2016
Nanoparticle delivery of miR-223 to attenuate macrophage fusion
Moore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR. Nanoparticle delivery of miR-223 to attenuate macrophage fusion. Biomaterials 2016, 89: 127-135. PMID: 26967647, PMCID: PMC4924476, DOI: 10.1016/j.biomaterials.2016.02.036.Peer-Reviewed Original ResearchConceptsForeign body giant cellsMiR-223 mimicsMiR-223Foreign body responseMacrophage fusionSubsequent cytoskeletal rearrangementMiR microarrayKO miceRole of microRNAsMolecular mediatorsNegative regulatorGiant cellsPrimary macrophagesFusion of macrophagesNovel mediatorPrecise mechanismFusion-competent stateTherapeutic inhibitorsBody responseMacrophagesNanoparticle deliveryImplant modelMediatorsEventual encapsulationPost-transcriptional level
2015
Chapter 5 Molecular Events at Tissue–Biomaterial Interface
Kyriakides T. Chapter 5 Molecular Events at Tissue–Biomaterial Interface. 2015, 81-116. DOI: 10.1016/b978-0-12-800196-7.00005-0.Peer-Reviewed Original ResearchMolecular eventsIntracellular molecular pathwaysInteraction of proteinsKey inflammatory cell typeProduction of signalsAssociated proteinsProtein altersAltered conformationTissue-biomaterial interfaceConformational changesCell adhesionMolecular pathwaysCell typesProteinProteinaceous coatingsCell functionMolecular interactionsCell receptorCurrent understandingBiomaterial interactionsMatrix depositionActivationEventual encapsulationResident cellsCells