2018
Hierarchical Micro- and Nanopatterning of Metallic Glass to Engineer Cellular Responses
Wang J, Loye A, Ketkaew J, Schroers J, Kyriakides T. Hierarchical Micro- and Nanopatterning of Metallic Glass to Engineer Cellular Responses. ACS Applied Bio Materials 2018, 1: 51-58. DOI: 10.1021/acsabm.8b00007.Peer-Reviewed Original ResearchHierarchical microNano/micro levelTopographical length scalesLength scalesMechanical propertiesMultiple length scalesPt-BMGMetallic glassesWetting abilityRelevant length scalesForeign body responseNanotopographical featuresCellular responsesAmorphous natureEngineering sciencesSpecific cell responsesMicroSubstrateCell behaviorCell typesMorphology of macrophagesMacrophage fusionCell morphologyNanopatterningBiomaterialsDecellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds
Morris AH, Stamer DK, Kunkemoeller B, Chang J, Xing H, Kyriakides TR. Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds. Biomaterials 2018, 169: 61-71. PMID: 29631168, PMCID: PMC5933884, DOI: 10.1016/j.biomaterials.2018.03.049.Peer-Reviewed Original ResearchConceptsUltimate tensile strengthECM-based materialsTensile strengthMechanical testingDecellularized materialsElastic modulusSynthetic biomaterialsIntact slabsMatrix propertiesExtracellular matrix propertiesCell-derived ECMBiologic scaffoldsElectron microscopyEngineering controlsMaterialsWtEfficient integrationEnhanced vascularizationModulusPromigratory propertiesScaffoldsPropertiesBiomaterialsEnhanced remodelingGreater cell migration
2017
The host response to naturally-derived extracellular matrix biomaterials
Morris AH, Stamer DK, Kyriakides TR. The host response to naturally-derived extracellular matrix biomaterials. Seminars In Immunology 2017, 29: 72-91. PMID: 28274693, DOI: 10.1016/j.smim.2017.01.002.Peer-Reviewed Original Research
2009
Bulk metallic glasses for biomedical applications
Schroers J, Kumar G, Hodges T, Chan S, Kyriakides T. Bulk metallic glasses for biomedical applications. JOM 2009, 61: 21-29. DOI: 10.1007/s11837-009-0128-1.Peer-Reviewed Original ResearchBulk metallic glassMetallic glassesBiomedical applicationsField of biomaterialsMetallic biomaterialsImplant applicationsExcellent combinationMaterial propertiesSuperior propertiesComplex implantsSurface topographyDesirable biological responsesForeign body responseBiomaterialsProcessing capabilitiesFlexible chemistryGlassPropertiesAtomic structureApplicationsBiocompatibilityBody responseDevicesMaterials