2010
N-Glycosylation at the SynCAM (Synaptic Cell Adhesion Molecule) Immunoglobulin Interface Modulates Synaptic Adhesion*
Fogel AI, Li Y, Giza J, Wang Q, Lam TT, Modis Y, Biederer T. N-Glycosylation at the SynCAM (Synaptic Cell Adhesion Molecule) Immunoglobulin Interface Modulates Synaptic Adhesion*. Journal Of Biological Chemistry 2010, 285: 34864-34874. PMID: 20739279, PMCID: PMC2966101, DOI: 10.1074/jbc.m110.120865.Peer-Reviewed Original ResearchConceptsN-glycosylationTrans-synaptic interactionsN-glycansSite-specific N-glycansSynaptic cell adhesion molecule 1Site-specific N-glycosylationTrans-synaptic adhesionPost-translational modificationsSelect adhesion moleculesMutational studiesSynaptic adhesionGlycosylation sitesHeterophilic interactionsIg1 domainSynapse inductionPostsynaptic membraneAdhesion moleculesNeurobiological questionsSynaptic cleftStructural modelingPresynaptic terminalsDifferential mannerSialic acidCell adhesion molecule-1Adhesion
2006
SynCAM in Formation and Function of Synaptic Specializations
Biederer T. SynCAM in Formation and Function of Synaptic Specializations. 2006, 125-135. DOI: 10.1007/978-0-387-32562-0_9.Peer-Reviewed Original ResearchInteraction motifsSynCAM 1Short cytosolic tailProtein interaction motifsSingle transmembrane regionIg-like domainsCytosolic tailActin cytoskeletonTransmembrane regionIntracellular sequencesExtracellular sequencesAdaptor moleculeGeneral roleMembrane differentiationSynaptic differentiationCentral nervous systemPostsynaptic membraneAdhesion moleculesProteinSynaptic cleftMotifPresynaptic terminalsDifferentiationSequenceFamily members