2020
Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort
Lewis MD, Talluri J, Wilcox CM, Abberbock JN, Tang G, Conwell DL, Banks PA, Cote GA, Sherman S, Alkaade S, Gardner TB, Anderson MA, Sandhu BS, Muniraj T, Forsmark CE, Guda N, Gelrud A, Romagnuolo J, Brand R, LaRusch J, Amann ST, Slivka A, Whitcomb DC, Yadav D. Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort. Clinical Gastroenterology And Hepatology 2020, 19: 349-357. PMID: 32240833, PMCID: PMC7529676, DOI: 10.1016/j.cgh.2020.03.047.Peer-Reviewed Original ResearchConceptsOnset of symptomsModerate alcohol drinkersNorth American cohortAlcohol drinkersAge of onsetAmerican cohortAlcohol useChronic pancreatitisClinical featuresLate-onset idiopathic chronic pancreatitisNorth American Pancreatitis Study 2Genetic variantsEarly-onset ICPLate-onset ICPQuarter of patientsHalf of patientsIdiopathic chronic pancreatitisHigher proportionHeavy alcohol useCross-sectional analysisICP symptomsConstant painMedian ageAvailable patientsProspective study
2018
Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry
Phillips AE, LaRusch J, Greer P, Abberbock J, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Brand RE, Conwell D, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda N, Lewis M, Money ME, Muniraj T, Sandhu BS, Sherman S, Singh VK, Slivka A, Tang G, Wilcox CM, Whitcomb DC, Yadav D. Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry. Pancreatology 2018, 18: 528-535. PMID: 29859674, PMCID: PMC8715541, DOI: 10.1016/j.pan.2018.05.482.Peer-Reviewed Original ResearchPathogenic genetic variantsRecurrent acute pancreatitisAA patientsAA subjectsGenetic variantsAfrican ancestryGenetic susceptibility factorsComplex risk factorsAfrican American subjectsNAPS2 studyAlcohol etiologyAcute pancreatitisChronic pancreatitisEA patientsCP subjectsRisk factorsAA casesPatientsPancreatitisSusceptibility factorsPrevalenceFurther studiesEA subjectsStructured questionnaireSPINK1
2012
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, Alkaade S, Amann S, Anderson M, Baillie J, Banks P, Conwell D, Coté G, Cotton P, DiSario J, Farrer L, Forsmark C, Johnstone M, Gardner T, Gelrud A, Greenhalf W, Haines J, Hartman D, Hawes R, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem N, Money M, Muniraj T, Papachristou G, Pericak-Vance M, Romagnuolo J, Schellenberg G, Sherman S, Simon P, Singh V, Slivka A, Stolz D, Sutton R, Weiss F, Wilcox C, Zarnescu N, Wisniewski S, O'Connell M, Kienholz M, Roeder K, Barmada M, Yadav D, Devlin B. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nature Genetics 2012, 44: 1349-1354. PMID: 23143602, PMCID: PMC3510344, DOI: 10.1038/ng.2466.Peer-Reviewed Original Research