2019
Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil
Mabud TS, de Lourdes Delgado Alves M, Ko AI, Basu S, Walter KS, Cohen T, Mathema B, Colijn C, Lemos E, Croda J, Andrews JR. Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil. PLOS Medicine 2019, 16: e1002737. PMID: 30677013, PMCID: PMC6345418, DOI: 10.1371/journal.pmed.1002737.Peer-Reviewed Original ResearchConceptsIncidence of TBPrison-based interventionsTB incidenceGeneral populationTB casesCox proportional hazards modelNew TB casesControl of tuberculosisProportional hazards modelPaucity of dataTime of incarcerationTB burdenTB screeningTB riskTB transmissionTB ratesTB epidemicAdministrative databasesCommunity incidenceTuberculosis epidemicHazards modelTB databaseIncidenceEpidemiological contextIntervention
2016
Connectivity of diagnostic technologies: improving surveillance and accelerating tuberculosis elimination
Andre E, Isaacs C, Affolabi D, Alagna R, Brockmann D, de Jong BC, Cambau E, Churchyard G, Cohen T, Delmee M, Delvenne JC, Farhat M, Habib A, Holme P, Keshavjee S, Khan A, Lightfoot P, Moore D, Moreno Y, Mundade Y, Pai M, Patel S, Nyaruhirira AU, Rocha LE, Takle J, Trébucq A, Creswell J, Boehme C. Connectivity of diagnostic technologies: improving surveillance and accelerating tuberculosis elimination. The International Journal Of Tuberculosis And Lung Disease 2016, 20: 999-1003. PMID: 27393530, PMCID: PMC4937753, DOI: 10.5588/ijtld.16.0015.Peer-Reviewed Original ResearchRapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study
Colman RE, Anderson J, Lemmer D, Lehmkuhl E, Georghiou SB, Heaton H, Wiggins K, Gillece JD, Schupp JM, Catanzaro DG, Crudu V, Cohen T, Rodwell TC, Engelthaler DM. Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study. Journal Of Clinical Microbiology 2016, 54: 2058-2067. PMID: 27225403, PMCID: PMC4963505, DOI: 10.1128/jcm.00535-16.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleGenotyping TechniquesHigh-Throughput Nucleotide SequencingHumansMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisPharmaceutical PreparationsPilot ProjectsSequence Analysis, DNASpecimen HandlingSputumTime FactorsYoung AdultConceptsDrug-resistant tuberculosisPatient sputum samplesDrug resistance profilesSputum samplesDrug-resistant Mycobacterium tuberculosis isolatesPhenotypic drug susceptibility testing resultsDrug susceptibility testing resultsEvidence-based treatment plansResistance profilesMajor global health concernRapid drug susceptibility testingMycobacterium tuberculosis isolatesNext-generation sequencingClinical samplesAmplification of resistanceDrug susceptibility testingTargeted Next-Generation SequencingMycobacterium tuberculosis DNAGlobal health concernSusceptibility testing resultsSame clinical samplePhenotypic DSTInfectious causesTreatment outcomesTuberculosis isolates
2014
Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts
Huang CC, Tchetgen ET, Becerra MC, Cohen T, Galea J, Calderon R, Yataco R, Contreras C, Zhang ZB, Lecca L, Murray M. Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts. The International Journal Of Tuberculosis And Lung Disease 2014, 18: 1285-1291. PMID: 25299859, DOI: 10.5588/ijtld.14.0309.Peer-Reviewed Original ResearchConceptsLatent tuberculous infectionTuberculin skin testTB patientsIndex caseChild household contactsDrug-susceptible TBIndex TB patientsObservational cohort studySecondhand smoke exposureRisk of transmissionPoisson regression modelsHousehold contactsCohort studyTST positivityTuberculosis patientsTuberculous infectionSmoke exposureSmoking statusTuberculosis casesCigarette smokingSkin testRisk factorsPatientsInfection statusTime pointsAssessment of the patient, health system, and population effects of Xpert MTB/RIF and alternative diagnostics for tuberculosis in Tanzania: an integrated modelling approach
Langley I, Lin HH, Egwaga S, Doulla B, Ku CC, Murray M, Cohen T, Squire SB. Assessment of the patient, health system, and population effects of Xpert MTB/RIF and alternative diagnostics for tuberculosis in Tanzania: an integrated modelling approach. The Lancet Global Health 2014, 2: e581-e591. PMID: 25304634, DOI: 10.1016/s2214-109x(14)70291-8.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioHigh incremental costIncremental costLED fluorescence microscopyCost-effectiveness ratioPay thresholdsFull rolloutContext of TanzaniaCost-effective optionHealth policy formulationPolicy formulationDifferent diagnostic optionsIntegrated modelling approachModelling approachAdditional costHealth systemCostAlternative diagnosticsIntegrated modelXpert MTB/RIFPopulation effectsMTB/RIFPresumptive tuberculosis casesWillingnessUse of XpertHigh risk and rapid appearance of multidrug resistance during tuberculosis treatment in Moldova.
Jenkins HE, Crudu V, Soltan V, Ciobanu A, Domente L, Cohen T. High risk and rapid appearance of multidrug resistance during tuberculosis treatment in Moldova. European Respiratory Journal 2014, 43: 1132-41. PMID: 24558181, PMCID: PMC4005038, DOI: 10.1183/09031936.00203613.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisMDR-TB diagnosisMDR-TB casesTB treatmentFirst-line TB drugsAmbulatory TB treatmentMDR-TB riskDrug susceptibility testingNosocomial transmissionInitial diagnosisPercentage of individualsTB drugsTuberculosis treatmentEarly treatmentHigh riskSputum specimensSurveillance databasePrevious incarcerationDrug resistanceMultidrug resistanceDiagnosisTreatmentBaseline resistanceRapid appearanceRisk
2013
Risk factors and timing of default from treatment for non-multidrug-resistant tuberculosis in Moldova
Jenkins HE, Ciobanu A, Plesca V, Crudu V, Galusca I, Soltan V, Cohen T. Risk factors and timing of default from treatment for non-multidrug-resistant tuberculosis in Moldova. The International Journal Of Tuberculosis And Lung Disease 2013, 17: 373-380. PMID: 23407226, PMCID: PMC3710709, DOI: 10.5588/ijtld.12.0464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntitubercular AgentsContinuity of Patient CareFemaleHumansInstitutionalizationLeast-Squares AnalysisLinear ModelsMaleMedication AdherenceMoldovaMultivariate AnalysisPatient DischargePrisonersProportional Hazards ModelsRetrospective StudiesRisk FactorsSocioeconomic FactorsTime FactorsTreatment OutcomeTuberculosisConceptsMultidrug-resistant tuberculosisMDR-TB patientsRisk factorsHighest MDR-TB ratesDrug resistanceGreater lung pathologyMDR-TB ratesAnti-tuberculosis treatmentIndependent risk factorHuman immunodeficiency virusTB drug resistanceContinuity of careRoutine surveillance dataTuberculosis patientsResistant tuberculosisImmunodeficiency virusLung pathologyTreatment adherenceRetrospective analysisHigh riskPatientsSociodemographic factorsCommunity careSurveillance dataStudy period
2012
Outcomes among tuberculosis patients with isoniazid resistance in Georgia, 2007-2009.
Gegia M, Cohen T, Kalandadze I, Vashakidze L, Furin J. Outcomes among tuberculosis patients with isoniazid resistance in Georgia, 2007-2009. The International Journal Of Tuberculosis And Lung Disease 2012, 16: 812-6. PMID: 22507372, PMCID: PMC3786434, DOI: 10.5588/ijtld.11.0637.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntitubercular AgentsChi-Square DistributionDrug Resistance, BacterialDrug Therapy, CombinationEthambutolFemaleGeorgia (Republic)HumansIsoniazidLogistic ModelsMaleMicrobial Sensitivity TestsMiddle AgedMultivariate AnalysisMycobacterium tuberculosisPredictive Value of TestsPyrazinamideRetrospective StudiesRifampinRisk AssessmentRisk FactorsSputumTime FactorsTreatment OutcomeTuberculosisConceptsPulmonary tuberculosisPrevious treatmentOutcomes of patientsPulmonary TB patientsSubset of patientsRetrospective record reviewForms of tuberculosisFirst-line drugsHigh TB ratesDrug-resistant formsLower ratesLow tuberculosisTB patientsTuberculosis patientsOptimal management strategyTreatment regimenRecord reviewTB ratesTreatment successTreatment outcomesCountry of GeorgiaPatientsIsoniazid resistanceTuberculosisDrug resistanceThe dynamics of sexual contact networks: Effects on disease spread and control
Robinson K, Cohen T, Colijn C. The dynamics of sexual contact networks: Effects on disease spread and control. Theoretical Population Biology 2012, 81: 89-96. PMID: 22248701, PMCID: PMC3328800, DOI: 10.1016/j.tpb.2011.12.009.Peer-Reviewed Original ResearchConceptsDuration of infectiousnessHigh-activity individualsBehavioral interventionsBehavioral risk factorsControl of STDsHigh-risk individualsDifferent risk groupsWidespread screening programsHigh-risk subpopulationsPopulation-wide interventionsSexual network structureIndividual-level riskRisk factorsRisk groupsScreening programRisk subpopulationsGreater relative decreaseDynamics of transmissionSexual contactSexual partnershipsBiomedical interventionsInfectiousnessLonger durationComparable benefitsIntervention
2011
A modelling framework to support the selection and implementation of new tuberculosis diagnostic tools [State of the art series. Operational research. Number 8 in the series]
Lin HH, Langley I, Mwenda R, Doulla B, Egwaga S, Millington KA, Mann GH, Murray M, Squire SB, Cohen T. A modelling framework to support the selection and implementation of new tuberculosis diagnostic tools [State of the art series. Operational research. Number 8 in the series]. The International Journal Of Tuberculosis And Lung Disease 2011, 15: 996-1004. PMID: 21740663, DOI: 10.5588/ijtld.11.0062.Peer-Reviewed Original ResearchConceptsDiagnostic strategiesHealth systemTB transmission dynamicsDiagnosis of tuberculosisHealth system requirementsDiagnostic toolHealth system componentsPolicy makersNew diagnostic strategiesHealth care infrastructureNovel diagnostic toolPatient outcomesDifferent epidemiologyJoint modelling frameworkModelling frameworkTest characteristicsCare infrastructureTransmission dynamicsRational choiceTuberculosisTechnological innovationStrategy decisionsDifficult decisionsMakersRecent introductionQuantifying the Burden and Trends of Isoniazid Resistant Tuberculosis, 1994–2009
Jenkins HE, Zignol M, Cohen T. Quantifying the Burden and Trends of Isoniazid Resistant Tuberculosis, 1994–2009. PLOS ONE 2011, 6: e22927. PMID: 21829557, PMCID: PMC3146514, DOI: 10.1371/journal.pone.0022927.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyIncident TB casesTB casesHIV prevalence countriesHigh HIV prevalence countriesPrevalence countriesHigh HIV prevalence areasRetreatment TB casesHIV prevalence areasIsoniazid-resistant tuberculosisControl of tuberculosisEffect of INHObserved time trendsWorld Health OrganizationPreventive therapyResistant tuberculosisIncident casesTreatment successPrevalence areasIsoniazid resistanceMultidrug resistanceHealth OrganizationTuberculosisINHNational dataTest and treat in HIV: success could depend on rapid detection
Cohen T, Corbett EL. Test and treat in HIV: success could depend on rapid detection. The Lancet 2011, 378: 204-206. PMID: 21684592, DOI: 10.1016/s0140-6736(11)60896-9.Peer-Reviewed Original ResearchEpidemiologic Inference From the Distribution of Tuberculosis Cases in Households in Lima, Peru
Brooks-Pollock E, Becerra MC, Goldstein E, Cohen T, Murray MB. Epidemiologic Inference From the Distribution of Tuberculosis Cases in Households in Lima, Peru. The Journal Of Infectious Diseases 2011, 203: 1582-1589. PMID: 21592987, PMCID: PMC3096792, DOI: 10.1093/infdis/jir162.Peer-Reviewed Original ResearchConceptsHousehold contactsCommunity transmissionHousehold casesPrevious TB infectionNew TB casesHigh-incidence settingsHousehold risk factorsClustering of casesDistribution of casesMajority of casesRisk of diseaseTB infectionActive tuberculosisTB casesCase patientsProtective immunityTuberculosis casesHousehold transmissionRisk factorsNumber of casesHousehold exposureNatural historyTuberculosisCross-sectional dataImmunityModelling the performance of isoniazid preventive therapy for reducing tuberculosis in HIV endemic settings: the effects of network structure
Mills HL, Cohen T, Colijn C. Modelling the performance of isoniazid preventive therapy for reducing tuberculosis in HIV endemic settings: the effects of network structure. Journal Of The Royal Society Interface 2011, 8: 1510-1520. PMID: 21508012, PMCID: PMC3163428, DOI: 10.1098/rsif.2011.0160.Peer-Reviewed Original ResearchConceptsTB diseaseLatent M. tuberculosis infectionEffects of IptHIV-endemic settingsActive tuberculosis diseaseIsoniazid preventive therapyIntact immune systemM. tuberculosis infectionWorld Health OrganizationPreventive therapyTB casesTuberculosis infectionTuberculosis diseaseClinical trialsEndemic settingsIPT programHigh riskLatent infectionSingle drugCommunity-wide levelRespiratory contactHIVImmune systemPopulation-level impactUse of IPTSpontaneous Emergence of Multiple Drug Resistance in Tuberculosis before and during Therapy
Colijn C, Cohen T, Ganesh A, Murray M. Spontaneous Emergence of Multiple Drug Resistance in Tuberculosis before and during Therapy. PLOS ONE 2011, 6: e18327. PMID: 21479171, PMCID: PMC3068161, DOI: 10.1371/journal.pone.0018327.Peer-Reviewed Original ResearchConceptsMultiple drug resistanceDrug resistanceInitial treatment regimensTB control programsAnti-TB drugsDrug-resistant formsEmergence of resistanceFunctional monotherapyTreatment regimensCombination therapyTB strainsTuberculosis treatmentTherapy rangeM. tbTB bacilliMultidrug resistanceM. tuberculosisDifferent antibioticsTherapyTuberculosisInfected hostControl programsResistant formsTBMonotherapy
2005
Incident Tuberculosis among Recent US Immigrants and Exogenous Reinfection - Volume 11, Number 5—May 2005 - Emerging Infectious Diseases journal - CDC
Cohen T, Murray M. Incident Tuberculosis among Recent US Immigrants and Exogenous Reinfection - Volume 11, Number 5—May 2005 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2005, 11: 725-728. PMID: 15890129, PMCID: PMC3320369, DOI: 10.3201/eid1105.041107.Peer-Reviewed Original Research
2004
Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness
Cohen T, Murray M. Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness. Nature Medicine 2004, 10: 1117-1121. PMID: 15378056, PMCID: PMC2652755, DOI: 10.1038/nm1110.Peer-Reviewed Original ResearchConceptsDrug-sensitive strainsMDR strainsMultidrug resistanceMultidrug-resistant M. tuberculosisM. tuberculosisMultidrug-resistant tuberculosisTuberculosis control effortsEmergence of resistanceTB controlFuture burdenMDR diseaseMDRTB strainsEpidemiological measuresTuberculosisMDRSmall subpopulationMDRTBControl programsBurdenSingle locus mutationsSequential acquisitionDisease