Increased Marrow‐Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2*
Hankenson K, Bain S, Kyriakides T, Smith E, Goldstein S, Bornstein P. Increased Marrow‐Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2*. Journal Of Bone And Mineral Research 2000, 15: 851-862. PMID: 10804014, DOI: 10.1359/jbmr.2000.15.5.851.Peer-Reviewed Original ResearchConceptsBone formation rateEndosteal bone formation rateEndosteal bone formationTSP2-null miceMarrow stromal cellsComputerized tomographyThrombospondin-2Bone formationNormal bone resorptionWild-type animalsOvariectomized miceBone lossCortical densityRate of proliferationBone resorptionLigamentous laxityBone massVascular densityHistomorphometric analysisNull miceMutant miceStromal cellsMiceLong bonesCellular basis