal shunt revisionNervous system infectionNervous system involvementCause of peritonitisEfficacy of treatmentClinical responseSystem infectionVP shuntShunt revisionSystem involvementInvasive infectionsPrevious neurosurgeryCNS penetrationVariant streptococciPeritonitisSusceptibility testingPotential roleSignificant pathogenStreptococcal speciesSecond agentInfection
2016
The Approach to Pseudomonas aeruginosa in Cystic Fibrosis
Talwalkar JS, Murray TS. The Approach to Pseudomonas aeruginosa in Cystic Fibrosis. Clinics In Chest Medicine 2016, 37: 69-81. PMID: 26857769, DOI: 10.1016/j.ccm.2015.10.004.BooksConceptsCystic fibrosisAcute pulmonary exacerbationsDuration of administrationSpecific patient characteristicsStandard of careSite of carePseudomonas aeruginosaPulmonary exacerbationsAntipseudomonal antibioticsPatient characteristicsTreatment optionsEpidemiologic linkChronic infectionHigh prevalenceTreatment decisionsNew vaccinesEarly identificationAggressive useFibrosisAntibiotic selectionInfectionCareLaboratory methodsAeruginosaExacerbation
2015
Baby bottle steam sterilizers for disinfecting home nebulizers inoculated with non-tuberculous mycobacteria
Towle D, Callan DA, Lamprea C, Murray TS. Baby bottle steam sterilizers for disinfecting home nebulizers inoculated with non-tuberculous mycobacteria. Journal Of Hospital Infection 2015, 92: 222-225. PMID: 26810616, DOI: 10.1016/j.jhin.2015.08.030.Peer-Reviewed Original ResearchThe contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children
Murray TS, Peaper DR. The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children. Current Opinion In Pediatrics 2015, 27: 124-131. PMID: 25565574, DOI: 10.1097/mop.0000000000000182.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBeta-Lactam ResistanceBeta-LactamasesChildChild, PreschoolCommunity-Acquired InfectionsCross InfectionDrug Resistance, MultipleEscherichia coliEscherichia coli InfectionsGram-Negative Bacterial InfectionsHumansInfantKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsPrevalenceConceptsMultidrug-resistant infectionsGram-negative rodsProlonged fecal carriageAntibiotic prescribing practicesPrevious antibiotic useExtended-spectrum β-lactamasesCommon risk factorsThird-generation cephalosporinsDiagnostic toolAppropriate therapyChallenging infectionsPrescribing practicesNeonatal ICULaboratory criteriaNew diagnostic toolsRisk factorsAntibiotic useFecal carriageCommunity transmissionClinical implicationsInfectionCephalosporin resistanceKlebsiella pneumoniaeReporting criteriaΒ-lactamases
2014
Extended-spectrum β-lactamase-producing Klebsiella pneumoniae in the neonatal intensive care unit: Does vancomycin play a role?
Somily AM, Alsubaie SS, BinSaeed AA, Torchyan AA, Alzamil FA, Al-Aska AI, Al-Khattaf FS, Khalifa LA, Al-Thawadi SI, Alaidan AA, Al-Ahdal MN, Al-Qahtani AA, Murray TS. Extended-spectrum β-lactamase-producing Klebsiella pneumoniae in the neonatal intensive care unit: Does vancomycin play a role? American Journal Of Infection Control 2014, 42: 277-282. PMID: 24581016, DOI: 10.1016/j.ajic.2013.09.028.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitESBL-producing Klebsiella pneumoniaeIntensive care unitIncidence density ratioRisk factorsCare unitΒ-lactamase-producing Klebsiella pneumoniaeExtended-spectrum β-lactamase-producing Klebsiella pneumoniaeKlebsiella pneumoniaeRetrospective cohort studySignificant risk factorsPossible risk factorsExtended-spectrum β-lactamaseCohort studyParenteral feedingMechanical ventilationTeaching hospitalNeonatesKlebsiella speciesUnivariate analyzesPossible predictorsInfectionVancomycinΒ-lactamasePneumoniae
2013
Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MS
Peaper DR, Kulkarni MV, Tichy AN, Jarvis M, Murray TS, Hodsdon ME. Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MS. Bioanalysis 2013, 5: 147-157. PMID: 23330558, PMCID: PMC5753620, DOI: 10.4155/bio.12.310.Peer-Reviewed Original ResearchConceptsLife-threatening infectionsIll patientsGram-negative rodsDiagnostic testsExpression of carbapenemasesAvailable diagnostic testsRapid diagnostic testsRatios of metabolitesLC-MS/MSCarbapenemase activityHodge testCarbapenem resistanceCarbapenemase productionCarbapenem antibioticsΒ-lactam antibioticsThreshold cutoffDA increaseErtapenem hydrolysisLC-MS/MS methodPatientsClinical laboratoriesAntibioticsLCMS/MSInfectionPhysiological levels
2012
Baby bottle steam sterilizers disinfect home nebulizers inoculated with bacterial respiratory pathogens
Towle D, Callan DA, Farrel PA, Egan ME, Murray TS. Baby bottle steam sterilizers disinfect home nebulizers inoculated with bacterial respiratory pathogens. Journal Of Cystic Fibrosis 2012, 12: 512-516. PMID: 23267773, DOI: 10.1016/j.jcf.2012.11.013.Peer-Reviewed Original ResearchConceptsHome nebulizersMethicillin-resistant Staphylococcus aureusBacterial respiratory pathogensResistant Staphylococcus aureusNon-mucoid Pseudomonas aeruginosaMucoid Pseudomonas aeruginosaRespiratory pathogensHaemophilus influenzaeBacterial infectionsClinical settingAdditional studiesBacterial growthStaphylococcus aureusStenotrophomonas maltophiliaPseudomonas aeruginosaViable bacteriaTreatmentNebulizerBurkholderia cepaciaInfectionInfluenzaeChronic versus Acute Pseudomonas aeruginosa Infection States
Kazmierczak B, Murray T. Chronic versus Acute Pseudomonas aeruginosa Infection States. 2012, 21-39. DOI: 10.1128/9781555818524.ch2.Peer-Reviewed Original ResearchVirulence factorsChronic Pseudomonas aeruginosa infectionFactor expressionPseudomonas aeruginosa infectionVirulence factor expressionP. aeruginosaAcute infectionChronic infectionAeruginosa infectionAnimal modelsMost bacterial pathogensAMP expressionInfectionInfection stateMucoid strainsBacterial pathogensHost-pathogen interactionsHost cellsExpressionEctopic expressionAeruginosaFactorsThe Ability of Virulence Factor Expression by Pseudomonas aeruginosa to Predict Clinical Disease in Hospitalized Patients
Ledizet M, Murray TS, Puttagunta S, Slade MD, Quagliarello VJ, Kazmierczak BI. The Ability of Virulence Factor Expression by Pseudomonas aeruginosa to Predict Clinical Disease in Hospitalized Patients. PLOS ONE 2012, 7: e49578. PMID: 23152923, PMCID: PMC3495863, DOI: 10.1371/journal.pone.0049578.Peer-Reviewed Original ResearchConceptsP. aeruginosa infectionAeruginosa infectionBacterial factorsHospitalized patientsUrinary tractPositive P. aeruginosa culturesP. aeruginosaUrinary tract cathetersP. aeruginosa isolatesLogistic regression modelsPseudomonas aeruginosaProspective cohortDiabetes mellitusSubgroup analysisClinical dataTreatment decisionsClinical diseaseAeruginosa isolatesAnimal modelsPatientsClinical sitesFactor expressionInfectionHost factorsP. aeruginosa culturesThe Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation
Murray TS, Okegbe C, Gao Y, Kazmierczak BI, Motterlini R, Dietrich LE, Bruscia EM. The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation. PLOS ONE 2012, 7: e35499. PMID: 22563385, PMCID: PMC3338523, DOI: 10.1371/journal.pone.0035499.Peer-Reviewed Original ResearchConceptsCORM-2 treatmentP. aeruginosa lung infectionP. aeruginosaAeruginosa lung infectionCORM-2Clinical P. aeruginosaMolecule CORM-2Current antimicrobial agentsChronic infectionLung infectionNew therapiesRelated infectionsNon-mucoid strainsReactive oxygen speciesInfectionNovel therapeutic propertiesTherapeutic propertiesAntimicrobial agentsAdditive effectPseudomonas aeruginosaBiofilm formationOxygen speciesTreatmentAeruginosa
2010
Lyme Disease
Murray TS, Shapiro ED. Lyme Disease. Clinics In Laboratory Medicine 2010, 30: 311-328. PMID: 20513553, PMCID: PMC3652387, DOI: 10.1016/j.cll.2010.01.003.Peer-Reviewed Original ResearchConceptsLyme diseaseClinical presentation variesOnly nonspecific symptomsCranial nerve palsyMultiple erythema migransSigns of infectionCommon vector-borne diseaseNerve palsyDisseminated diseaseMost patientsNonspecific symptomsErythema migransSerologic testingAppropriate antimicrobialsEarly diseasePresentation variesLate diseaseObjective signsSpirochete Borrelia burgdorferiDiseaseBorrelia burgdorferiPatientsMigransSymptomsInfection
2008
Acute Pyelonephritis Caused by Aerococcus urinae in a 12-Year-Old Boy
Murray TS, Muldrew KL, Finkelstein R, Hampton L, Edberg SC, Cappello M. Acute Pyelonephritis Caused by Aerococcus urinae in a 12-Year-Old Boy. The Pediatric Infectious Disease Journal 2008, 27: 760-762. PMID: 18574434, DOI: 10.1097/inf.0b013e318170af46.Peer-Reviewed Case Reports and Technical Notes
2007
Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients
Murray TS, Egan M, Kazmierczak BI. Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Current Opinion In Pediatrics 2007, 19: 83-88. PMID: 17224667, DOI: 10.1097/mop.0b013e3280123a5d.Peer-Reviewed Original ResearchConceptsCystic fibrosis patientsChronic colonizationAcute infectionFibrosis patientsCystic fibrosisP. aeruginosaChronic pulmonary colonizationChronic pulmonary diseaseCystic fibrosis airwayHost immune systemMucoid P. aeruginosaP. aeruginosa behaviorCystic fibrosis lungPulmonary diseaseClinical benefitChronic infectionP. aeruginosa pathogenesisLeading causePulmonary colonizationNew therapiesImmune systemAggressive usePotential therapeuticsInfectionPatients
2005
Epidemiology and Management of Infectious Diseases in International Adoptees
Murray TS, Groth ME, Weitzman C, Cappello M. Epidemiology and Management of Infectious Diseases in International Adoptees. Clinical Microbiology Reviews 2005, 18: 510-520. PMID: 16020687, PMCID: PMC1195971, DOI: 10.1128/cmr.18.3.510-520.2005.Peer-Reviewed Original Research