2000
Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury
Bracken M, Aldrich E, Herr D, Hitchon P, Holford T, Marshall L, Nockels R, Pascale V, Shepard M, Sonntag V, Winn H, Young W. Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury. Journal Of Trauma And Acute Care Surgery 2000, 48: 558-561. PMID: 10744306, DOI: 10.1097/00005373-200003000-00036.Commentaries, Editorials and LettersConceptsNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudyAcute spinal cord injurySpinal Cord Injury StudyClinical measurementsHigh-dose methylprednisoloneSecondary neuronal damageSpinal cord injuryRisk benefitNeuronal damageFunctional recoverySafety profileCord injuryPharmacologic agentsSpinal injuryInjury studiesInnovative therapiesTrialsStatistical analysisInjuryMulticenterMethylprednisoloneSeries of trialsTherapyPrevention
1993
Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery
Peduzzi P, Wittes J, Detre K, Holford T. Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery. Statistics In Medicine 1993, 12: 1185-1195. PMID: 8210821, DOI: 10.1002/sim.4780121302.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryArtery bypass surgeryTreatment groupsAlternative treatment groupBypass surgeryTreatment changesVeterans Administration Cooperative StudyTime of randomizationRandomized clinical trialsTreat analysisClinical trialsOutcome eventsRandom treatment assignmentCooperative StudyVeterans AffairsTreatment assignmentTherapySurgeryTrialsGroupPatients
1991
Intent-to-treat analysis and the problem of crossovers An example from the Veterans Administration coronary bypass surgery study
Peduzzi P, Detre K, Wittes J, Holford T. Intent-to-treat analysis and the problem of crossovers An example from the Veterans Administration coronary bypass surgery study. Journal Of Thoracic And Cardiovascular Surgery 1991, 101: 481-487. PMID: 1999942, DOI: 10.1016/s0022-5223(19)36731-5.Peer-Reviewed Original ResearchConceptsTreat analysisTreatment changesVeterans Administration Cooperative StudyDate of randomizationIschemic heart diseaseRandomized clinical trialsNew treatment groupEffect of treatmentStable anginaSurgical therapyMedical therapySurgical treatmentInitial treatmentSurgical interventionSurgery StudyMajor trialsHeart diseaseClinical trialsTreatment groupsCooperative StudySurvival dataTreatmentTherapyTrialsAdherence
1988
Persistent Pulmonary Hypertension
Reece E, Moya F, Yazigi R, Holford T, Duncan C, Ehrenkranz R. Persistent Pulmonary Hypertension. Obstetric Anesthesia Digest 1988, 8: 58. DOI: 10.1097/00132582-198807000-00009.Peer-Reviewed Original Research
1985
ESTROGEN REPLACEMENT THERAPY AND FIBROCYSTIC BREAST DISEASE IN POSTMENOPAUSAL WOMEN1
BERKOWITZ G, KELSEY J, HOLFORD T, LIVOLSI V, MERINO M, BECK G, ORT S, O'CONNOR T, WHITE C. ESTROGEN REPLACEMENT THERAPY AND FIBROCYSTIC BREAST DISEASE IN POSTMENOPAUSAL WOMEN1. American Journal Of Epidemiology 1985, 121: 238-245. PMID: 4014118, DOI: 10.1093/oxfordjournals.aje.a113994.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseEstrogen replacement therapyBreast diseaseReplacement therapyPostmenopausal womenHospital-based case-control studyMedical care utilizationPossible risk factorsCase-control studyDuration of useOdds of diseasePostmenopausal women1Care utilizationMenopausal estrogensExcess oddsRisk factorsSurgical conditionsTherapyDiseasePositive associationMore yearsWomenOddsAssociationEstrogen
1982
A CASE-CONTROL STUDY OF CANCER OF THE ENDOMETRIUM
KELSEY J, LIVOLSI V, HOLFORD T, FISCHER D, MOSTOW E, SCHWARTZ P, O'CONNOR T, WHITE C. A CASE-CONTROL STUDY OF CANCER OF THE ENDOMETRIUM. American Journal Of Epidemiology 1982, 116: 333-342. PMID: 7114042, DOI: 10.1093/oxfordjournals.aje.a113417.Peer-Reviewed Original ResearchConceptsCase-control studyEndometrial cancerHospital-based case-control studyEstrogen replacement therapyOral contraceptivesDecreased riskReplacement therapyElevated riskOlder ageCancerStatistical significanceWomenRiskNulliparityOverweightMenopauseEndometriumPregnancyContraceptivesTherapyEpidemiologyAN EPIDEMIOLOGIC STUDY OF HIP FRACTURE IN POSTMENOPAUSAL WOMEN
KREIGER N, KELSEY J, HOLFORD T, O'CONNOR T. AN EPIDEMIOLOGIC STUDY OF HIP FRACTURE IN POSTMENOPAUSAL WOMEN. American Journal Of Epidemiology 1982, 116: 141-148. PMID: 7102649, DOI: 10.1093/oxfordjournals.aje.a113388.Peer-Reviewed Original Research