2020
Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis
Zhan W, Akshintala V, Greer PJ, Greer JB, Alkaade S, Anderson MA, Muniraj T, Papachristou GI, Sandhu BS, Slivka A, Wilcox CM, Bellin MD, Singh VK, Yadav D, Brand RE, Whitcomb DC, Group F. Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis. Pancreatology 2020, 20: 1368-1378. PMID: 32967795, DOI: 10.1016/j.pan.2020.08.025.Peer-Reviewed Original ResearchConceptsSerum trypsinogen levelsChronic pancreatitisTrypsinogen levelsAcinar cell functionCP patientsParenchymal lossCell functionComplex inflammatory disorderExocrine pancreatic insufficiencyCT-based criteriaNAPS2 studySerum trypsinogenAcinar cell lossSurgical resectionFinal cohortInflammatory cellsInflammatory disordersControl subjectsSeverity scoreClinical managementPancreatic insufficiencyStellate cellsNormal rangeCell lossIslet cellsConstant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort
Dunbar E, Greer PJ, Melhem N, Alkaade S, Amann ST, Brand R, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda NM, LaRusch J, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Wilcox CM, Singh VK, Yadav D, Whitcomb DC. Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort. Journal Of Gastroenterology 2020, 55: 1000-1009. PMID: 32681239, PMCID: PMC9124361, DOI: 10.1007/s00535-020-01703-w.Peer-Reviewed Original ResearchConceptsConstant severe painRecurrent acute pancreatitisChronic pancreatitisDepression-associated genesCP patientsPain severityAntidepressant usePancreatitis patientsPain experienceProspective randomized trialsAntidepressant medication usePattern of painCase report formsChronic opioidsIslet autotransplantationAntidepressant therapyTotal pancreatectomyMedication usePain managementRandomized trialsCounseling patientsRetrospective studyAcute pancreatitisClinical trialsMajor depressionAGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis
Feuerstein J, Isaacs K, Schneider Y, Siddique S, Falck-Ytter Y, Singh S, Chachu K, Day L, Lebwohl B, Muniraj T, Patel A, Peery A, Shah R, Sultan S, Singh H, Singh S, Spechler S, Su G, Thrift A, Weiss J, Weizman A, Feuerstein J, Singh S, Isaacs K, Schneider Y, Falck-Ytter Y, Siddique S, Allegretti J, Terdiman J, Singh S, Siddique S. AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis. Gastroenterology 2020, 158: 1450-1461. PMID: 31945371, PMCID: PMC7175923, DOI: 10.1053/j.gastro.2020.01.006.Peer-Reviewed Original ResearchAdultBiological ProductsClinical Decision-MakingClinical Trials as TopicColectomyColitis, UlcerativeColonColonoscopyDrug Therapy, CombinationEvidence-Based MedicineGastroenterologyGlucocorticoidsHumansImmunologic FactorsIntestinal MucosaSeverity of Illness IndexSocieties, MedicalTreatment OutcomeUnited States
2018
AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis
Ko C, Singh S, Feuerstein J, Falck-Ytter C, Falck-Ytter Y, Cross R, Committee A, Crockett S, Falck-Ytter Y, Feuerstein J, Flamm S, Inadomi J, Ko C, Muniraj T, O’Shea R, Pandolfino J, Patel A, Sharaf R, Siddique S, Su G, Wang K, Weizman A. AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis. Gastroenterology 2018, 156: 748-764. PMID: 30576644, PMCID: PMC6858922, DOI: 10.1053/j.gastro.2018.12.009.Peer-Reviewed Original Research
2014
Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features
Muniraj T, Aslanian HR, Farrell J, Jamidar PA. Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features. Disease-a-Month 2014, 60: 530-550. PMID: 25510320, DOI: 10.1016/j.disamonth.2014.11.002.Peer-Reviewed Original Research
2012
Acute Pancreatitis
Muniraj T, Gajendran M, Thiruvengadam S, Raghuram K, Rao S, Devaraj P. Acute Pancreatitis. Disease-a-Month 2012, 58: 98-144. PMID: 22370054, DOI: 10.1016/j.disamonth.2012.01.005.Peer-Reviewed Original Research