2015
How could preventive therapy affect the prevalence of drug resistance? Causes and consequences
Kunkel A, Colijn C, Lipsitch M, Cohen T. How could preventive therapy affect the prevalence of drug resistance? Causes and consequences. Philosophical Transactions Of The Royal Society B Biological Sciences 2015, 370: 20140306. PMID: 25918446, PMCID: PMC4424438, DOI: 10.1098/rstb.2014.0306.Peer-Reviewed Original ResearchMeSH KeywordsAntibiotic ProphylaxisCommunicable Disease ControlComputer SimulationDrug Resistance, MicrobialHumansInfectionsModels, TheoreticalPrevalenceConceptsPreventative therapyDrug resistanceDrug-sensitive pathogensProphylactic antimicrobial therapyLong-term prevalenceSmall pilot studyActive diseaseOverall prevalenceAntimicrobial therapyPrevalencePilot studyTherapyPopulation-level changesPotential population-level effectsDirect effectLevel of coveragePopulation-level effectsHIVTuberculosisMalariaDiseaseCareThe potential impact of coinfection on antimicrobial chemotherapy and drug resistance
Birger RB, Kouyos RD, Cohen T, Griffiths EC, Huijben S, Mina MJ, Volkova V, Grenfell B, Metcalf CJE. The potential impact of coinfection on antimicrobial chemotherapy and drug resistance. Trends In Microbiology 2015, 23: 537-544. PMID: 26028590, PMCID: PMC4835347, DOI: 10.1016/j.tim.2015.05.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoinfectionDrug Resistance, MicrobialHost-Pathogen InteractionsHumansImmunologic FactorsMicrobial InteractionsModels, Biological
2014
The path of least resistance: aggressive or moderate treatment?
Kouyos RD, Metcalf CJ, Birger R, Klein EY, Wiesch P, Ankomah P, Arinaminpathy N, Bogich TL, Bonhoeffer S, Brower C, Chi-Johnston G, Cohen T, Day T, Greenhouse B, Huijben S, Metlay J, Mideo N, Pollitt LC, Read AF, Smith DL, Standley C, Wale N, Grenfell B. The path of least resistance: aggressive or moderate treatment? Proceedings Of The Royal Society B 2014, 281: 20140566. PMID: 25253451, PMCID: PMC4211439, DOI: 10.1098/rspb.2014.0566.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Infective AgentsBiological EvolutionDrug Resistance, MicrobialHumansInfectionsMicrobiota