2019
Semiautomated Measure of Abdominal Adiposity Using Computed Tomography Scan Analysis
Srikumar T, Siegel E, Gu Y, Balagurunathan Y, Garcia A, Chen Y, Zhou J, Zhao X, Gillies R, Clark W, Gamenthaler A, Choi J, Shibata D. Semiautomated Measure of Abdominal Adiposity Using Computed Tomography Scan Analysis. Journal Of Surgical Research 2019, 237: 12-21. PMID: 30694786, PMCID: PMC7771581, DOI: 10.1016/j.jss.2018.11.027.Peer-Reviewed Original ResearchConceptsVisceral fat areaSubcutaneous fat areaTotal fat areaFat areaTomography scan analysisAbdominal adiposityIntraclass correlationL4-L5 intervertebral levelAverage body mass indexSubcutaneous fat ratioBody mass indexMedian ageRectal adenocarcinomaRisk stratificationMass indexIntervertebral levelObesity epidemicRadiologic methodsAdipose tissueSemiautomated measureAdiposityFat ratioHuman pathophysiologyImaging suiteSemiautomated method
2017
Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes
Ozoya O, Siegel E, Srikumar T, Bloomer A, DeRenzis A, Shibata D. Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes. Journal Of Gastrointestinal Surgery 2017, 21: 534-542. PMID: 28101721, PMCID: PMC5560865, DOI: 10.1007/s11605-017-3362-9.Peer-Reviewed Original ResearchConceptsBody mass indexVisceral obesityPostoperative morbidityObese patientsShort-term postoperative outcomesOverall complication rateColon cancer outcomesMeasures of adiposityColon cancer patientsMetabolic comorbiditiesPostoperative complicationsComplication ratePostoperative outcomesVisceral adipositySurgical morbidityMass indexRisk stratificationRetrospective studyCancer outcomesCancer patientsTomography assessmentPreoperative CTMortality rateStage IColon cancerAspergillus Terreus Brain Abscess Complicated by Tension Pneumocephalus in a Patient with Angiosarcoma
Srikumar T, Pabbathi S, Fernandez J, Nanjappa S. Aspergillus Terreus Brain Abscess Complicated by Tension Pneumocephalus in a Patient with Angiosarcoma. American Journal Of Case Reports 2017, 18: 33-37. PMID: 28070116, PMCID: PMC5240880, DOI: 10.12659/ajcr.900425.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Bacterial AgentsAspergillosisAspergillusBacteremiaBrain AbscessCefepimeCephalosporinsDisease ProgressionDrug CombinationsDrug Therapy, CombinationGlucocorticoidsHemangiosarcomaHumansImmunocompromised HostMagnetic Resonance ImagingMalePneumocephalusProteus mirabilisSkin NeoplasmsStaphylococcus aureusSulfamethizoleTomography, X-Ray ComputedTreatment OutcomeTrimethoprimVancomycinVoriconazoleConceptsTension pneumocephalusComputed tomographyRight frontal lobe abscessCultures of lesionsFrontal lobe abscessLeft arm strengthLow-grade feverProteus mirabilis bacteremiaTrimethroprim/sulfamethoxazoleContinuous supplemental oxygenSystemic antifungal agentsSerial X-raysUpper extremity strengthIntravenous vancomycinRecurrent angiosarcomaBrain abscessesConservative managementEmergent evaluationPrompt diagnosisScalp angiosarcomaSupplemental oxygenIntracranial abscessPoor outcomeCase reportMental status
2016
Potential Use of Flavopiridol in Treatment of Chronic Diseases
Srikumar T, Padmanabhan J. Potential Use of Flavopiridol in Treatment of Chronic Diseases. Advances In Experimental Medicine And Biology 2016, 929: 209-228. PMID: 27771926, DOI: 10.1007/978-3-319-41342-6_9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicAntiviral AgentsApoptosisCardiovascular AgentsCell Cycle CheckpointsCell ProliferationChronic DiseaseDisease Models, AnimalDrug DiscoveryFlavonoidsHumansMolecular StructurePhytotherapyPiperidinesPlants, MedicinalSignal TransductionConceptsChronic diseasesElicit anti-inflammatory activityAberrant cell cycle activationNFκB-dependent signalingEffect of flavopiridolAnti-inflammatory activityArrests cell cycle progressionCell cycle activationInflammatory stimuliAnti-apoptotic genesAnti-proliferative activityCell cycle progressionDiseaseInhibits expressionCycle activationFlavopiridolCycle progressionCDK inhibitorsPotential useGrowth-arrested cellsRecent studiesRNA polymerase II activationTreatmentP-TEFb complexActivationIncreased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers
Kothari N, Teer J, Abbott A, Srikumar T, Zhang Y, Yoder S, Brohl A, Kim R, Reed D, Shibata D. Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. Cancer 2016, 122: 2828-2835. PMID: 27244218, PMCID: PMC5014625, DOI: 10.1002/cncr.30082.Peer-Reviewed Original ResearchConceptsColorectal cancerYounger patientsExome sequencingOutcomes of patientsSporadic colorectal cancerUnique genetic alterationsFisher's exact testCRC data setsWhole-exome sequencingWorse survivalRetrospective studyTreatment modalitiesBRAF mutationsPatientsExact testFBXW7 geneLarger studyOlder agePatient samplesCohortFinal analysisSporadic cancersStatistical significanceGenetic alterationsFuture screeningPortal Hypertension Over the Last 25 Years: Where Did It Go?
Rosemurgy A, Raitano O, Srikumar T, Sawangkum P, Luberice K, Ryan C, Ross S. Portal Hypertension Over the Last 25 Years: Where Did It Go? Journal Of The American College Of Surgeons 2016, 222: 1164-1170. PMID: 27234633, DOI: 10.1016/j.jamcollsurg.2016.02.017.Peer-Reviewed Original ResearchConceptsPercentage of patientsPortal hypertensionDecompressive shuntsHospital mortalityEndoscopic therapyEndoscopic treatmentNumber of patientsEsophageal varicesHealth care administrationHospital inpatientsHypertensionPatientsShuntDiagnosisCare administrationVaricesSurgeryTherapyMortalityTreatmentAdmissionInpatientsYearsSurgeonsAdministration