2023
Correlation of a commercial platform’s results with post-vaccination SARS-CoV-2 neutralizing antibody response and clinical host factors
Slotkin R, Kyriakides T, Kundu A, Stack G, Sutton R, Gupta S. Correlation of a commercial platform’s results with post-vaccination SARS-CoV-2 neutralizing antibody response and clinical host factors. PLOS ONE 2023, 18: e0289713. PMID: 37643190, PMCID: PMC10464955, DOI: 10.1371/journal.pone.0289713.Peer-Reviewed Original ResearchAnalysis of Repair Type and Hypogastric Artery Antegrade Perfusion and Erectile Function following Repair of Abdominal Aortic Aneurysms
Bennett K, Hurley L, Kyriakides T, Matsumura J, Group O. Analysis of Repair Type and Hypogastric Artery Antegrade Perfusion and Erectile Function following Repair of Abdominal Aortic Aneurysms. Annals Of Vascular Surgery 2023, 94: 186-194. PMID: 37164171, DOI: 10.1016/j.avsg.2023.04.025.Peer-Reviewed Original ResearchConceptsErectile functionArtery perfusionErectile dysfunctionHypogastric flowEndovascular repairAneurysm repairAortic aneurysmAntegrade perfusionPreoperative ankle-brachial indexErectile Function-5 (IIEF-5) questionnaireAbdominal aortic aneurysm repairHypogastric artery exclusionSignificant erectile dysfunctionThoracic aortic proceduresAnkle-brachial indexBeta-blocker useFifth of patientsSpinal cord ischemiaAortic aneurysm repairAbdominal aortic aneurysmMixed effects regression modelsBranched deviceButtock claudicationEndovascular groupBlocker use
2022
Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population
Zhao M, Slotkin R, Sheth AH, Pischel L, Kyriakides TC, Emu B, McNamara C, Shi Q, Delgobbo J, Xu J, Marhoffer E, Mercer-Falkoff A, Holleck J, Ardito D, Sutton RE, Gupta S. Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population. Clinical Infectious Diseases 2022, 76: e391-e399. PMID: 35639598, PMCID: PMC9278145, DOI: 10.1093/cid/ciac416.Peer-Reviewed Original ResearchConceptsMonth postboosterRNA vaccinationClinical variablesNeutralization responseEnd-stage renal diseaseBooster dose responsePrimary series vaccinationPrimary vaccine seriesMultiple clinical factorsSystemic steroid useDoses of vaccinePrior COVID-19Maximal inhibitory concentration valuesHalf maximal inhibitory concentration (IC50) valuesSeries vaccinationVaccine seriesVaccine regimensClinical factorsDiabetes mellitusRenal diseaseComorbid conditionsSteroid useCOVID infectionImmune responseUS population
2019
Open versus Endovascular Repair of Abdominal Aortic Aneurysm
Lederle FA, Kyriakides TC, Stroupe KT, Freischlag JA, Padberg FT, Matsumura JS, Huo Z, Johnson GR. Open versus Endovascular Repair of Abdominal Aortic Aneurysm. New England Journal Of Medicine 2019, 380: 2126-2135. PMID: 31141634, DOI: 10.1056/nejmoa1715955.Peer-Reviewed Original ResearchConceptsEndovascular repair groupOpen repair groupEndovascular repairOpen repairOverall survivalAbdominal aortic aneurysmEuropean trialsAortic aneurysmLong-term overall survivalChronic obstructive lung diseaseWorse long-term outcomesAsymptomatic abdominal aortic aneurysmElective endovascular repairLow perioperative mortalityObstructive lung diseaseTraditional open repairAbdominal aortic aneurysms resultsLong-term outcomesLong-term resultsNumber of patientsLong-term survivalCause mortalityPerioperative mortalityPerioperative periodMore patients
2017
Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years
Powell J, Sweeting M, Ulug P, Blankensteijn J, Lederle F, Becquemin J, Greenhalgh R, , Greenhalgh R, Beard J, Buxton M, Brown L, Harris P, Powell J, Rose J, Russell I, Sculpher M, Thompson S, Lilford R, Bell P, Greenhalgh R, Whitaker S, Poole‐Wilson T, Ruckley C, Campbell W, Dean M, Ruttley M, Coles E, Powell J, Halliday A, Gibbs S, Brown L, Epstein D, Sculpher M, Thompson S, Hannon R, Johnston L, Bradbury A, Henderson M, Parvin S, Shepherd D, Greenhalgh R, Mitchell A, Edwards P, Abbott G, Higman D, Vohra A, Ashley S, Robottom C, Wyatt M, Rose J, Byrne D, Edwards R, Leiberman D, McCarter D, Taylor P, Reidy J, Wilkinson A, Ettles D, Clason A, Leen G, Wilson N, Downes M, Walker S, Lavelle J, Gough M, McPherson S, Scott D, Kessell D, Naylor R, Sayers R, Fishwick N, Harris P, Gould D, Walker M, Chalmers N, Garnham A, Collins M, Beard J, Gaines P, Ashour M, Uberoi R, Braithwaite B, Whitaker S, Davies J, Travis S, Hamilton G, Platts A, Shandall A, Sullivan B, Sobeh M, Matson M, Fox A, Orme R, Yusef W, Doyle T, Horrocks M, Hardman J, Blair P, Ellis P, Morris G, Odurny A, Vohra R, Duddy M, Thompson M, Loosemore T, Belli A, Morgan R, Adiseshiah M, Brookes J, McCollum C, Ashleigh R, Aukett M, Baker S, Barbe E, Batson N, Bell J, Blundell J, Boardley D, Boyes S, Brown O, Bryce J, Carmichael M, Chance T, Coleman J, Cosgrove C, Curran G, Dennison T, Devine C, Dewhirst N, Errington B, Farrell H, Fisher C, Fulford P, Gough M, Graham C, Hooper R, Horne G, Horrocks L, Hughes B, Hutchings T, Ireland M, Judge C, Kelly L, Kemp J, Kite A, Kivela M, Lapworth M, Lee C, Linekar L, Mahmood A, March L, Martin J, Matharu N, McGuigen K, Morris‐Vincent P, Murray S, Murtagh A, Owen G, Ramoutar V, Rippin C, Rowley J, Sinclair J, Spencer S, Taylor V, Tomlinson C, Ward S, Wealleans V, West J, White K, Williams J, Wilson L, Grobbee D, Blankensteijn J, Bak A, Buth J, Pattynama P, Verhoeven E, van Voorthuisen A, Blankensteijn J, Balm R, Buth J, Cuypers P, Grobbee D, Prinssen M, van Sambeek M, Verhoeven E, Baas A, Hunink M, van Engelshoven J, Jacobs M, de Mol B, van Bockel J, Balm R, Reekers J, Tielbeek X, Verhoeven E, Wisselink W, Boekema N, Heuveling L, Sikking I, Prinssen M, Balm R, Blankensteijn J, Buth J, Cuypers P, van Sambeek M, Verhoeven E, de Bruin J, Baas A, Blankensteijn J, Prinssen M, Buth J, Tielbeek A, Blankensteijn J, Balm R, Reekers J, van Sambeek M, Pattynama P, Verhoeven E, Prins T, van der Ham A, van der Velden J, van Sterkenburg S, ten Haken G, Bruijninckx C, van Overhagen H, Tutein Nolthenius R, Hendriksz T, Teijink J, Odink H, de Smet A, Vroegindeweij D, van Loenhout R, Rutten M, Hamming J, Lampmann L, Bender M, Pasmans H, Vahl A, de Vries C, Mackaay A, van Dortmont L, van der Vliet A, Schultze Kool L, Boomsma J, van Dop H, de Mol van Otterloo J, de Rooij T, Smits T, Yilmaz E, Wisselink W, van den Berg F, Visser M, van der Linden E, Schurink G, de Haan M, Smeets H, Stabel P, van Elst F, Poniewierski J, Vermassen F, Lederle F, Freischlag J, Kohler T, Latts E, Matsumura J, Padberg F, Kyriakides T, Swanson K, Guarino P, Peduzzi P, Antonelli M, Cushing C, Davis E, Durant L, Joyner S, Kossack T, Kyriakides T, LeGwin M, McBride V, O'Connor T, Poulton J, Stratton T, Zellner S, Snodgrass A, Thornton J, Swanson K, Haakenson C, Stroupe K, Jonk Y, Hallett J, Hertzer N, Towne J, Katz D, Karrison T, Matts J, Marottoli R, Kasl S, Mehta R, Feldman R, Farrell W, Allore H, Perry E, Niederman J, Randall F, Zeman M, Beckwith T, O'Leary T, Huang G, Latts E, Bader M, Ketteler E, Kingsley D, Marek J, Massen R, Matteson B, Pitcher J, Langsfeld M, Corson J, Goff J, Kasirajan K, Paap C, Robertson D, Salam A, Veeraswamy R, Milner R, Kasirajan K, Guidot J, Lal B, Busuttil S, Lilly M, Braganza M, Ellis K, Patterson M, Jordan W, Whitley D, Taylor S, Passman M, Kerns D, Inman C, Poirier J, Ebaugh J, Raffetto J, Chew D, Lathi S, Owens C, Hickson K, Dosluoglu H, Eschberger K, Kibbe M, Baraniewski H, Matsumura J, Endo M, Busman A, Meadows W, Evans M, Giglia J, El Sayed H, Reed A, Ruf M, Ross S, Jean‐Claude J, Pinault G, Kang P, White N, Eiseman M, Jones T, Timaran C, Modrall J, Welborn M, Lopez J, Nguyen T, Chacko J, Granke K, Vouyouka A, Olgren E, Chand P, Allende B, Ranella M, Yales C, Whitehill T, Krupski T, Nehler M, Johnson S, Jones D, Strecker P, Bhola M, Shortell C, Gray J, Lawson J, McCann R, Sebastian M, Kistler Tetterton J, Blackwell C, Prinzo P, Lee N, Padberg F, Cerveira J, Lal B, Zickler R, Hauck K, Berceli S, Lee W, Ozaki C, Nelson P, Irwin A, Baum R, Aulivola B, Rodriguez H, Littooy F, Greisler H, O'Sullivan M, Kougias P, Lin P, Bush R, Guinn G, Bechara C, Cagiannos C, Pisimisis G, Barshes N, Pillack S, Guillory B, Cikrit D, Lalka S, Lemmon G, Nachreiner R, Rusomaroff M, O'Brien E, Cullen J, Hoballah J, Sharp W, McCandless J, Beach V, Minion D, Schwarcz T, Kimbrough J, Ashe L, Rockich A, Warner‐Carpenter J, Moursi M, Eidt J, Brock S, Bianchi C, Bishop V, Gordon I, Fujitani R, Kubaska S, Behdad M, Azadegan R, Ma Agas C, Zalecki K, Hoch J, Carr S, Acher C, Schwarze M, Tefera G, Mell M, Dunlap B, Rieder J, Stuart J, Weiman D, Abul‐Khoudoud O, Garrett H, Walsh S, Wilson K, Seabrook G, Cambria R, Brown K, Lewis B, Framberg S, Kallio C, Barke R, Santilli S, d'Audiffret A, Oberle N, Proebstle C, Johnson L, Jacobowitz G, Cayne N, Rockman C, Adelman M, Gagne P, Nalbandian M, Caropolo L, Pipinos I, Johanning J, Lynch T, DeSpiegelaere H, Purviance G, Zhou W, Dalman R, Lee J, Safadi B, Coogan S, Wren S, Bahmani D, Maples D, Thunen S, Golden M, Mitchell M, Fairman R, Reinhardt S, Wilson M, Tzeng E, Muluk S, Peterson N, Foster M, Edwards J, Moneta G, Landry G, Taylor L, Yeager R, Cannady E, Treiman G, Hatton‐Ward S, Salabsky T, Kansal N, Owens E, Estes M, Forbes B, Sobotta C, Rapp J, Reilly L, Perez S, Yan K, Sarkar R, Dwyer S, Perez S, Chong K, Kohler T, Hatsukami T, Glickerman D, Sobel M, Burdick T, Pedersen K, Cleary P, Back M, Bandyk D, Johnson B, Shames M, Reinhard R, Thomas S, Hunter G, Leon L, Westerband A, Guerra R, Riveros M, Mills J, Hughes J, Escalante A, Psalms S, Day N, Macsata R, Sidawy A, Weiswasser J, Arora S, Jasper B, Dardik A, Gahtan V, Muhs B, Sumpio B, Gusberg R, Spector M, Pollak J, Aruny J, Kelly E, Wong J, Vasilas P, Joncas C, Gelabert H, DeVirgillio C, Rigberg D, Cole L, Becquemin J, Marzelle J, Becquemin J, Sapoval M, Becquemin J, Favre J, Watelet J, Lermusiaux P, Sapoval M, Lepage E, Hemery F, Dolbeau G, Hawajry N, Cunin P, Harris P, Stockx L, Chatellier G, Mialhe C, Fiessinger J, Pagny L, Kobeiter H, Boissier C, Lacroix P, Ledru F, Pinot J, Deux J, Tzvetkov B, Duvaldestin P, Watelet J, Jourdain C, David V, Enouf D, Ady N, Krimi A, Boudjema N, Jousset Y, Enon B, Blin V, Picquet J, L'Hoste P, Thouveny F, Borie H, Kowarski S, Pernes J, Auguste M, Becquemin J, Desgranges P, Allaire E, Marzelle J, Kobeiter H, Meaulle P, Chaix D, Juliae P, Fabiani J, Chevalier P, Combes M, Seguin A, Belhomme D, Sapoval M, Baque J, Pellerin O, Favre J, Barral X, Veyret C, Watelet J, Peillon C, Plissonier D, Thomas P, Clavier E, Lermusiaux P, Martinez R, Bleuet F, C D, Verhoye J, Langanay T, Heautot J, Koussa M, Haulon S, Halna P, Destrieux L, Lions C, Wiloteaux S, Beregi J, Bergeron P, Pinot J, Patra P, Costargent A, Chaillou P, D'Alicourt A, Goueffic Y, Cheysson E, Parrot A, Garance P, Demon A, Tyazi A, Pillet J, Lescalie F, Tilly G, Steinmetz E, Favier C, Brenot R, Krause D, Cercueil J, Vahdat O, Sauer M, Soula P, Querian A, Garcia O, Levade M, Colombier D, Cardon J, Joyeux A, Borrelly P, Dogas G, Magnan P, Branchereau A, Bartoli J, Hassen‐Khodja R, Batt M, Planchard P, Bouillanne P, Haudebourg P, Bayne J, Gouny P, Badra A, Braesco J, Nonent M, Lucas A, Cardon A, Kerdiles Y, Rolland Y, Kassab M, Brillu C, Goubault F, Tailboux L, Darrieux H, Briand O, Maillard J, Varty K, Cousins C. Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. British Journal Of Surgery 2017, 104: 166-178. PMID: 28160528, PMCID: PMC5299468, DOI: 10.1002/bjs.10430.Peer-Reviewed Original ResearchConceptsElective endovascular aneurysm repairEarly survival advantageEVAR groupOpen repairIndividual patient dataAbdominal aortic aneurysmSurvival advantageEVAR-1Artery diseaseAortic aneurysmPrevious coronary artery diseaseBrachial pressure indexModerate renal dysfunctionPeripheral artery diseaseCoronary artery diseaseEndovascular aneurysm repairPrespecified analysis planOperative mortalityRenal dysfunctionAneurysm repairEarly mortalityACE trialLower ankleLower mortalityMortality advantage
2016
Long-term Cost-effectiveness in the Veterans Affairs Open vs Endovascular Repair Study of Aortic Abdominal Aneurysm: A Randomized Clinical Trial
Lederle FA, Stroupe KT, Kyriakides TC, Ge L, Freischlag JA. Long-term Cost-effectiveness in the Veterans Affairs Open vs Endovascular Repair Study of Aortic Abdominal Aneurysm: A Randomized Clinical Trial. JAMA Surgery 2016, 151: 1139-1144. PMID: 27627802, DOI: 10.1001/jamasurg.2016.2783.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmOpen repair groupEndovascular repairHealth care costsClinical trialsEndovascular groupRepair groupTotal mean health care costsCare costsVeterans Affairs Medical CenterMean health care costsEndovascular repair proceduresInitial endovascular repairAortic abdominal aneurysmQuality of lifeHealth care servicesElective repairClinical outcomesInitial repairShorter hospitalizationAbdominal aneurysmSecondary proceduresAortic aneurysmMAIN OUTCOMEMedical Center
2015
Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of Abdominal Aortic Aneurysms
Lal BK, Zhou W, Li Z, Kyriakides T, Matsumura J, Lederle FA, Freischlag J, Group O. Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of Abdominal Aortic Aneurysms. Journal Of Vascular Surgery 2015, 62: 1394-1404. PMID: 26598115, DOI: 10.1016/j.jvs.2015.02.003.Peer-Reviewed Original ResearchConceptsType II endoleakEndovascular repairSecondary interventionsAortic aneurysmRisk factorsAneurysm sizeVeterans AffairsKaplan-Meier survival analysisInitial aneurysm sizeStandard-risk patientsSuccessful endovascular repairType of endoleakVascular risk factorsInfrarenal aortic aneurysmLong-term outcomesAnalysis of patientsLength of survivalAbdominal aortic aneurysmPresence of endoleaksLogistic regression analysisDiameter enlargementOVER trialPatient demographicsEndoleak developmentLong follow
2012
Long-Term Comparison of Endovascular and Open Repair of Abdominal Aortic Aneurysm
Lederle FA, Freischlag JA, Kyriakides TC, Matsumura JS, Padberg FT, Kohler TR, Kougias P, Jean-Claude JM, Cikrit DF, Swanson KM. Long-Term Comparison of Endovascular and Open Repair of Abdominal Aortic Aneurysm. New England Journal Of Medicine 2012, 367: 1988-1997. PMID: 23171095, DOI: 10.1056/nejmoa1207481.Peer-Reviewed Original ResearchConceptsEndovascular repair groupOpen repair groupAbdominal aortic aneurysmYears of ageEndovascular repairOpen repairLong-term survivalAortic aneurysmSimilar long-term survivalAsymptomatic abdominal aortic aneurysmVeterans Affairs Medical CenterElective endovascular repairLong-term morbidityTraditional open repairType of treatmentCause mortalityPerioperative mortalityTime of registrationOlder patientsYounger patientsEndovascular approachPrimary outcomeAneurysm ruptureMedical CenterSurvival advantage
2009
Outcomes Following Endovascular vs Open Repair of Abdominal Aortic Aneurysm: A Randomized Trial
Lederle FA, Freischlag JA, Kyriakides TC, Padberg FT, Matsumura JS, Kohler TR, Lin PH, Jean-Claude JM, Cikrit DF, Swanson KM, Peduzzi PN, Group F. Outcomes Following Endovascular vs Open Repair of Abdominal Aortic Aneurysm: A Randomized Trial. JAMA 2009, 302: 1535-1542. PMID: 19826022, DOI: 10.1001/jama.2009.1426.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic Aneurysm, AbdominalBlood Vessel Prosthesis ImplantationCatheterization, PeripheralErectile DysfunctionFemaleHumansKaplan-Meier EstimateLength of StayMaleMiddle AgedMinimally Invasive Surgical ProceduresMorbidityPostoperative ComplicationsProportional Hazards ModelsQuality of LifeConceptsAbdominal aortic aneurysmOpen repairShort-term outcomesEndovascular repairPerioperative mortalityMajor morbidityAortic aneurysmProcedure failureTherapeutic proceduresIntensive care unit stayLong-term outcome dataVeterans Affairs Medical CenterElective endovascular repairEndovascular repair groupHealth-related qualityTraditional open repairElective AAA repairMedian procedure timeLength of stayMulticenter clinical trialQuality of lifeElective endovascularTransfusion requirementsUnit stayHospital stay
2008
Early Postoperative Hemorrhage After Open and Laparoscopic Roux-En-Y Gastric Bypass
Bakhos C, Alkhoury F, Kyriakides T, Reinhold R, Nadzam G. Early Postoperative Hemorrhage After Open and Laparoscopic Roux-En-Y Gastric Bypass. Obesity Surgery 2008, 19: 153-157. PMID: 18629595, DOI: 10.1007/s11695-008-9580-1.Peer-Reviewed Original ResearchConceptsLow molecular weight heparinPostoperative hemorrhageGastric bypassHospital staySurgical reexplorationLaparoscopic Roux-EnPostoperative blood transfusionResultsThirty-three patientsLonger hospital stayY Gastric BypassIncidence of hemorrhageMolecular weight heparinTechnical risk factorsLaparoscopic groupPreoperative administrationBleeding groupOpen RouxPostoperative administrationRoux-enEarly hemorrhageInfrequent complicationAverage BMIBlood transfusionLaparoscopic approachClinical presentation
2006
Vital Capacity as a Predictor of Outcome in Elderly Patients with Rib Fractures
Bakhos C, O’Connor J, Kyriakides T, Abou-Nukta F, Bonadies J. Vital Capacity as a Predictor of Outcome in Elderly Patients with Rib Fractures. Journal Of Trauma And Acute Care Surgery 2006, 61: 131-134. PMID: 16832260, DOI: 10.1097/01.ta.0000223463.88422.6a.Peer-Reviewed Original ResearchConceptsRib fracturesPulmonary complicationsElderly patientsVital capacityIntensive care unit lengthBlunt chest trauma patientsEmergency department evaluationChest trauma patientsFurther prospective studiesExtended care facilitiesPredictors of outcomeVital capacity measurementsHospital lengthICU LOSDischarge dispositionDepartment evaluationMean ISSTrauma patientsProspective studyRetrospective studyMean ageStudy criteriaMean VCSingle deathCare facilities
2002
Surveillance of HIV in the army of the Republic of Cyprus (SHARC); rationale, design, and implementation of an inexpensive system
Kyriakides T, Eleftheriou A, Michaelides N, Papantoniou L. Surveillance of HIV in the army of the Republic of Cyprus (SHARC); rationale, design, and implementation of an inexpensive system. Sexually Transmitted Infections 2002, 78: 50. PMID: 11872860, PMCID: PMC1763710, DOI: 10.1136/sti.78.1.50.Peer-Reviewed Original ResearchConceptsCross-sectional prevalence surveyResidual bloodSurveillance of HIVHIV Surveillance SystemHIV infection ratesABO blood groupHepatitis testingUseful epidemiological informationHIV incidenceHIV surveysInfection surveillanceHIV epidemicPrevalence surveyInfection ratePrevalence dataEpidemiological informationSurveillance projectBlood groupBloodSurveillance systemSurveillanceHIVPrevalenceIncidenceIntake