Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis
Zhan W, Akshintala V, Greer PJ, Greer JB, Alkaade S, Anderson MA, Muniraj T, Papachristou GI, Sandhu BS, Slivka A, Wilcox CM, Bellin MD, Singh VK, Yadav D, Brand RE, Whitcomb DC, Group F. Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis. Pancreatology 2020, 20: 1368-1378. PMID: 32967795, DOI: 10.1016/j.pan.2020.08.025.Peer-Reviewed Original ResearchConceptsSerum trypsinogen levelsChronic pancreatitisTrypsinogen levelsAcinar cell functionCP patientsParenchymal lossCell functionComplex inflammatory disorderExocrine pancreatic insufficiencyCT-based criteriaNAPS2 studySerum trypsinogenAcinar cell lossSurgical resectionFinal cohortInflammatory cellsInflammatory disordersControl subjectsSeverity scoreClinical managementPancreatic insufficiencyStellate cellsNormal rangeCell lossIslet cellsEndoscopic ultrasound‐guided fine needle aspiration of accessory spleen: Cytomorphologic features and diagnostic considerations
Gilani SM, Muniraj T, Farrell JJ, Aslanian HR, Cai G. Endoscopic ultrasound‐guided fine needle aspiration of accessory spleen: Cytomorphologic features and diagnostic considerations. Diagnostic Cytopathology 2020, 48: 623-628. PMID: 32315514, DOI: 10.1002/dc.24434.Peer-Reviewed Original ResearchConceptsEndoscopic ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationFine-needle aspirationProminent vascularityLymphoid cellsLarge platelet aggregatesCytomorphologic featuresNeedle aspirationNeoplastic processNon-specific clinical symptomsKey cytomorphologic featuresMass-forming lesionsPancreatic tail regionMixed inflammatory cellsKey cytologic featuresSmall-sized lymphocytesPancreas/Most patientsMale patientsSurgical managementClinical symptomsInflammatory cellsMean agePeripancreatic tissueDiagnostic challenge