2024
The impact of COVID-19 national lockdowns on drug-resistant tuberculosis in KwaZulu-Natal, South Africa: A spatial analysis
Harrington K, Gandhi N, Shah N, Naidoo K, Auld S, Andrews J, Brust J, Lutchminarain K, Coe M, Willis F, Campbell A, Cohen T, Jenness S, Waller L, Investigators O. The impact of COVID-19 national lockdowns on drug-resistant tuberculosis in KwaZulu-Natal, South Africa: A spatial analysis. Annals Of Epidemiology 2024, 97: 44-51. PMID: 39038747, PMCID: PMC11408097, DOI: 10.1016/j.annepidem.2024.07.044.Peer-Reviewed Original ResearchKwaZulu-Natal ProvinceTB diagnosisDrug resistanceBayesian conditional autoregressive modelProspective cohort studyKwaZulu-NatalCOVID-19 national lockdownDrug-resistant tuberculosisRate of diagnosisCOVID-19 mitigation strategiesStatistics South AfricaSpatial analysisSpatial distributionMunicipal characteristicsCohort studyDR-TBNotification ratesTB notificationsSouth AfricaSurface mappingRate of casesRelative-riskCOVID-19Conditional autoregressive modelSpatial correlation
2019
Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study
Becerra MC, Huang CC, Lecca L, Bayona J, Contreras C, Calderon R, Yataco R, Galea J, Zhang Z, Atwood S, Cohen T, Mitnick CD, Farmer P, Murray M. Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study. The BMJ 2019, 367: l5894. PMID: 31649017, PMCID: PMC6812583, DOI: 10.1136/bmj.l5894.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsChildChild, PreschoolContact TracingDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceInfantInfant, NewbornIsoniazidKaplan-Meier EstimateMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisPeruProspective StudiesRifampinSputumTuberculin TestTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryYoung AdultConceptsDrug-sensitive tuberculosisMultidrug-resistant tuberculosisHousehold contactsProspective cohort studySensitive tuberculosisTuberculosis infectionResistant tuberculosisCohort studyTuberculosis diseaseHigh riskDrug-resistant Mycobacterium tuberculosisIncident tuberculosis diseasePhenotypic drug resistanceDistrict Health CenterResistant Mycobacterium tuberculosisDrug-susceptible strainsDrug resistance profilesActive diseasePulmonary tuberculosisDisease progressionGuideline producersHealth centersIndex patientsEffective treatmentPatients
2017
Protective effects of household-based TB interventions are robust to neighbourhood-level variation in exposure risk in Lima, Peru: a model-based analysis
Zelner J, Murray M, Becerra M, Galea J, Lecca L, Calderon R, Yataco R, Zhang Z, Cohen T. Protective effects of household-based TB interventions are robust to neighbourhood-level variation in exposure risk in Lima, Peru: a model-based analysis. International Journal Of Epidemiology 2017, 47: 185-192. PMID: 29025111, DOI: 10.1093/ije/dyx171.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyLatent TB infectionTB casesHousehold contactsHousehold exposureTB diseaseHealth centersPopulation-based prospective cohort studyHigh-risk household contactsMore casesBlanket screeningIncident pulmonary tuberculosisIncident TB diseasePositive household contactsProspective cohort studyTB screening programPublic Health CenterIncident tuberculosisTB infectionCohort studyPreventive therapyPulmonary tuberculosisTB incidenceSkin testTB risk
2016
Within-Host Heterogeneity of Mycobacterium tuberculosis Infection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study
Cohen T, Chindelevitch L, Misra R, Kempner ME, Galea J, Moodley P, Wilson D. Within-Host Heterogeneity of Mycobacterium tuberculosis Infection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study. The Journal Of Infectious Diseases 2016, 213: 1796-1799. PMID: 26768249, PMCID: PMC4857469, DOI: 10.1093/infdis/jiw014.Peer-Reviewed Original ResearchConceptsMonths of treatmentMycobacterium tuberculosis infectionTuberculosis infectionTreatment responsePoor early treatment responseProspective cohort studyInitiation of treatmentM. tuberculosis infectionRepetitive units-variable numberEarly treatment responsePersistent culture positivityCohort studyClinical managementCulture positivityHigher oddsInfectionTuberculosisPrevalenceTreatmentMonthsResponsePatientsKwaZulu-NatalHost heterogeneityPositivity
2015
Identifying Hotspots of Multidrug-Resistant Tuberculosis Transmission Using Spatial and Molecular Genetic Data
Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Manjourides J, Grenfell BT, Cohen T. Identifying Hotspots of Multidrug-Resistant Tuberculosis Transmission Using Spatial and Molecular Genetic Data. The Journal Of Infectious Diseases 2015, 213: 287-294. PMID: 26175455, PMCID: PMC4690150, DOI: 10.1093/infdis/jiv387.Peer-Reviewed Original ResearchConceptsMDR tuberculosisDrug susceptibilityTuberculosis casesMultidrug-resistant tuberculosis (MDR-TB) transmissionCulture-confirmed diseaseHealth Center areaProspective cohort studyCapita incidenceHousehold contactsCohort studyTuberculosis riskTuberculosis transmissionSymptomatic individualsHigh riskPositive culturesNumber tandem repeatRiskEtiologyHIV burden in men who have sex with men: a prospective cohort study 2007–2012
Jia Z, Huang X, Wu H, Zhang T, Li N, Ding P, Sun Y, Liu Z, Wei F, Zhang H, Jiao Y, Ji Y, Zhang Y, Guo C, Li W, Mou D, Xia W, Li Z, Chen D, Yan H, Chen X, Zhao J, Meyers K, Cohen T, Mayer K, Salomon JA, Lu Z, Dye C. HIV burden in men who have sex with men: a prospective cohort study 2007–2012. Scientific Reports 2015, 5: 11205. PMID: 26135810, PMCID: PMC5393284, DOI: 10.1038/srep11205.Peer-Reviewed Original ResearchConceptsHIV infectionHIV-negative MSMProspective cohort studyHIV incidence ratesIntensive preventive interventionIncident HIVCohort studyHIV burdenHIV incidenceIncident casesRisk factorsIncidence rateEarly treatmentPrevalent casesChinese MSMHIVPreventive interventionsInfectionMSMFollowPerfect complianceMenEnrollmentSyphilisCohort
2014
Age-Specific Risks of Tuberculosis Infection From Household and Community Exposures and Opportunities for Interventions in a High-Burden Setting
Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Grenfell BT, Cohen T. Age-Specific Risks of Tuberculosis Infection From Household and Community Exposures and Opportunities for Interventions in a High-Burden Setting. American Journal Of Epidemiology 2014, 180: 853-861. PMID: 25190676, PMCID: PMC4188339, DOI: 10.1093/aje/kwu192.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionHousehold contactsAge-specific riskYears of ageTuberculosis infectionLarge population-based prospective cohort studyPopulation-based prospective cohort studyHousehold exposureBacillus Calmette-Guérin (BCG) vaccineIncident pulmonary tuberculosisCommunity exposureProspective cohort studyCalmette-Guérin vaccineHigh-burden settingsPublic Health CenterCommunity-based transmissionRisk of infectionCohort studyLTBI prevalencePreventive therapyPulmonary tuberculosisTuberculosis patientsTuberculosis casesHousehold transmissionExcess riskBacillus Calmette-Guérin and Isoniazid Preventive Therapy Protect Contacts of Patients with Tuberculosis
Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Grenfell BT, Cohen T. Bacillus Calmette-Guérin and Isoniazid Preventive Therapy Protect Contacts of Patients with Tuberculosis. American Journal Of Respiratory And Critical Care Medicine 2014, 189: 853-859. PMID: 24592878, PMCID: PMC4225829, DOI: 10.1164/rccm.201310-1896oc.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAntitubercular AgentsBCG VaccineChildChild, PreschoolContact TracingFemaleFollow-Up StudiesHumansInfantIsoniazidMaleMiddle AgedModels, StatisticalModels, TheoreticalMultivariate AnalysisOdds RatioPeruProspective StudiesTreatment OutcomeTuberculosis, PulmonaryYoung AdultConceptsIsoniazid preventive therapyAge-specific efficacyLatent TB infectionIncident tuberculosisHousehold contactsTB diseaseTB infectionPulmonary tuberculosisRisk ratioUse of IPTObservational prospective cohort studyBacillus Calmette-Guérin (BCG) vaccinationHigh TB burden settingsAdditional TB casesHIV-positive contactsIncident pulmonary tuberculosisHIV-negative childrenProspective cohort studyPublic Health CenterBacillus Calmette-GuérinYear-long followWorld Health OrganizationCohort studyPreventive therapyTB cases
2013
HIV burden in men who have sex with men: a prospective cohort study during 2007–12 in Beijing, China
Jia Z, Huang X, Wu H, Li N, Li Q, Liu Z, Cohen T, Mayer K, Dye C, Salomon J. HIV burden in men who have sex with men: a prospective cohort study during 2007–12 in Beijing, China. The Lancet 2013, 382: s19. DOI: 10.1016/s0140-6736(13)62267-9.Peer-Reviewed Original ResearchProspective cohort studyHIV infectionCondom useCasual partnershipsSteady partnershipsCohort studyHIV antibodiesHIV incidenceDisease burdenPrevalent casesStudy participantsCox proportional hazards modelLower HIV incidenceHIV-negative MSMProportional hazards modelConsistent condom useSexual behaviorSelf-reported condom useSpread of HIVPrevious serological testsUse of condomsLeast high school educationMost study participantsFinal visitBaseline visit