2022
Platelet in thrombo-inflammation: Unraveling new therapeutic targets
Sharma S, Tyagi T, Antoniak S. Platelet in thrombo-inflammation: Unraveling new therapeutic targets. Frontiers In Immunology 2022, 13: 1039843. PMID: 36451834, PMCID: PMC9702553, DOI: 10.3389/fimmu.2022.1039843.Peer-Reviewed Original ResearchMeSH KeywordsBlood PlateletsCOVID-19Endothelial CellsFemaleHumansInflammationIschemic StrokePregnancyConceptsRole of plateletsViral infectionPlatelet activationCoagulation pathwayThrombo-inflammatory disordersAcute ischemic strokeContribution of plateletsAnti-inflammatory potentialThrombo-inflammatory diseasesCoronavirus disease 2019Sickle cell diseaseNon-pathologic conditionsNew therapeutic targetsRecruitment of leukocytesPathologic platelet activationPlatelet surface receptorsFormation of thrombiInitial platelet activationSuperficial thrombophlebitisAntiphospholipid syndromeIschemic strokeMicrovascular thrombosisClinical manifestationsInflammatory processCell disease
2019
Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains
Prabhakar A, Chatterjee T, Bajaj N, Tyagi T, Sahu A, Gupta N, Kumari B, Nair V, Kumar B, Ashraf MZ. Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains. Blood Advances 2019, 3: 3713-3723. PMID: 31765479, PMCID: PMC6880906, DOI: 10.1182/bloodadvances.2018024554.Peer-Reviewed Original ResearchConceptsVenous thromboembolismAdhesion molecule-1VTE patientsHA exposureMolecule-1Vascular cell adhesion molecule-1Toll-like receptor 2Intracellular adhesion molecule-1Receiver operator characteristic curve analysisCell adhesion molecule-1Operator characteristic curve analysisMost VTEElevated platelet countVascular endothelial growth factorCharacteristic curve analysisYounger age groupsPlatelet factor 4Endothelial growth factorDistinct biochemical profilesVon Willebrand factorAltered coagulationVTE eventsVenous thrombosisEndothelial activationPlatelet count