2001
Thrombospondin‐2 plays a protective role in multistep carcinogenesis: a novel host anti‐tumor defense mechanism
Hawighorst T, Velasco P, Streit M, Hong Y, Kyriakides T, Brown L, Bornstein P, Detmar M. Thrombospondin‐2 plays a protective role in multistep carcinogenesis: a novel host anti‐tumor defense mechanism. The EMBO Journal 2001, 20: 2631-2640. PMID: 11387198, PMCID: PMC125494, DOI: 10.1093/emboj/20.11.2631.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsApoptosisCell Adhesion MoleculesCell DivisionDisease SusceptibilityEndothelial Growth FactorsFemaleGene Expression Regulation, NeoplasticLymphokinesMiceMice, Inbred StrainsMice, KnockoutNeovascularization, PathologicOligodeoxyribonucleotides, AntisensePapillomaPrecancerous ConditionsSkinSkin NeoplasmsThrombospondinsTime FactorsTranscription, GeneticVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsWild-type miceTSP-2 expressionThrombospondin-2Angiogenic switchTumor formationMultistep carcinogenesisVascular endothelial growth factorAnti-angiogenic factorsTSP-2-deficient miceEndothelial growth factorAngiogenesis inhibitor thrombospondin-2Endogenous angiogenesis inhibitorTumor cell apoptosisTumor differentiationMesenchymal stromaMulti-step tumorigenesisDefense mechanismsAngiogenesis inhibitorsProtective roleAngiogenesis factorsTumor angiogenesisTumor cellsGrowth factorCell apoptosis
2000
Increased Marrow‐Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2*
Hankenson K, Bain S, Kyriakides T, Smith E, Goldstein S, Bornstein P. Increased Marrow‐Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2*. Journal Of Bone And Mineral Research 2000, 15: 851-862. PMID: 10804014, DOI: 10.1359/jbmr.2000.15.5.851.Peer-Reviewed Original ResearchConceptsBone formation rateEndosteal bone formation rateEndosteal bone formationTSP2-null miceMarrow stromal cellsComputerized tomographyThrombospondin-2Bone formationNormal bone resorptionWild-type animalsOvariectomized miceBone lossCortical densityRate of proliferationBone resorptionLigamentous laxityBone massVascular densityHistomorphometric analysisNull miceMutant miceStromal cellsMiceLong bonesCellular basis
1995
Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo
Hugo C, Pichler R, Meek R, Gordon K, Kyriakides T, Floege J, Bornstein P, Couser W, Johnson R. Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo. Kidney International 1995, 48: 1846-1856. PMID: 8587244, DOI: 10.1038/ki.1995.483.Peer-Reviewed Original ResearchConceptsAnti-Thy1 antibodyMesangial cell proliferationThrombospondin-1 expressionMesangial cellsThrombospondin-1Anti-Thy1 nephritisCell proliferationAnti-bFGF antibodyExperimental mesangial proliferative nephritisDe novo expressionMesangial proliferative nephritisGlomerular diseaseNormal ratsProliferative nephritisThrombospondin-1 mRNANovo expressionDouble labelingRatsPDGFAntibodiesNephritisBFGFInfusionDiseaseVivo