2022
Unfolded Protein Response Differentially Modulates the Platelet Phenotype
Jain K, Tyagi T, Du J, Hu X, Patell K, Martin KA, Hwa J. Unfolded Protein Response Differentially Modulates the Platelet Phenotype. Circulation Research 2022, 131: 290-307. PMID: 35862006, PMCID: PMC9357223, DOI: 10.1161/circresaha.121.320530.Peer-Reviewed Original ResearchConceptsUPR pathwayProtein responseMouse plateletsUnfolded protein responseActivation of UPRPlatelet phenotypeTranscriptional regulationGenomic regulationProtein misfoldingAnucleate plateletsProtein aggregationUPR activationPhosphorylation of PLCγ2Chemical chaperonesXBP1 pathwayP38 MAPKPERK pathwayUPRPKCδ activationPlatelet physiologyActivation pathwayPathwayPhenotypeIRE1α inhibitionSelective induction
2019
Role of Platelet Mitochondria: Life in a Nucleus-Free Zone
Melchinger H, Jain K, Tyagi T, Hwa J. Role of Platelet Mitochondria: Life in a Nucleus-Free Zone. Frontiers In Cardiovascular Medicine 2019, 6: 153. PMID: 31737646, PMCID: PMC6828734, DOI: 10.3389/fcvm.2019.00153.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTranscriptional regulationAvian thrombocytesMammalian plateletsMorphological flexibilityAerobic respirationStress responseMitochondriaPlatelet mitochondriaMitochondria damageProtein expressionCritical roleMetabolic substratesPlatelet lifespanKey roleInjury responseCirculating cellsPathophysiological roleNucleusCellsOrganellesRoleRNAStressSurvivalRegulation