2023
Spatially-targeted tuberculosis screening has limited impact beyond household contact tracing in Lima, Peru: A model-based analysis
Havumaki J, Warren J, Zelner J, Menzies N, Calderon R, Contreras C, Lecca L, Becerra M, Murray M, Cohen T. Spatially-targeted tuberculosis screening has limited impact beyond household contact tracing in Lima, Peru: A model-based analysis. PLOS ONE 2023, 18: e0293519. PMID: 37903091, PMCID: PMC10615320, DOI: 10.1371/journal.pone.0293519.Peer-Reviewed Original Research
2020
Ongoing challenges to understanding multidrug- and rifampicin-resistant tuberculosis in children versus adults
McQuaid CF, Cohen T, Dean AS, Houben RMGJ, Knight GM, Zignol M, White RG. Ongoing challenges to understanding multidrug- and rifampicin-resistant tuberculosis in children versus adults. European Respiratory Journal 2020, 57: 2002504. PMID: 32855219, DOI: 10.1183/13993003.02504-2020.Peer-Reviewed Original ResearchConceptsMDR/RR-TBRR-TBOdds ratioPediatric TB casesGlobal TB epidemicRifampicin-resistant tuberculosisPopulation-representative surveyTB casesBurden countriesTB epidemicMost settingsTuberculosisDrug resistanceTransmission riskCountry-specific estimatesAdultsChildrenAgeFurther investigationMultidrugOddsFormer Soviet Union countriesSufficient dataSettingSoviet Union countriesTransmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis.
Crawford FW, Marx FM, Zelner J, Cohen T. Transmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis. Epidemiology 2020, 31: 238-247. PMID: 31764276, PMCID: PMC7718772, DOI: 10.1097/ede.0000000000001143.Peer-Reviewed Original ResearchConceptsSusceptible household contactsHousehold contactsTB casesBacillus Calmette-Guérin (BCG) vaccinationInfected household contactsIsoniazid preventive therapyActive tuberculosis casesCulture-positive casesRisk of diseaseCohort studyMicrobiological confirmationPreventive therapyTuberculosis casesRisk factorsInfection resultsAdult contactsInfection riskInfectious diseasesLogistic regressionRate of transmissionTransmissible diseasesDiseaseIndividual-level characteristicsHigher hazardDisease susceptibility
2019
Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study
Becerra MC, Huang CC, Lecca L, Bayona J, Contreras C, Calderon R, Yataco R, Galea J, Zhang Z, Atwood S, Cohen T, Mitnick CD, Farmer P, Murray M. Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study. The BMJ 2019, 367: l5894. PMID: 31649017, PMCID: PMC6812583, DOI: 10.1136/bmj.l5894.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsChildChild, PreschoolContact TracingDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceInfantInfant, NewbornIsoniazidKaplan-Meier EstimateMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisPeruProspective StudiesRifampinSputumTuberculin TestTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryYoung AdultConceptsDrug-sensitive tuberculosisMultidrug-resistant tuberculosisHousehold contactsProspective cohort studySensitive tuberculosisTuberculosis infectionResistant tuberculosisCohort studyTuberculosis diseaseHigh riskDrug-resistant Mycobacterium tuberculosisIncident tuberculosis diseasePhenotypic drug resistanceDistrict Health CenterResistant Mycobacterium tuberculosisDrug-susceptible strainsDrug resistance profilesActive diseasePulmonary tuberculosisDisease progressionGuideline producersHealth centersIndex patientsEffective treatmentPatients
2017
Polyclonal Pulmonary Tuberculosis Infections and Risk for Multidrug Resistance, Lima, Peru - Volume 23, Number 11—November 2017 - Emerging Infectious Diseases journal - CDC
Nathavitharana RR, Shi CX, Chindelevitch L, Calderon R, Zhang Z, Galea JT, Contreras C, Yataco R, Lecca L, Becerra MC, Murray MB, Cohen T. Polyclonal Pulmonary Tuberculosis Infections and Risk for Multidrug Resistance, Lima, Peru - Volume 23, Number 11—November 2017 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2017, 23: 1887-1890. PMID: 29048297, PMCID: PMC5652442, DOI: 10.3201/eid2311.170077.Peer-Reviewed Original ResearchConceptsTreatment of tuberculosisHost Mycobacterium tuberculosis diversityMultidrug-resistant TBInfectious Diseases journal - CDCPulmonary TB patientsPulmonary tuberculosis infectionTB patientsTuberculosis infectionPolyclonal infectionsSimple infectionMultidrug resistanceInfectionPatientsTuberculosisPrevalenceDiagnosisProtective effects of household-based TB interventions are robust to neighbourhood-level variation in exposure risk in Lima, Peru: a model-based analysis
Zelner J, Murray M, Becerra M, Galea J, Lecca L, Calderon R, Yataco R, Zhang Z, Cohen T. Protective effects of household-based TB interventions are robust to neighbourhood-level variation in exposure risk in Lima, Peru: a model-based analysis. International Journal Of Epidemiology 2017, 47: 185-192. PMID: 29025111, DOI: 10.1093/ije/dyx171.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyLatent TB infectionTB casesHousehold contactsHousehold exposureTB diseaseHealth centersPopulation-based prospective cohort studyHigh-risk household contactsMore casesBlanket screeningIncident pulmonary tuberculosisIncident TB diseasePositive household contactsProspective cohort studyTB screening programPublic Health CenterIncident tuberculosisTB infectionCohort studyPreventive therapyPulmonary tuberculosisTB incidenceSkin testTB risk
2015
Identifying Hotspots of Multidrug-Resistant Tuberculosis Transmission Using Spatial and Molecular Genetic Data
Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Manjourides J, Grenfell BT, Cohen T. Identifying Hotspots of Multidrug-Resistant Tuberculosis Transmission Using Spatial and Molecular Genetic Data. The Journal Of Infectious Diseases 2015, 213: 287-294. PMID: 26175455, PMCID: PMC4690150, DOI: 10.1093/infdis/jiv387.Peer-Reviewed Original ResearchConceptsMDR tuberculosisDrug susceptibilityTuberculosis casesMultidrug-resistant tuberculosis (MDR-TB) transmissionCulture-confirmed diseaseHealth Center areaProspective cohort studyCapita incidenceHousehold contactsCohort studyTuberculosis riskTuberculosis transmissionSymptomatic individualsHigh riskPositive culturesNumber tandem repeatRiskEtiologyFitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study
Salvatore PP, Becerra MC, Wiesch P, Hinkley T, Kaur D, Sloutsky A, Cohen T. Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study. The Journal Of Infectious Diseases 2015, 213: 149-155. PMID: 26092854, PMCID: PMC4676541, DOI: 10.1093/infdis/jiv347.Peer-Reviewed Original ResearchConceptsDrug resistance mutationsCase-control studyKatG Ser315Thr mutationMDR strainsMultiple case householdsResistance mutationsDrug resistance-associated mutationsMycobacterium tuberculosisMultidrug-resistant Mycobacterium tuberculosisSecondary household casesSer315Thr mutationMDR M. tuberculosisMultidrug-resistant tuberculosisMDR Mycobacterium tuberculosisResistance-associated polymorphismsLong-term prevalenceResistance-associated mutationsVivo fitness costsCase-control designEpidemiologic studiesHousehold casesTuberculosisExperimental modelM. tuberculosisMutations
2014
Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts
Huang CC, Tchetgen ET, Becerra MC, Cohen T, Galea J, Calderon R, Yataco R, Contreras C, Zhang ZB, Lecca L, Murray M. Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts. The International Journal Of Tuberculosis And Lung Disease 2014, 18: 1285-1291. PMID: 25299859, DOI: 10.5588/ijtld.14.0309.Peer-Reviewed Original ResearchConceptsLatent tuberculous infectionTuberculin skin testTB patientsIndex caseChild household contactsDrug-susceptible TBIndex TB patientsObservational cohort studySecondhand smoke exposureRisk of transmissionPoisson regression modelsHousehold contactsCohort studyTST positivityTuberculosis patientsTuberculous infectionSmoke exposureSmoking statusTuberculosis casesCigarette smokingSkin testRisk factorsPatientsInfection statusTime pointsAge-Specific Risks of Tuberculosis Infection From Household and Community Exposures and Opportunities for Interventions in a High-Burden Setting
Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Grenfell BT, Cohen T. Age-Specific Risks of Tuberculosis Infection From Household and Community Exposures and Opportunities for Interventions in a High-Burden Setting. American Journal Of Epidemiology 2014, 180: 853-861. PMID: 25190676, PMCID: PMC4188339, DOI: 10.1093/aje/kwu192.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionHousehold contactsAge-specific riskYears of ageTuberculosis infectionLarge population-based prospective cohort studyPopulation-based prospective cohort studyHousehold exposureBacillus Calmette-Guérin (BCG) vaccineIncident pulmonary tuberculosisCommunity exposureProspective cohort studyCalmette-Guérin vaccineHigh-burden settingsPublic Health CenterCommunity-based transmissionRisk of infectionCohort studyLTBI prevalencePreventive therapyPulmonary tuberculosisTuberculosis patientsTuberculosis casesHousehold transmissionExcess riskBacillus Calmette-Guérin and Isoniazid Preventive Therapy Protect Contacts of Patients with Tuberculosis
Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Grenfell BT, Cohen T. Bacillus Calmette-Guérin and Isoniazid Preventive Therapy Protect Contacts of Patients with Tuberculosis. American Journal Of Respiratory And Critical Care Medicine 2014, 189: 853-859. PMID: 24592878, PMCID: PMC4225829, DOI: 10.1164/rccm.201310-1896oc.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAntitubercular AgentsBCG VaccineChildChild, PreschoolContact TracingFemaleFollow-Up StudiesHumansInfantIsoniazidMaleMiddle AgedModels, StatisticalModels, TheoreticalMultivariate AnalysisOdds RatioPeruProspective StudiesTreatment OutcomeTuberculosis, PulmonaryYoung AdultConceptsIsoniazid preventive therapyAge-specific efficacyLatent TB infectionIncident tuberculosisHousehold contactsTB diseaseTB infectionPulmonary tuberculosisRisk ratioUse of IPTObservational prospective cohort studyBacillus Calmette-Guérin (BCG) vaccinationHigh TB burden settingsAdditional TB casesHIV-positive contactsIncident pulmonary tuberculosisHIV-negative childrenProspective cohort studyPublic Health CenterBacillus Calmette-GuérinYear-long followWorld Health OrganizationCohort studyPreventive therapyTB cases
2013
The Effect of HIV-Related Immunosuppression on the Risk of Tuberculosis Transmission to Household Contacts
Huang CC, Tchetgen ET, Becerra MC, Cohen T, Hughes KC, Zhang Z, Calderon R, Yataco R, Contreras C, Galea J, Lecca L, Murray M. The Effect of HIV-Related Immunosuppression on the Risk of Tuberculosis Transmission to Household Contacts. Clinical Infectious Diseases 2013, 58: 765-774. PMID: 24368620, PMCID: PMC3935504, DOI: 10.1093/cid/cit948.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHousehold contactsIndex patientsCD4 countTuberculosis patientsTuberculosis transmissionHIV-negative tuberculosis patientsHIV-negative patientsHIV-positive patientsDrug-sensitive tuberculosisTuberculin skin testingTuberculosis infection statusRisk of infectionCoinfected PatientsActive tuberculosisTuberculosis infectionHIV statusSkin testingImmunodeficiency virusRisk factorsRelative riskPatientsTuberculosisInfection statusInfectionA tale of two settings: the role of the Beijing genotype in the epidemiology of multidrug-resistant tuberculosis.
Stagg HR, Cohen T, Becerra MC, Anderson LF, Abubakar I. A tale of two settings: the role of the Beijing genotype in the epidemiology of multidrug-resistant tuberculosis. European Respiratory Journal 2013, 43: 632-5. PMID: 24036242, DOI: 10.1183/09031936.00140513.Peer-Reviewed Original Research
2012
Use of Spatial Information to Predict Multidrug Resistance in Tuberculosis Patients, Peru - Volume 18, Number 5—May 2012 - Emerging Infectious Diseases journal - CDC
Lin HH, Shin SS, Contreras C, Asencios L, Paciorek CJ, Cohen T. Use of Spatial Information to Predict Multidrug Resistance in Tuberculosis Patients, Peru - Volume 18, Number 5—May 2012 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2012, 18: 811-813. PMID: 22516236, PMCID: PMC3358052, DOI: 10.3201/eid1805.111467.Peer-Reviewed Original ResearchIdentifying multidrug resistant tuberculosis transmission hotspots using routinely collected data
Manjourides J, Lin HH, Shin S, Jeffery C, Contreras C, Santa Cruz J, Jave O, Yagui M, Asencios L, Pagano M, Cohen T. Identifying multidrug resistant tuberculosis transmission hotspots using routinely collected data. Tuberculosis 2012, 92: 273-279. PMID: 22401962, PMCID: PMC3323731, DOI: 10.1016/j.tube.2012.02.003.Peer-Reviewed Original ResearchConceptsDrug sensitivity testTransmission hotspotsRetreatment casesDrug-resistant tuberculosis epidemicRisk of MDRTime of diagnosisDrug-resistant diseaseTB casesResistant diseaseTuberculosis epidemicHigh riskUntreated casesProgrammatic dataMDRTBRiskMDRHigh levelsTargeted investigationGeographic areasCasesDiseaseDiagnosisSensitivity tests
2011
Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru - Volume 17, Number 6—June 2011 - Emerging Infectious Diseases journal - CDC
Cohen T, Murray M, Abubakar I, Zhang Z, Sloutsky A, Arteaga F, Chalco K, Franke MF, Becerra MC. Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru - Volume 17, Number 6—June 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 969-975. PMID: 21749756, PMCID: PMC3358204, DOI: 10.3201/eid1706.101471.Peer-Reviewed Original ResearchConceptsMDR-TB patientsMDR-TBMultidrug-resistant tuberculosisTB patientsOptimal treatment regimensMDR Mycobacterium tuberculosisDrug sensitivity testingHigh incidence areaRepetitive unit-variable number tandem repeatHousehold contactsTreatment regimensHousehold transmissionSecondary casesPatientsMycobacterium tuberculosisSensitivity testingCommunity exposureTuberculosisNumber tandem repeatTBSecond strainExposureRegimensSpoligotypingEpidemiologic Inference From the Distribution of Tuberculosis Cases in Households in Lima, Peru
Brooks-Pollock E, Becerra MC, Goldstein E, Cohen T, Murray MB. Epidemiologic Inference From the Distribution of Tuberculosis Cases in Households in Lima, Peru. The Journal Of Infectious Diseases 2011, 203: 1582-1589. PMID: 21592987, PMCID: PMC3096792, DOI: 10.1093/infdis/jir162.Peer-Reviewed Original ResearchConceptsHousehold contactsCommunity transmissionHousehold casesPrevious TB infectionNew TB casesHigh-incidence settingsHousehold risk factorsClustering of casesDistribution of casesMajority of casesRisk of diseaseTB infectionActive tuberculosisTB casesCase patientsProtective immunityTuberculosis casesHousehold transmissionRisk factorsNumber of casesHousehold exposureNatural historyTuberculosisCross-sectional dataImmunity
2010
Assessing spatiotemporal patterns of multidrug-resistant and drug-sensitive tuberculosis in a South American setting
LIN H, SHIN S, BLAYA JA, ZHANG Z, CEGIELSKI P, CONTRERAS C, ASENCIOS L, BONILLA C, BAYONA J, PACIOREK CJ, COHEN T. Assessing spatiotemporal patterns of multidrug-resistant and drug-sensitive tuberculosis in a South American setting. Epidemiology And Infection 2010, 139: 1784-1793. PMID: 21205434, PMCID: PMC3153578, DOI: 10.1017/s0950268810002797.Peer-Reviewed Original ResearchConceptsTB casesMDR diseaseMultidrug-resistant tuberculosis (MDR-TB) casesDrug-sensitive tuberculosisDrug-resistant diseaseDrug susceptibility testingMDR-TBMDR casesTuberculosis casesIncident casesSubgroup analysisInfection controlK statisticInfectious durationAppearance of resistanceDistricts of LimaSusceptibility testingDiseasePatientsTBUrban settingsCasesTuberculosisSettingMDR
2008
Personal digital assistants to collect tuberculosis bacteriology data in Peru reduce delays, errors, and workload, and are acceptable to users: cluster randomized controlled trial
Blaya JA, Cohen T, Rodríguez P, Kim J, Fraser HS. Personal digital assistants to collect tuberculosis bacteriology data in Peru reduce delays, errors, and workload, and are acceptable to users: cluster randomized controlled trial. International Journal Of Infectious Diseases 2008, 13: 410-418. PMID: 19097925, PMCID: PMC2673336, DOI: 10.1016/j.ijid.2008.09.015.Peer-Reviewed Original Research