1997
The increase of Hodgkin's disease incidence among young adults
Chen Y, Zheng T, Chou M, Boyle P, Holford T. The increase of Hodgkin's disease incidence among young adults. Cancer 1997, 79: 2209-2218. PMID: 9179069, DOI: 10.1002/(sici)1097-0142(19970601)79:11<2209::aid-cncr20>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsHodgkin's disease incidenceHodgkin's diseaseRisk factorsVirus infectionYoung adultsEpstein-Barr virus infectionHuman immunodeficiency virus (HIV) infectionConnecticut Tumor RegistryImmunodeficiency virus infectionAnalytical epidemiologic studiesMajor risk factorIncidence rate changesAdults ages 20Young adults ages 20Tumor RegistryHistologic typeDisease incidenceCohort analysisEpidemiologic studiesAge 20Cohort patternsCohort phenomenonIncidenceDiseaseYoung femalesTime trend of female breast carcinoma In Situ by race and histology in Connecticut, U.S.A.
Zheng T, Holford T, Chen Y, Jones B, Flannery J, Boyle P. Time trend of female breast carcinoma In Situ by race and histology in Connecticut, U.S.A. European Journal Of Cancer 1997, 33: 96-100. PMID: 9071907, DOI: 10.1016/s0959-8049(96)00371-1.Peer-Reviewed Original ResearchConceptsAge-adjusted incidence ratesSitu breast cancerFemale breast carcinomaIncidence rateBreast cancerMammography screeningBreast carcinomaOverall age-adjusted incidence rateAge group 40 yearsAge groupsEarly-stage breast cancerAge-specific incidence ratesFemale breast cancer incidenceConnecticut Tumor RegistryBreast cancer incidenceStage breast cancerEfficacy of mammographyFemale breast cancerAge group 40Older age groupsTime trendsTumor RegistryIncident casesDuctal carcinomaCancer incidence
1996
Second solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation.
Salloum E, Doria R, Schubert W, Zelterman D, Holford T, Roberts K, Farber L, Kiehl R, Cardinale J, Cooper D. Second solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation. Journal Of Clinical Oncology 1996, 14: 2435-43. PMID: 8823321, DOI: 10.1200/jco.1996.14.9.2435.Peer-Reviewed Original ResearchConceptsOverall relative riskHodgkin's diseaseRT groupRelative riskSolid tumorsCMT groupRadiation therapyLung cancerBreast cancerEarly-stage Hodgkin's diseaseFull-dose radiation therapyInvolved-field radiationSecond solid tumorsConnecticut Tumor RegistryEarly-stage diseaseLong-term survivorsDifferent therapeutic approachesCases of lungLow-dose radiationSignificant increaseActuarial incidenceMedian followSalvage chemotherapyAdvanced diseaseDurable remissions
1995
Time trend in pancreatic cancer incidence in connecticut, 1935–1990
Zheng T, Holford T, Ward B, McKay L, Flannery J, Boyle P. Time trend in pancreatic cancer incidence in connecticut, 1935–1990. International Journal Of Cancer 1995, 61: 622-627. PMID: 7768634, DOI: 10.1002/ijc.2910610507.Peer-Reviewed Original ResearchConceptsOverall age-adjusted incidence rateAge-adjusted incidence ratesIncidence rateRecent birth cohortsPancreatic cancerBirth cohortIncident pancreatic cancer casesPancreatic cancer incidence ratesAge groupsAge-specific incidence ratesPancreatic cancer incidenceConnecticut Tumor RegistryBirth cohort trendsPancreatic cancer casesCancer incidence ratesTumor RegistryCancer incidenceCancer casesCohort modelingCohort trendsTime trendsCohortCancerIncidenceSex
1994
Time trend and the age‐period‐cohort effect on the incidence of histologic types of lung cancer in connecticut, 1960‐1989
Zheng T, Holford T, Boyle P, Chen Y, Ward B, Flannery J, Mayne S. Time trend and the age‐period‐cohort effect on the incidence of histologic types of lung cancer in connecticut, 1960‐1989. Cancer 1994, 74: 1556-1567. PMID: 8062189, DOI: 10.1002/1097-0142(19940901)74:5<1556::aid-cncr2820740511>3.0.co;2-0.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma, Bronchiolo-AlveolarAdultAge FactorsAgedAged, 80 and overCarcinomaCarcinoma, Small CellCarcinoma, Squamous CellCohort EffectCohort StudiesConnecticutFemaleHumansIncidenceLung NeoplasmsMaleMiddle AgedModels, StatisticalRegistriesSex FactorsSmokingTime FactorsConceptsAge-adjusted incidence ratesMajor histologic typesOverall age-adjusted incidence rateAge-specific incidence ratesHistologic typeLung cancer incidenceLung cancerIncidence rateBirth cohortRecent birth cohortsIncidence patternsObserved time trendsCell carcinomaCancer incidenceTime trendsConnecticut Tumor RegistryIncidence of adenocarcinomaSmall cell carcinomaSquamous cell carcinomaLung cancer casesRecent epidemiologic studiesDifferent histologic typesDifferent incidence patternsObserved incidence patternsTumor RegistryAge‐period‐cohort modelling of large‐bowel‐cancer incidence by anatomic sub‐site and sex in Denmark
Dubrow R, Johansen C, Skov T, Holford T. Age‐period‐cohort modelling of large‐bowel‐cancer incidence by anatomic sub‐site and sex in Denmark. International Journal Of Cancer 1994, 58: 324-329. PMID: 8050812, DOI: 10.1002/ijc.2910580303.Peer-Reviewed Original ResearchConceptsConnecticut Tumor RegistryDanish Cancer RegistryEtiologic distinctionsSigmoid colonCancer incidenceCohort modellingCohort patternsAnalytical epidemiologic studiesMalignant melanoma incidence in Connecticut (United States): time trends and age-period-cohort modeling by anatomic site
Chen Y, Zheng T, Holford T, Berwick M, Dubrow R. Malignant melanoma incidence in Connecticut (United States): time trends and age-period-cohort modeling by anatomic site. Cancer Causes & Control 1994, 5: 341-350. PMID: 8080946, DOI: 10.1007/bf01804985.Peer-Reviewed Original ResearchConceptsCutaneous malignant melanomaAnatomic sitesUpper limbPopulation-based Connecticut Tumor RegistryCohort patternsConnecticut Tumor RegistryMale-female ratioMalignant melanoma incidenceTime trendsCMM incidenceNeck melanomaTumor RegistryIncident casesMalignant melanomaMelanoma incidenceEtiologic distinctionsCarcinogenic exposuresLower limbsLargest absolute increaseMelanomaCohort modelingAbsolute increaseIncidenceLimbLargest relative increaseTime trends in the incidence of renal carcinoma: Analysis of connecticut tumor registry data, 1935‐1989
Katz D, Zheng T, Holford T, Flannery J. Time trends in the incidence of renal carcinoma: Analysis of connecticut tumor registry data, 1935‐1989. International Journal Of Cancer 1994, 58: 57-63. PMID: 8014016, DOI: 10.1002/ijc.2910580111.Peer-Reviewed Original ResearchConceptsTransitional cell carcinomaConnecticut Tumor RegistryCell carcinomaIncidence rateRenal cancerPopulation-based cancer registriesIncidence of adenocarcinomaTime trendsCohort effectsRegression modellingEffect of ageTumor RegistryCancer RegistryIncident casesUrinary tractRenal carcinomaBirth cohortCarcinomaAdenocarcinomaRate of riseIncidenceNegative cohort effectRegistryCancerMales
1993
The time trend and age—period—cohort effects on incidence of adenocarcinoma of the stomach in connecticut from 1955–1989
Zheng T, Mayne S, Holford T, Boyle P, Liu W, Chen Y, Mador M, Flannery J. The time trend and age—period—cohort effects on incidence of adenocarcinoma of the stomach in connecticut from 1955–1989. Cancer 1993, 72: 330-340. PMID: 8319166, DOI: 10.1002/1097-0142(19930715)72:2<330::aid-cncr2820720205>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsDistal stomachGastric cardiaObserved time trendsRisk factorsIncidence rateBirth cohortAge-adjusted incidence ratesTime trendsDifferent epidemiologic featuresFuture analytic studiesIncrease of adenocarcinomaConnecticut Tumor RegistryIncidence of adenocarcinomaRisk of adenocarcinomaBirth-cohort phenomenonRegression modelingUnited States populationUnspecified subsiteRetinol intakeHiatal herniaTumor RegistryEpidemiologic featuresAlcohol intakeIncident casesEtiologic factorsAge‐period‐cohort modelling of large‐bowel‐cancer incidence by anatomic sub‐site and sex in connecticut
Dubrow R, Bernstein J, Holford T. Age‐period‐cohort modelling of large‐bowel‐cancer incidence by anatomic sub‐site and sex in connecticut. International Journal Of Cancer 1993, 53: 907-913. PMID: 8473049, DOI: 10.1002/ijc.2910530607.Peer-Reviewed Original ResearchConceptsLeft colonCohort patternsTransverse colonLarge bowelCancer incidenceEtiologic distinctionsConnecticut Tumor RegistryTumor RegistrySigmoid colonCancer casesCohort modellingBirth cohortConnecticut residentsColonRectumCohort modelSexBowelIncidenceDiagnosisMalesFemalesCommon patternRegistryCohort
1992
Time trend and age-period-cohort effects on incidence of esophageal cancer in Connecticut, 1935–89
Zheng T, Mayne S, Holford T, Boyle P, Liu W, Chen Y, Mador M, Flannery J. Time trend and age-period-cohort effects on incidence of esophageal cancer in Connecticut, 1935–89. Cancer Causes & Control 1992, 3: 481-492. PMID: 1525329, DOI: 10.1007/bf00051361.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaIncidence rateCell carcinomaEsophageal cancerBirth cohortOverall age-adjusted incidence rateAge-adjusted incidence ratesConnecticut Tumor RegistryEsophageal cancer casesTime trendsEsophageal cancer ratesObserved time trendsGastric cardiaHistologic typeTumor RegistryIncident casesCancer ratesCancer casesAdenocarcinomaIncidence patternsEsophagusCancerLower thirdRegression modelingWhite malesEpidemiology of non‐Hodgkin lymphoma in connecticut 1935‐1988
Zheng T, Mayne S, Boyle P, Holford T, Liu W, Flannery J. Epidemiology of non‐Hodgkin lymphoma in connecticut 1935‐1988. Cancer 1992, 70: 840-849. PMID: 1643616, DOI: 10.1002/1097-0142(19920815)70:4<840::aid-cncr2820700420>3.0.co;2-i.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaAge-adjusted incidence ratesAge-specific incidence ratesConnecticut Tumor RegistryIncidence rateYears of ageRisk factorsAge groupsCases of NHLDiffuse non-Hodgkin's lymphomaAnalytical epidemiologic studiesHigh incidence rateBirth cohort effectsOlder age groupsRecent birth cohortsReports of increasesLymph nodesTumor RegistryHistologic subtypeCohort examinationNHL casesAnatomic sitesEpidemiologic studiesMortality rateBirth cohort
1988
Patterns of invasive melanoma in the connecticut tumor registry. Is the long‐term increase real?
Roush G, Schymura M, Holford T. Patterns of invasive melanoma in the connecticut tumor registry. Is the long‐term increase real? Cancer 1988, 61: 2586-2595. PMID: 3365679, DOI: 10.1002/1097-0142(19880615)61:12<2586::aid-cncr2820611233>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsConnecticut Tumor RegistryProportion of casesIncidence rateTumor RegistryCase ascertainmentBirth cohortPopulation-based incidence dataInvasive cutaneous malignant melanomaPeriod of diagnosisCutaneous malignant melanomaPatterns of changeMalignant melanomaInvasive melanomaCohort curvesAge groupsDisease riskAnalysis of ageIncidence dataMelanomaRegistryCohortDiagnosisArtifactual changesAscertainmentLong-term increase