RIPLET, and not TRIM25, is required for endogenous RIG‐I‐dependent antiviral responses
Hayman T, Hsu A, Kolesnik T, Dagley L, Willemsen J, Tate M, Baker P, Kershaw N, Kedzierski L, Webb A, Wark P, Kedzierska K, Masters S, Belz G, Binder M, Hansbro P, Nicola N, Nicholson S. RIPLET, and not TRIM25, is required for endogenous RIG‐I‐dependent antiviral responses. Immunology And Cell Biology 2019, 97: 840-852. PMID: 31335993, DOI: 10.1111/imcb.12284.Peer-Reviewed Original ResearchConceptsRetinoic acid-inducible gene IRetinoic acid-inducible gene-I signalingPattern recognition receptorsInfluenza A virusRIG-I activationIII interferonsRecognition receptorsTripartite motif-containing 25Host antiviral defenseImmune signaling cascadesSusceptible to IAV infectionIFN responseInfluenza B virusIFN-stimulated genesHost cell pattern recognition receptorsHuman cell linesUpregulation of IFN-stimulated genesRIG-I.Gene IInnate immune systemRipletAntiviral defenseRIG-ITRIM25Production of type I