2019
Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging
Seli E, Wang T, Horvath TL. Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertility And Sterility 2019, 111: 197-204. PMID: 30691623, DOI: 10.1016/j.fertnstert.2018.11.048.Peer-Reviewed Original ResearchConceptsMitochondrial unfolded protein responseTwo-cell embryo developmentUnfolded protein responseImpaired oocyte maturationMorphology of mitochondriaMitochondrial dysfunction resultsPremature reproductive agingNovel mechanistic insightsMitochondrial DNA contentReactive oxygen species productionPrevention of agingCLPP resultsProtein responseOxygen species productionReproductive agingPreimplantation embryosAge-related accumulationOxidative phosphorylationStress responseEmbryo developmentForm blastocystsMitochondrial functionMitochondriaMitochondrial dysfunctionEnergy metabolism
2008
Cross-talk between estrogen and leptin signaling in the hypothalamus
Gao Q, Horvath TL. Cross-talk between estrogen and leptin signaling in the hypothalamus. AJP Endocrinology And Metabolism 2008, 294: e817-e826. PMID: 18334610, DOI: 10.1152/ajpendo.00733.2007.Peer-Reviewed Original ResearchConceptsAdipocyte-secreted hormone leptinGonadal steroid hormone estrogenAction of leptinMajor risk factorNeuroendocrine reproductive axisEnergy expenditureHalf of adultsSteroid hormone estrogenEnhanced food intakeFunction of estrogenEstrogen deficiencyRisk factorsHormone leptinCardiovascular diseaseHormone estrogenFood intakeBody fatReproductive axisLeptinEstrogenRegulation of reproductionEnergy homeostasisWeight gainEstrogen facilitatesNeuroendocrine processes