1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-CareMethylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Neurosurgical FOCUS 1998, 5: e1. DOI: 10.3171/foc.1998.5.3.1.Peer-Reviewed Original ResearchAcute spinal cord injuryHours of injurySpinal cord injuryFunctional recoveryCord injuryMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMethods PatientsMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-Care
1993
Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery
Peduzzi P, Wittes J, Detre K, Holford T. Analysis as‐randomized and the problem of non‐adherence: An example from the veterans affairs randomized trial of coronary artery bypass surgery. Statistics In Medicine 1993, 12: 1185-1195. PMID: 8210821, DOI: 10.1002/sim.4780121302.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryArtery bypass surgeryTreatment groupsAlternative treatment groupBypass surgeryTreatment changesVeterans Administration Cooperative StudyTime of randomizationRandomized clinical trialsTreat analysisClinical trialsOutcome eventsRandom treatment assignmentCooperative StudyVeterans AffairsTreatment assignmentTherapySurgeryTrialsGroupPatients
1991
Intent-to-treat analysis and the problem of crossovers An example from the Veterans Administration coronary bypass surgery study
Peduzzi P, Detre K, Wittes J, Holford T. Intent-to-treat analysis and the problem of crossovers An example from the Veterans Administration coronary bypass surgery study. Journal Of Thoracic And Cardiovascular Surgery 1991, 101: 481-487. PMID: 1999942, DOI: 10.1016/s0022-5223(19)36731-5.Peer-Reviewed Original ResearchConceptsTreat analysisTreatment changesVeterans Administration Cooperative StudyDate of randomizationIschemic heart diseaseRandomized clinical trialsNew treatment groupEffect of treatmentStable anginaSurgical therapyMedical therapySurgical treatmentInitial treatmentSurgical interventionSurgery StudyMajor trialsHeart diseaseClinical trialsTreatment groupsCooperative StudySurvival dataTreatmentTherapyTrialsAdherence
1987
Comparison of the logistic and Cox regression models when outcome is determined in all patients after a fixed period of time
Peduzzi P, Holford T, Detre K, Chan Y. Comparison of the logistic and Cox regression models when outcome is determined in all patients after a fixed period of time. Journal Of Clinical Epidemiology 1987, 40: 761-767. PMID: 3597677, DOI: 10.1016/0021-9681(87)90127-5.Peer-Reviewed Original Research
1986
A Randomized Clinical Trial of the Insulin Pump vs Intensive Conventional Therapy in Diabetic Pregnancies
Coustan D, Reece E, Sherwin R, Rudolf M, Bates S, Sockin S, Holford T, Tamborlane W. A Randomized Clinical Trial of the Insulin Pump vs Intensive Conventional Therapy in Diabetic Pregnancies. JAMA 1986, 255: 631-636. PMID: 3511311, DOI: 10.1001/jama.1986.03370050073024.Peer-Reviewed Original ResearchConceptsDiabetic womenGlucose levelsIntensive conventional insulin therapyInpatient clinical research centerExcellent metabolic controlPregnant diabetic womenConventional insulin therapyClinical Research CenterMean glucose levelPrevention of hyperglycemiaHome glucose monitoringIntensive conventional therapyFrequent telephone contactChemical hypoglycemiaPerinatal outcomesSymptomatic hypoglycemiaDiabetic controlDiabetic pregnanciesInsulin therapyGlycemic excursionsHemoglobin levelsConventional therapyClinical trialsInsulin administrationTelephone contact