2023
The human milk component myo-inositol promotes neuronal connectivity
Paquette A, Carbone B, Vogel S, Israel E, Maria S, Patil N, Sah S, Chowdhury D, Kondratiuk I, Labhart B, Morrow A, Phillips S, Kuang C, Hondmann D, Pandey N, Biederer T. The human milk component myo-inositol promotes neuronal connectivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2221413120. PMID: 37433002, PMCID: PMC10374161, DOI: 10.1073/pnas.2221413120.Peer-Reviewed Original ResearchConceptsHuman milkNeuronal connectionsInfant brainBreast milk componentsExcitatory synapse densityCultured rat neuronsMature brain tissueHuman milk samplesAbility of neuronsHuman excitatory neuronsDose-dependent mannerExcitatory postsynaptic sitesSlice culture systemSynapse densityExcitatory neuronsDietary supplementationPostsynaptic sitesRat neuronsNeuronal connectivityOrganotypic slicesBrain tissuePostsynaptic specializationsOrganotypic slice culture systemBrain developmentBrain connectivity
2019
Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1
Ribic A, Crair MC, Biederer T. Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1. Cell Reports 2019, 26: 381-393.e6. PMID: 30625321, PMCID: PMC6345548, DOI: 10.1016/j.celrep.2018.12.069.Peer-Reviewed Original ResearchConceptsCortical plasticityCell adhesion molecule-1Critical periodJuvenile-like plasticityAdhesion molecule-1Primary visual cortexVisual critical periodThalamocortical inputsCortical maturationCircuit maturationV1 plasticityParvalbumin interneuronsFeedforward inhibitionSynaptic cell adhesion molecule 1Cell-autonomous mechanismsBrief lossCortical responsesSynaptic lociMolecule-1Visual cortexSynaptic factorsInterneuronsSpecific knockdownAdulthoodEyes
2016
Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1
Park KA, Ribic A, Gaupp F, Coman D, Huang Y, Dulla CG, Hyder F, Biederer T. Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1. Journal Of Neuroscience 2016, 36: 7464-7475. PMID: 27413156, PMCID: PMC4945666, DOI: 10.1523/jneurosci.0189-16.2016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA3 Region, HippocampalCell Adhesion Molecule-1Cell Adhesion MoleculesConditioning, ClassicalFearFemaleGABA AntagonistsGene Expression RegulationImmunoglobulinsIn Vitro TechniquesMaleMemory DisordersMiceMice, Inbred C57BLMice, KnockoutNeural InhibitionNeural PathwaysParvalbuminsPyridazinesSynapsesSynaptic PotentialsTime FactorsConceptsDiffusion tensor imagingHippocampal CA3 areaKO miceMagnetic resonance imagingExcitatory inputsFeedforward inhibitionSynCAM 1Pyramidal neuronsNetwork excitabilityCA3 areaMossy fibersExcitatory mossy fiber inputBrain regionsTensor imagingHippocampal CA3 circuitsParvalbumin-positive interneuronsCA3 pyramidal neuronsPV-positive interneuronsExcitatory synaptic driveKnock-out (KO) miceDevelopment of synapsesDifferent neuronal populationsMossy fiber inputsDistinct brain regionsSynaptic imbalance
2014
Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1
Ribic A, Liu X, Crair MC, Biederer T. Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1. The Journal Of Comparative Neurology 2014, 522: 900-920. PMID: 23982969, PMCID: PMC3947154, DOI: 10.1002/cne.23452.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAnalysis of VarianceAnimalsAnimals, NewbornCell Adhesion Molecule-1Cell Adhesion MoleculesCo-Repressor ProteinsDNA-Binding ProteinsElectroretinographyFemaleGene Expression Regulation, DevelopmentalImmunoglobulinsMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ImmunoelectronNerve Tissue ProteinsPhosphoproteinsReceptors, Metabotropic GlutamateRetinaRetinal Rod Photoreceptor CellsSynapsesVesicular Glutamate Transport Protein 1ConceptsCell adhesion molecule-1Adhesion molecule-1Ribbon synapsesKO retinasSynaptic cell adhesion molecule 1Molecule-1Mouse photoreceptor ribbon synapsesInner retinal layersPhotoreceptor ribbon synapsesRod visual pathwayEarly postnatal stagesPlexiform layerKO micePhotoreceptor synapsesSynaptic organizationExcitatory synapsesQuantitative ultrastructural analysisRetinal layersKnockout miceOuter nuclearVisual pathwaySynapse developmentElectroretinogram recordingsPostnatal stagesAdhesion molecules