Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers
Kothari N, Teer J, Abbott A, Srikumar T, Zhang Y, Yoder S, Brohl A, Kim R, Reed D, Shibata D. Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. Cancer 2016, 122: 2828-2835. PMID: 27244218, PMCID: PMC5014625, DOI: 10.1002/cncr.30082.Peer-Reviewed Original ResearchConceptsColorectal cancerYounger patientsExome sequencingOutcomes of patientsSporadic colorectal cancerUnique genetic alterationsFisher's exact testCRC data setsWhole-exome sequencingWorse survivalRetrospective studyTreatment modalitiesBRAF mutationsPatientsExact testFBXW7 geneLarger studyOlder agePatient samplesCohortFinal analysisSporadic cancersStatistical significanceGenetic alterationsFuture screening