2000
Pulse pressure and risk for myocardial infarction and heart failure in the elderly
Vaccarino V, Holford T, Krumholz H. Pulse pressure and risk for myocardial infarction and heart failure in the elderly. Journal Of The American College Of Cardiology 2000, 36: 130-138. PMID: 10898424, DOI: 10.1016/s0735-1097(00)00687-2.Peer-Reviewed Original ResearchConceptsCongestive heart failureCoronary heart diseaseSystolic blood pressureCardiovascular end pointsDiastolic blood pressurePulse pressureBlood pressureEnd pointHeart failureIndependent predictorsOverall mortalityIncidence of CHFIncidence of CHDEffect of PPElevated systolic blood pressureCurrent hypertension guidelinesIncident CHF eventsCHD risk factorsCurrent medication useIncident CHD eventsPowerful independent predictorBlood pressure parametersBlood pressure variablesElevated pulse pressureDiastolic hypertension
1997
Are cancers of the salivary gland increasing? Experience from Connecticut, USA.
Zheng T, Holford T, Chen Y, Ward B, Liu W, Flannery J, Boyle P. Are cancers of the salivary gland increasing? Experience from Connecticut, USA. International Journal Of Epidemiology 1997, 26: 264-271. PMID: 9169160, DOI: 10.1093/ije/26.2.264.Peer-Reviewed Original ResearchConceptsSalivary glandsRelative riskBirth cohortRare squamous cell carcinomaEpstein-Barr virus infectionConnecticut Tumor Registry dataTime trendsComparable relative riskSquamous cell carcinomaTumor registry dataAge group 40Salivary gland cancerYears of ageOlder age groupsRecent birth cohortsObserved time trendsPrior cancerLower gumCell carcinomaGland cancerIncidence rateRisk factorsUnivariate analysisCancer sitesRegistry data
1995
Importance of events per independent variable in proportional hazards regression analysis II. Accuracy and precision of regression estimates
Peduzzi P, Concato J, Feinstein A, Holford T. Importance of events per independent variable in proportional hazards regression analysis II. Accuracy and precision of regression estimates. Journal Of Clinical Epidemiology 1995, 48: 1503-1510. PMID: 8543964, DOI: 10.1016/0895-4356(95)00048-8.Peer-Reviewed Original ResearchImportance of events per independent variable in proportional hazards analysis I. Background, goals, and general strategy
Concato J, Peduzzi P, Holford T, Feinstein A. Importance of events per independent variable in proportional hazards analysis I. Background, goals, and general strategy. Journal Of Clinical Epidemiology 1995, 48: 1495-1501. PMID: 8543963, DOI: 10.1016/0895-4356(95)00510-2.Peer-Reviewed Original Research
1993
Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery
Peduzzi P, Wittes J, Detre K, Holford T. Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery. Statistics In Medicine 1993, 12: 1185-1195. PMID: 8210821, DOI: 10.1002/sim.4780121302.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryArtery bypass surgeryTreatment groupsAlternative treatment groupBypass surgeryTreatment changesVeterans Administration Cooperative StudyTime of randomizationRandomized clinical trialsTreat analysisClinical trialsOutcome eventsRandom treatment assignmentCooperative StudyVeterans AffairsTreatment assignmentTherapySurgeryTrialsGroupPatients
1992
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function
1991
Intent-to-treat analysis and the problem of crossovers An example from the Veterans Administration coronary bypass surgery study
Peduzzi P, Detre K, Wittes J, Holford T. Intent-to-treat analysis and the problem of crossovers An example from the Veterans Administration coronary bypass surgery study. Journal Of Thoracic And Cardiovascular Surgery 1991, 101: 481-487. PMID: 1999942, DOI: 10.1016/s0022-5223(19)36731-5.Peer-Reviewed Original ResearchConceptsTreat analysisTreatment changesVeterans Administration Cooperative StudyDate of randomizationIschemic heart diseaseRandomized clinical trialsNew treatment groupEffect of treatmentStable anginaSurgical therapyMedical therapySurgical treatmentInitial treatmentSurgical interventionSurgery StudyMajor trialsHeart diseaseClinical trialsTreatment groupsCooperative StudySurvival dataTreatmentTherapyTrialsAdherence