2011
Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria
Guo JK, Marlier A, Shi H, Shan A, Ardito TA, Du ZP, Kashgarian M, Krause DS, Biemesderfer D, Cantley LG. Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria. Journal Of The American Society Of Nephrology 2011, 23: 429-437. PMID: 22193389, PMCID: PMC3294312, DOI: 10.1681/asn.2011040396.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminuriaAnimalsAxl Receptor Tyrosine KinaseCell ProliferationDisease Models, AnimalFemaleHeparin-binding EGF-like Growth FactorIntegrasesIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsKidney GlomerulusKidney Tubules, ProximalMaleMembrane ProteinsMiceMice, TransgenicPodocytesProteinuriaProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesConceptsGlomerular proteinuriaTubular injuryTubular proliferationStructural glomerular injuryProteinuric renal diseaseOnset of albuminuriaRenal tubular atrophyDiphtheria toxin receptorRenal tubular cellsProximal tubule cellsGlomerular albuminuriaRenal failureSystemic inflammationTubular damageProgressive glomerulosclerosisRenal diseaseTubular atrophyGlomerular injuryRenal responsePodocyte lossProliferative responseTubular cellsAnimal modelsProteinuriaReceptor Axl
2010
Inhibition of Podocyte FAK Protects against Proteinuria and Foot Process Effacement
Ma H, Togawa A, Soda K, Zhang J, Lee S, Ma M, Yu Z, Ardito T, Czyzyk J, Diggs L, Joly D, Hatakeyama S, Kawahara E, Holzman L, Guan JL, Ishibe S. Inhibition of Podocyte FAK Protects against Proteinuria and Foot Process Effacement. Journal Of The American Society Of Nephrology 2010, 21: 1145-1156. PMID: 20522532, PMCID: PMC3152231, DOI: 10.1681/asn.2009090991.Peer-Reviewed Original ResearchTargeted deletion of βIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes
Stankewich MC, Gwynn B, Ardito T, Ji L, Kim J, Robledo RF, Lux SE, Peters LL, Morrow JS. Targeted deletion of βIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 6022-6027. PMID: 20231455, PMCID: PMC2851889, DOI: 10.1073/pnas.1001522107.Peer-Reviewed Original ResearchConceptsBetaIII spectrinSpinocerebellar ataxia type 5Spectrin membrane skeletonTargeted gene disruptionAmino acid transportersExcitatory amino acid transportersImpairs synaptogenesisProtein traffickingSeizure disorderGene disruptionDark Purkinje cellsMembrane skeletonAlphaII-spectrinAcid transportersMechanistic basisPurkinje cellsMembrane channelsGlutamate receptor deltaIntracellular pathwaysSpectrin bindsSynaptic proteinsSpectrinReceptor deltaProteinGolgi profiles
2006
Prevention of mesangial sclerosis by bone marrow transplantation
Guo J, Ardito TA, Kashgarian M, Krause DS. Prevention of mesangial sclerosis by bone marrow transplantation. Kidney International 2006, 70: 910-913. PMID: 16850025, DOI: 10.1038/sj.ki.5001698.Peer-Reviewed Original ResearchConceptsBone marrow transplantationMesangial sclerosisMarrow transplantationUrinary albumin lossSimilar therapeutic effectsOnset of diseaseWild-type BMIntrarenal administrationRenal functionRenal histologyRenal diseaseDisease onsetRenal pathologyBM cellsTherapeutic effectEngraftment levelsRenal cellsAlbumin lossKidney samplesMiceSclerosisTransplantationUntreated controlsDiseaseAdministration
1995
Germinal matrix microvascular maturation correlates inversely with the risk period for neonatal intraventricular hemorrhage
Ment L, Stewart W, Ardito T, Madri J. Germinal matrix microvascular maturation correlates inversely with the risk period for neonatal intraventricular hemorrhage. Brain Research 1995, 84: 142-149. PMID: 7720213, DOI: 10.1016/0165-3806(94)00168-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneCerebral HemorrhageDisease Models, AnimalFemaleHumansInfant, NewbornMicrocirculationMicroscopy, ElectronRisk FactorsConceptsNeonatal intraventricular hemorrhageIntraventricular hemorrhagePostnatal dayRisk periodDay 1Blood-brain barrierNewborn beagle pupsTenth postnatal dayEndothelial cell areaBasal lamina depositionPerinatal inductionPreterm neonatesBasement membrane areaWeeks' gestationGestational agePostnatal ageGerminal matrixBeagle pupsElectron microscopic examinationLuminal areaTight junction lengthWhite matterDay 10Time pointsBeagle model
1991
Beagle pup germinal matrix maturation studies.
Ment L, Stewart W, Ardito T, Madri J. Beagle pup germinal matrix maturation studies. Stroke 1991, 22: 390-395. PMID: 2003309, DOI: 10.1161/01.str.22.3.390.Peer-Reviewed Original ResearchConceptsAlpha-smooth muscle actinIntraventricular hemorrhageDay 1Muscle actinRisk periodGlial fibrillary acidic proteinGerminal matrix vasculatureNewborn beagle pupsPostnatal day 1Postnatal day 4Postnatal day 10Fibrillary acidic proteinGerminal matrix vesselsGerminal matrix tissuePreterm infantsImmunohistochemical studyPerinatal maturationPostnatal dayBeagle pupsVessel densityHemorrhageExtracellular matrix componentsDay 4Day 10Basement membrane proteins