2024
Predictors of unsuccessful tuberculosis treatment outcomes in Brazil: an analysis of 259,484 patient records
Ryuk D, Pelissari D, Alves K, Oliveira P, Castro M, Cohen T, Sanchez M, Menzies N. Predictors of unsuccessful tuberculosis treatment outcomes in Brazil: an analysis of 259,484 patient records. BMC Infectious Diseases 2024, 24: 531. PMID: 38802744, PMCID: PMC11129366, DOI: 10.1186/s12879-024-09417-7.Peer-Reviewed Original ResearchConceptsTreatment outcomesFactors associated with unsuccessful treatment outcomesHigher risk of poor treatment outcomeTB treatmentRisk of poor treatment outcomesUnsuccessful treatmentEffectiveness of TB treatmentAssociated with unsuccessful treatmentUnsuccessful treatment outcomesTuberculosis treatment outcomesDrug-susceptible TBHealth system levelMultivariate logistic regression modelService-related factorsTB drug resistanceComorbid health conditionsHealth-related behaviorsCategorizing treatment outcomesPatient-level factorsClinical examination resultsNational Disease Notification SystemPoor treatment outcomesDisease notification systemHIV infectionLogistic regression models
2014
Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts
Huang CC, Tchetgen ET, Becerra MC, Cohen T, Galea J, Calderon R, Yataco R, Contreras C, Zhang ZB, Lecca L, Murray M. Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts. The International Journal Of Tuberculosis And Lung Disease 2014, 18: 1285-1291. PMID: 25299859, DOI: 10.5588/ijtld.14.0309.Peer-Reviewed Original ResearchConceptsLatent tuberculous infectionTuberculin skin testTB patientsIndex caseChild household contactsDrug-susceptible TBIndex TB patientsObservational cohort studySecondhand smoke exposureRisk of transmissionPoisson regression modelsHousehold contactsCohort studyTST positivityTuberculosis patientsTuberculous infectionSmoke exposureSmoking statusTuberculosis casesCigarette smokingSkin testRisk factorsPatientsInfection statusTime pointsDrivers and Trajectories of Resistance to New First-Line Drug Regimens for Tuberculosis
Shrestha S, Knight GM, Fofana M, Cohen T, White RG, Cobelens F, Dowdy DW. Drivers and Trajectories of Resistance to New First-Line Drug Regimens for Tuberculosis. Open Forum Infectious Diseases 2014, 1: ofu073. PMID: 25734143, PMCID: PMC4281792, DOI: 10.1093/ofid/ofu073.Peer-Reviewed Original ResearchDrug-resistant TBTreatment of tuberculosisNew drug regimenTransmission fitnessDrug regimensDrug regimenTreatment successDrug-susceptible TBAppropriate second-line therapyDR-TB prevalenceSecond-line therapyDrug resistance trendsTreatment success rateHigher treatment successNovel drug regimensEmergence of resistancePopulation-level dataTB regimensShort-term surveillanceDS-TBNew regimenClinical trialsEarly diagnosisRegimensDrug resistance