Elevated Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Relate to Muscle Disease Progress
Koutsoulidou A, Kyriakides TC, Papadimas GK, Christou Y, Kararizou E, Papanicolaou EZ, Phylactou LA. Elevated Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Relate to Muscle Disease Progress. PLOS ONE 2015, 10: e0125341. PMID: 25915631, PMCID: PMC4411125, DOI: 10.1371/journal.pone.0125341.Peer-Reviewed Original ResearchConceptsDM1 patientsMuscle-specific miRNAsMuscle wastingNatural historySensitive blood biomarkersPotential future therapiesDisease natural historyMyotonic dystrophy patientsAdult-onset muscular dystrophyMyotonic dystrophy type 1Useful molecular biomarkersParticipant seraSerum levelsMuscle weaknessBlood biomarkersClinical conditionsMuscle atrophyFuture therapiesPatientsPotential biomarkersDystrophy patientsMiR-133aType 1Progressive muscleMolecular biomarkers