2024
Bone-derived extracellular matrix hydrogel from thrombospondin-2 knock-out mice for bone repair
Chen Z, Zhang J, Lee F, Kyriakides T. Bone-derived extracellular matrix hydrogel from thrombospondin-2 knock-out mice for bone repair. Acta Biomaterialia 2024, 186: 85-94. PMID: 39134130, PMCID: PMC11500023, DOI: 10.1016/j.actbio.2024.08.011.Peer-Reviewed Original ResearchECM hydrogelsWild typeBone repairLack of mechanical integrityExtracellular matrixRepair of bone defectsExtracellular matrix hydrogelDecellularized extracellular matrixMurine calvarial defect modelCalvarial defect modelPromote bone repairHuman umbilical vein endothelial cellsMesenchymal stem cellsThrombospondin-2Fabricated hydrogelsBone extracellular matrixNovel hydrogelsMechanical propertiesCollagen fibril assemblyMatrix hydrogelRepair damaged boneDecellularized ECMMechanical integrityHydrogelsInvasion in vitro
2018
Tunable Hydrogels Derived from Genetically Engineered Extracellular Matrix Accelerate Diabetic Wound Healing
Morris AH, Lee H, Xing H, Stamer DK, Tan M, Kyriakides TR. Tunable Hydrogels Derived from Genetically Engineered Extracellular Matrix Accelerate Diabetic Wound Healing. ACS Applied Materials & Interfaces 2018, 10: 41892-41901. PMID: 30424595, PMCID: PMC9996546, DOI: 10.1021/acsami.8b08920.Peer-Reviewed Original ResearchHierarchical Micro- and Nanopatterning of Metallic Glass to Engineer Cellular Responses
Wang J, Loye A, Ketkaew J, Schroers J, Kyriakides T. Hierarchical Micro- and Nanopatterning of Metallic Glass to Engineer Cellular Responses. ACS Applied Bio Materials 2018, 1: 51-58. DOI: 10.1021/acsabm.8b00007.Peer-Reviewed Original ResearchHierarchical microNano/micro levelTopographical length scalesLength scalesMechanical propertiesMultiple length scalesPt-BMGMetallic glassesWetting abilityRelevant length scalesForeign body responseNanotopographical featuresCellular responsesAmorphous natureEngineering sciencesSpecific cell responsesMicroSubstrateCell behaviorCell typesMorphology of macrophagesMacrophage fusionCell morphologyNanopatterningBiomaterials
2017
Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix
Kristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR. Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix. Biomaterials 2017, 141: 63-73. PMID: 28667900, PMCID: PMC5918415, DOI: 10.1016/j.biomaterials.2017.06.025.Peer-Reviewed Original ResearchConceptsUnmodified graftsVascular graftsCoronary bypass proceduresMechanical propertiesMural cell recruitmentBypass proceduresRat aortaMMP levelsCell recruitmentDecreased failure rateGraftPlatelet studiesGraft mechanical propertiesNative vesselsShelf vascular graftsSmall-diameter vascular graftsTime pointsExtracellular matrixDiameter vascular graftsTensile strengthYoung's modulusWT cellsPresent studySuture retentionFailure rate