Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors
Intihar TA, Martinez EA, Gomez-Pastor R. Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors. Frontiers In Cellular Neuroscience 2019, 13: 103. PMID: 30941017, PMCID: PMC6433789, DOI: 10.3389/fncel.2019.00103.Peer-Reviewed Original ResearchMutant HttTranscription factorsMitochondrial dysfunctionPGC-1αMitochondrial functionCo-activator PGC-1αTranscription factor HSF1Main transcription factorHuntington's diseaseProtein homeostasisHSF1Medium spiny neuronsP53 levelsUnifying mechanismHuntingtin geneNeurodegenerative diseasesP53ProteinPotential roleStriatal medium spiny neuronsCAG repeatsThird mechanismMisfoldHD progressionGenes