2007
Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients
Ruaño G, Goethe J, Caley C, Woolley S, Holford T, Kocherla M, Windemuth A, Leon J. Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients. Molecular Psychiatry 2007, 12: 474-482. PMID: 17199131, DOI: 10.1038/sj.mp.4001944.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnalysis of VarianceAntipsychotic AgentsApolipoproteinsAppetite RegulationAryldialkylphosphataseBenzodiazepinesCross-Sectional StudiesFemaleGenomicsHumansLipid MetabolismMaleMental DisordersMiddle AgedOlanzapinePolymorphism, Single NucleotideReceptors, Cell SurfaceReceptors, LeptinReceptors, Neuropeptide YRisperidoneScavenger Receptors, Class BWeight GainConceptsSingle nucleotide polymorphismsPhysiogenomic analysisNeuropeptide Y receptor Y5Receptor single nucleotide polymorphismsScavenger receptor class BRisperidone-treated patientsSide effect profileReceptor class BDrug-specific mechanismsSimilar side effectsGenetic associationAtypical antipsychoticsEffect profileAppetite peptidesApolipoprotein ELeptin receptorParaoxonase 1Side effectsPatientsOlanzapineRisperidoneElevated weightApolipoprotein A4Lipid homeostasisMember 1
2000
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk
Holford T, Zheng T, Mayne S, Zahm S, Tessari J, Boyle P. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. International Journal Of Epidemiology 2000, 29: 975-982. PMID: 11101537, DOI: 10.1093/ije/29.6.975.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskProtective effectBreast adipose tissue samplesYale-New Haven HospitalBreast-related surgeryAdipose tissue samplesStandardized questionnaireHealth concernCYP2B inducersAdverse effectsLogistic ridge regressionTissue samplesExposure levelsSignificant differencesMajor environmental health concernRiskEnvironmental health concernsPCB congenersDioxin-like congenersJoint effectsPatientsStatistical analysisSurgeryRegressionA Randomized Controlled Trial of Auricular Acupuncture for Cocaine Dependence
Avants S, Margolin A, Holford T, Kosten T. A Randomized Controlled Trial of Auricular Acupuncture for Cocaine Dependence. JAMA Internal Medicine 2000, 160: 2305-2312. PMID: 10927727, DOI: 10.1001/archinte.160.15.2305.Peer-Reviewed Original ResearchConceptsAuricular acupunctureCocaine dependenceCocaine addictionOpiate dependent populationUrine toxicology screenMethadone-maintained patientsCocaine-negative urine samplesDrug treatment facilitiesPrimary outcomeControlled TrialsToxicology screenTreatment modalitiesTreat sampleEffective treatmentUrine dataAcupunctureTreatment sessionsCocaine useRelaxation controlUrine samplesPatientsLongitudinal analysisTreatmentFurther investigationControl condition
1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-CareMethylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Neurosurgical FOCUS 1998, 5: e1. DOI: 10.3171/foc.1998.5.3.1.Peer-Reviewed Original ResearchAcute spinal cord injuryHours of injurySpinal cord injuryFunctional recoveryCord injuryMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMethods PatientsMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-Care
1995
Second solid malignancies after combined modality therapy for Hodgkin's disease.
Doria R, Holford T, Farber L, Prosnitz L, Cooper D. Second solid malignancies after combined modality therapy for Hodgkin's disease. Journal Of Clinical Oncology 1995, 13: 2016-22. PMID: 7636543, DOI: 10.1200/jco.1995.13.8.2016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyFemaleFollow-Up StudiesHodgkin DiseaseHumansIncidenceLymphoma, Non-HodgkinMaleMiddle AgedNeoplasms, Second PrimaryPoisson DistributionRadiation InjuriesRadiotherapyRadiotherapy DosageRecurrenceRemission InductionRisk FactorsConceptsSecond solid malignanciesActuarial incidenceRelative riskHodgkin's diseaseSolid tumorsGroup BRecurrent diseaseSolid malignanciesGroup AUntreated advanced Hodgkin's diseaseAdvanced Hodgkin's diseaseOverall relative riskLow-dose radiationSignificant increaseAdvanced diseaseUntreated patientsModality therapyHodgkin's lymphomaPatientsDiseaseCarcinogenic effectsChemotherapyLymphomaMalignancyCMT
1993
Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery
Peduzzi P, Wittes J, Detre K, Holford T. Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery. Statistics In Medicine 1993, 12: 1185-1195. PMID: 8210821, DOI: 10.1002/sim.4780121302.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryArtery bypass surgeryTreatment groupsAlternative treatment groupBypass surgeryTreatment changesVeterans Administration Cooperative StudyTime of randomizationRandomized clinical trialsTreat analysisClinical trialsOutcome eventsRandom treatment assignmentCooperative StudyVeterans AffairsTreatment assignmentTherapySurgeryTrialsGroupPatients
1992
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function
1991
A prospective longitudinal study of growth in twin gestations compared with growth in singleton pregnancies. II. The fetal limbs.
Reece E, Yarkoni S, Abdalla M, Gabrielli S, Holford T, O'Connor T, Bargar M, Hobbins J. A prospective longitudinal study of growth in twin gestations compared with growth in singleton pregnancies. II. The fetal limbs. Journal Of Ultrasound In Medicine 1991, 10: 445-450. PMID: 1942233, DOI: 10.7863/jum.1991.10.8.445.Peer-Reviewed Original ResearchConceptsTwin gestationsProspective longitudinal studyFetal growthMultiple biometric parametersLongitudinal studySingleton pregnanciesProspective studyTwin APregnancy managementSeparate nomogramsClinical importanceGestationFetal anatomyFemur lengthFetal limbsLong bonesHumerus lengthUlna lengthTibia lengthWeeksBiometric parametersGrowth velocityEvaluation of growthSingletonsPatients
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose
1987
Screening for gestational diabetes: One-hour carbohydrate tolerance test performed by a virtually tasteless polymer of glucose
Reece E, Holford T, Tuck S, Bargar M, O'Connor T, Hobbins J. Screening for gestational diabetes: One-hour carbohydrate tolerance test performed by a virtually tasteless polymer of glucose. American Journal Of Obstetrics And Gynecology 1987, 156: 132-134. PMID: 3799747, DOI: 10.1016/0002-9378(87)90223-7.Peer-Reviewed Original ResearchComparison of the logistic and Cox regression models when outcome is determined in all patients after a fixed period of time
Peduzzi P, Holford T, Detre K, Chan Y. Comparison of the logistic and Cox regression models when outcome is determined in all patients after a fixed period of time. Journal Of Clinical Epidemiology 1987, 40: 761-767. PMID: 3597677, DOI: 10.1016/0021-9681(87)90127-5.Peer-Reviewed Original Research
1986
Intrapartum fetal weight estimation: a comparison of three formulae.
Yarkoni S, Reece E, Wan M, Holford T, Romero R, Hobbins J. Intrapartum fetal weight estimation: a comparison of three formulae. Journal Of Ultrasound In Medicine 1986, 5: 707-710. PMID: 3543391, DOI: 10.7863/jum.1986.5.12.707.Peer-Reviewed Original Research