2012
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice
Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology 2012, 225: 217-226. PMID: 22842765, PMCID: PMC3552490, DOI: 10.1007/s00213-012-2809-7.Peer-Reviewed Original ResearchConceptsChronic clozapineLysergic acid diethylamideAtypical antipsychotic drug actionHead-twitch behaviorC-fosAntipsychotic-like activityAntipsychotic drug actionTherapeutic-like effectsMouse somatosensory cortexSchizophrenia-like behavioral alterationsEgr-2Egr-1Chronic haloperidolChronic treatmentClozapine administrationDrug therapyOptimal treatmentSomatosensory cortexSingle administrationAntipsychotic drugsMurine modelMouse modelRodent modelsSerotonin 5Behavioral alterations
2011
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors
Albizu L, Holloway T, González-Maeso J, Sealfon SC. Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology 2011, 61: 770-777. PMID: 21645528, PMCID: PMC3556730, DOI: 10.1016/j.neuropharm.2011.05.023.Peer-Reviewed Original ResearchConceptsMK-801-induced locomotor activityAlteration of serotoninDopamine D2 receptorsG protein-coupled receptor targetsFunctional crosstalkHEK293 cellsAntipsychotic effectsAntipsychotic drugsD2 receptorsSerotonin 5Dopamine systemLocomotor activityRadioligand bindingAgonist affinityReceptor targetsTherapeutic drugsReceptorsProduction assaysCo-immunoprecipitation studiesSerotoninReceptor heterocomplexDrugsActivationCellsAntagonistMetabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neuroscience Letters 2011, 493: 76-79. PMID: 21276828, PMCID: PMC3064746, DOI: 10.1016/j.neulet.2011.01.046.Peer-Reviewed Original ResearchConceptsLysergic acid diethylamideHallucinogen DOIBehavioral effectsHead-twitch behaviorC-fosEgr-2Hallucinogenic 5MGlu2 receptorReceptor agonistKnockout miceHigh-affinity binding sitesNeuropsychological responsesMiceAgonistsAcid diethylamideHallucinogenic drugsSignaling pathwaysCellular signaling pathwaysReceptorsFunctional interactionMembrane preparationsBehavioral responsesResponseWild typeSerotonin