Chronic lymphocytic leukemia: prognostic factors and impact on treatment.
Parker TL, Strout MP. Chronic lymphocytic leukemia: prognostic factors and impact on treatment. Discovery Medicine 2011, 11: 115-23. PMID: 21356166.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorHumansImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionLeukemia, Lymphocytic, Chronic, B-CellMicroRNAsPrognosisConceptsChronic lymphocytic leukemiaPrognostic markerBiology of CLLClinical staging systemStandard chemotherapy regimensObvious survival advantageSymptomatic leukemiaChemotherapy regimensMature B cellsPrognostic factorsProlong survivalIndolent diseaseStaging systemClinical managementImmediate treatmentDisease progressionEarly treatmentLymphocytic leukemiaSurvival advantageAggressive formB cellsClinical heterogeneityClonal malignancyEarly interventionPatients