Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength
Ramsey AM, Tang AH, LeGates TA, Gou XZ, Carbone BE, Thompson SM, Biederer T, Blanpied TA. Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength. Science Advances 2021, 7: eabf3126. PMID: 34417170, PMCID: PMC8378824, DOI: 10.1126/sciadv.abf3126.Peer-Reviewed Original ResearchAMPA receptorsSynaptic strengthAdhesion moleculesPostsynaptic receptor activationTranscellular interactionsGlutamate releasePresynaptic sitesGlutamate receptorsReceptor numberSubsynaptic distributionReceptor activationSynaptic functionAMPAR numberSignificant deficitsRecent evidenceReceptorsSynapsesRapid remodelingExtracellular domainLRRTM2