2024
Identifying local foci of tuberculosis transmission in Moldova using a spatial multinomial logistic regression model
Lan Y, Crudu V, Ciobanu N, Codreanu A, Chitwood M, Sobkowiak B, Warren J, Cohen T. Identifying local foci of tuberculosis transmission in Moldova using a spatial multinomial logistic regression model. EBioMedicine 2024, 102: 105085. PMID: 38531172, PMCID: PMC10987885, DOI: 10.1016/j.ebiom.2024.105085.Peer-Reviewed Original ResearchConceptsPatterns of spatial aggregationMtb strainsMDR-TBLogistic regression modelsGenome Epidemiology StudySpecific strainsMultidrug-resistant tuberculosisTreated TB casesNational Institute of AllergyMDR phenotypeRegression modelsM. tuberculosisInstitute of AllergyMultinomial logistic regression modelUS National Institutes of HealthNational Institutes of HealthMDR diseasePublic health concernAssociated with local transmissionIncident TBInstitutes of HealthMtbResistant tuberculosisStrainDiagnosing TB
2020
Transmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis.
Crawford FW, Marx FM, Zelner J, Cohen T. Transmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis. Epidemiology 2020, 31: 238-247. PMID: 31764276, PMCID: PMC7718772, DOI: 10.1097/ede.0000000000001143.Peer-Reviewed Original ResearchConceptsSusceptible household contactsHousehold contactsTB casesBacillus Calmette-Guérin (BCG) vaccinationInfected household contactsIsoniazid preventive therapyActive tuberculosis casesCulture-positive casesRisk of diseaseCohort studyMicrobiological confirmationPreventive therapyTuberculosis casesRisk factorsInfection resultsAdult contactsInfection riskInfectious diseasesLogistic regressionRate of transmissionTransmissible diseasesDiseaseIndividual-level characteristicsHigher hazardDisease susceptibility
2017
Protective effects of household-based TB interventions are robust to neighbourhood-level variation in exposure risk in Lima, Peru: a model-based analysis
Zelner J, Murray M, Becerra M, Galea J, Lecca L, Calderon R, Yataco R, Zhang Z, Cohen T. Protective effects of household-based TB interventions are robust to neighbourhood-level variation in exposure risk in Lima, Peru: a model-based analysis. International Journal Of Epidemiology 2017, 47: 185-192. PMID: 29025111, DOI: 10.1093/ije/dyx171.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyLatent TB infectionTB casesHousehold contactsHousehold exposureTB diseaseHealth centersPopulation-based prospective cohort studyHigh-risk household contactsMore casesBlanket screeningIncident pulmonary tuberculosisIncident TB diseasePositive household contactsProspective cohort studyTB screening programPublic Health CenterIncident tuberculosisTB infectionCohort studyPreventive therapyPulmonary tuberculosisTB incidenceSkin testTB risk
2014
Geographical heterogeneity of multidrug-resistant tuberculosis in Georgia, January 2009 to June 2011.
Jenkins HE, Gegia M, Furin J, Kalandadze I, Nanava U, Chakhaia T, Cohen T. Geographical heterogeneity of multidrug-resistant tuberculosis in Georgia, January 2009 to June 2011. Eurosurveillance 2014, 19 PMID: 24679722, PMCID: PMC4090679, DOI: 10.2807/1560-7917.es2014.19.11.20743.Peer-Reviewed Original ResearchConceptsMultidrug-resistant TBMDR-TB risk factorsTB casesRisk factorsMDR-TB incidenceMDR-TB riskMDR-TB transmissionMDR-TB casesMultidrug-resistant tuberculosisTreatment-naïve individualsMDR-TB burdenTuberculosis casesHigh riskTargeted interventionsSurveillance dataGeographical heterogeneityRegression modellingInterventionRiskRural areasCasesTuberculosisIncidencePercentage
2012
Assessing spatial heterogeneity of multidrug-resistant tuberculosis in a high-burden country
Jenkins HE, Plesca V, Ciobanu A, Crudu V, Galusca I, Soltan V, Serbulenco A, Zignol M, Dadu A, Dara M, Cohen T. Assessing spatial heterogeneity of multidrug-resistant tuberculosis in a high-burden country. European Respiratory Journal 2012, 42: 1291-1301. PMID: 23100496, PMCID: PMC3800490, DOI: 10.1183/09031936.00111812.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisMDR-TB riskMDR-TB risk factorsNational TB surveillance dataMDR-TB incidenceTB surveillance dataMDR-TB casesHigh-burden countriesMDR-TB burdenDistribution of casesTB casesTuberculosis casesRisk of resistanceRisk factorsGreater riskSubstantial geographical variationSurveillance dataAppropriate targetingTesting coverageRiskTuberculosisBurdenHigh percentageLocal mechanismsPatientsUse of Spatial Information to Predict Multidrug Resistance in Tuberculosis Patients, Peru - Volume 18, Number 5—May 2012 - Emerging Infectious Diseases journal - CDC
Lin HH, Shin SS, Contreras C, Asencios L, Paciorek CJ, Cohen T. Use of Spatial Information to Predict Multidrug Resistance in Tuberculosis Patients, Peru - Volume 18, Number 5—May 2012 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2012, 18: 811-813. PMID: 22516236, PMCID: PMC3358052, DOI: 10.3201/eid1805.111467.Peer-Reviewed Original ResearchOutcomes among tuberculosis patients with isoniazid resistance in Georgia, 2007-2009.
Gegia M, Cohen T, Kalandadze I, Vashakidze L, Furin J. Outcomes among tuberculosis patients with isoniazid resistance in Georgia, 2007-2009. The International Journal Of Tuberculosis And Lung Disease 2012, 16: 812-6. PMID: 22507372, PMCID: PMC3786434, DOI: 10.5588/ijtld.11.0637.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntitubercular AgentsChi-Square DistributionDrug Resistance, BacterialDrug Therapy, CombinationEthambutolFemaleGeorgia (Republic)HumansIsoniazidLogistic ModelsMaleMicrobial Sensitivity TestsMiddle AgedMultivariate AnalysisMycobacterium tuberculosisPredictive Value of TestsPyrazinamideRetrospective StudiesRifampinRisk AssessmentRisk FactorsSputumTime FactorsTreatment OutcomeTuberculosisConceptsPulmonary tuberculosisPrevious treatmentOutcomes of patientsPulmonary TB patientsSubset of patientsRetrospective record reviewForms of tuberculosisFirst-line drugsHigh TB ratesDrug-resistant formsLower ratesLow tuberculosisTB patientsTuberculosis patientsOptimal management strategyTreatment regimenRecord reviewTB ratesTreatment successTreatment outcomesCountry of GeorgiaPatientsIsoniazid resistanceTuberculosisDrug resistance
2008
Seasonality of Antibiotic-Resistant Streptococcus pneumoniae That Causes Acute Otitis Media: A Clue for an Antibiotic-Restriction Policy?
Dagan R, Barkai G, Givon-Lavi N, Sharf AZ, Vardy D, Cohen T, Lipsitch M, Greenberg D. Seasonality of Antibiotic-Resistant Streptococcus pneumoniae That Causes Acute Otitis Media: A Clue for an Antibiotic-Restriction Policy? The Journal Of Infectious Diseases 2008, 197: 1094-1102. PMID: 18419528, PMCID: PMC2652754, DOI: 10.1086/528995.Peer-Reviewed Original Research