Premorbid Speech and Language Impairments in Childhood-Onset Schizophrenia: Association With Risk Factors
Nicolson R, Lenane M, Singaracharlu S, Malaspina D, Giedd JN, Hamburger SD, Gochman P, Bedwell J, Thaker GK, Fernandez T, Wudarsky M, Hommer DW, Rapoport JL. Premorbid Speech and Language Impairments in Childhood-Onset Schizophrenia: Association With Risk Factors. American Journal Of Psychiatry 2000, 157: 794-800. PMID: 10784474, DOI: 10.1176/appi.ajp.157.5.794.Peer-Reviewed Original ResearchConceptsChildhood-onset schizophreniaRisk factorsSchizophrenia spectrum disordersObstetrical complicationsMotor abnormalitiesDevelopmental impairmentMore obstetrical complicationsSmooth pursuit eye movementsChildhood-onset casesPathophysiology of schizophreniaEye-tracking dysfunctionLanguage-related brain regionsFamilial loading scoresFamilial risk factorsSocial impairmentNeurodevelopmental impairmentPremorbid abnormalitiesSpectrum disorderFamilial loadingPatientsLanguage impairmentBrain regionsSchizophreniaImpairmentAbnormalities