2019
Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes
Kunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR. Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes. Diabetes 2019, 68: 2016-2023. PMID: 31391172, PMCID: PMC6754242, DOI: 10.2337/db18-1001.Peer-Reviewed Original ResearchConceptsThrombospondin-2TSP2 expressionDiabetic control miceWound healingEffects of hyperglycemiaImpaired wound healingUnderlying pathological mechanismsDelayed Wound HealingMajor cellular sourceBlood vessel maturationGranulation tissue formationMajor complicationsDiabetic miceControl miceTreatment strategiesDiabetesPathological mechanismsDiabetic woundsAccelerated reepithelializationCellular sourceHigh glucoseHyperglycemiaMatricellular proteinExpression contributesHexosamine pathway
2001
Thrombospondin‐2 plays a protective role in multistep carcinogenesis: a novel host anti‐tumor defense mechanism
Hawighorst T, Velasco P, Streit M, Hong Y, Kyriakides T, Brown L, Bornstein P, Detmar M. Thrombospondin‐2 plays a protective role in multistep carcinogenesis: a novel host anti‐tumor defense mechanism. The EMBO Journal 2001, 20: 2631-2640. PMID: 11387198, PMCID: PMC125494, DOI: 10.1093/emboj/20.11.2631.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsApoptosisCell Adhesion MoleculesCell DivisionDisease SusceptibilityEndothelial Growth FactorsFemaleGene Expression Regulation, NeoplasticLymphokinesMiceMice, Inbred StrainsMice, KnockoutNeovascularization, PathologicOligodeoxyribonucleotides, AntisensePapillomaPrecancerous ConditionsSkinSkin NeoplasmsThrombospondinsTime FactorsTranscription, GeneticVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsWild-type miceTSP-2 expressionThrombospondin-2Angiogenic switchTumor formationMultistep carcinogenesisVascular endothelial growth factorAnti-angiogenic factorsTSP-2-deficient miceEndothelial growth factorAngiogenesis inhibitor thrombospondin-2Endogenous angiogenesis inhibitorTumor cell apoptosisTumor differentiationMesenchymal stromaMulti-step tumorigenesisDefense mechanismsAngiogenesis inhibitorsProtective roleAngiogenesis factorsTumor angiogenesisTumor cellsGrowth factorCell apoptosis
2000
Thrombospondin 2 Modulates Collagen Fibrillogenesis and Angiogenesis
Bornstein P, Kyriakides T, Yang Z, Armstrong L, Birk D. Thrombospondin 2 Modulates Collagen Fibrillogenesis and Angiogenesis. Journal Of Investigative Dermatology Symposium Proceedings 2000, 5: 61-66. PMID: 11147677, DOI: 10.1046/j.1087-0024.2000.00005.x.Peer-Reviewed Original ResearchConceptsVascular densityTSP2-null miceMatrix metalloproteinase-2 productionMetalloproteinase-2 productionConnective tissue abnormalitiesFlexor muscle tendonsExcisional skin woundsPolyvinyl alcohol spongesSilicone rubber discsAbnormal collagen fibrilsMuscle tendonSubcutaneous tissueNull miceTissue abnormalitiesDistinct abnormalitiesEndothelial cellsThrombospondin-2Matricellular proteinAlcohol spongesTHBS2 geneCell functionCell-matrix interactionsMiceSkin woundsMode of actionMatricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2
Yang Z, Kyriakides T, Bornstein P. Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2. Molecular Biology Of The Cell 2000, 11: 3353-3364. PMID: 11029041, PMCID: PMC14997, DOI: 10.1091/mbc.11.10.3353.Peer-Reviewed Original ResearchConceptsCell-matrix interactionsAbnormal cell-matrix interactionsWild-type cellsTSP2-null miceAdhesive defectsComplex phenotypesCell spreadingMolecular mechanismsMutant fibroblastsProtein resultsMatrix proteinsStable transfectionMatrix metalloproteinasesMetalloproteinase-2Matricellular proteinAltered expressionTHBS2 geneNull miceAffinity chromatographyGelatinolytic assaysThrombospondin-2TSP2Matrix metalloproteinase-2FibroblastsLevels of MMP2
1999
Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity
Kyriakides T, Leach K, Hoffman A, Ratner B, Bornstein P. Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 4449-4454. PMID: 10200282, PMCID: PMC16352, DOI: 10.1073/pnas.96.8.4449.Peer-Reviewed Original Research
1998
The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice
Kyriakides T, Zhu Y, Yang Z, Bornstein P. The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice. Journal Of Histochemistry & Cytochemistry 1998, 46: 1007-1015. PMID: 9705966, DOI: 10.1177/002215549804600904.Peer-Reviewed Original ResearchConceptsCell-matrix interactionsMatricellular protein thrombospondin-2Adult tissuesThrombospondin-2TSP2-null micePleiotropic phenotypesTissue-forming cellsCell movementEmbryonic developmentDermal fibroblastsPericellular environmentAdhesion defectsDay 15Connective tissueLeidig cellsTissue repairDay 18 embryosDermal cellsCells