2004
Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL. Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin. Science 2004, 304: 110-115. PMID: 15064421, DOI: 10.1126/science.1089459.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArcuate Nucleus of HypothalamusBody WeightEatingEvoked PotentialsExcitatory Postsynaptic PotentialsFeeding BehaviorGamma-Aminobutyric AcidGhrelinGlutamic AcidGreen Fluorescent ProteinsIn Vitro TechniquesLeptinLuminescent ProteinsMiceMice, ObeseMice, TransgenicNeuronal PlasticityNeuronsNeuropeptide YPatch-Clamp TechniquesPeptide HormonesPro-OpiomelanocortinRecombinant Fusion ProteinsSynapsesTetrodotoxinTransgenesConceptsProopiomelanocortin neuronsNeuropeptide YFat-derived hormone leptinBehavioral effectsOb/ob miceLeptin-deficient miceOb/obHypothalamic arcuate nucleusWild-type miceNumber of excitatoryArcuate nucleusLeptin effectsPostsynaptic currentsOb miceHormone leptinSynaptic densityInhibitory synapsesFood intakeNeuronal typesLeptinMiceNeuronsFeeding circuitRapid rewiringHours
2001
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley M, Smart J, Rubinstein M, Cerdán M, Diano S, Horvath T, Cone R, Low M. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001, 411: 480-484. PMID: 11373681, DOI: 10.1038/35078085.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedAnorexiaArcuate Nucleus of HypothalamusElectrophysiologyEvoked PotentialsGamma-Aminobutyric AcidGreen Fluorescent ProteinsLeptinLuminescent ProteinsMaleMiceMice, Inbred C57BLNerve NetNeural InhibitionNeuronsNeuropeptide YPro-OpiomelanocortinConceptsAnorexigenic POMC neuronsPOMC neuronsArcuate nucleusLeptin actionLeptin-deficient humansLepob/Lepob miceLeptin receptor expressionLong-term energy balanceNonspecific cation channelGABA neuronsOrexigenic neuropeptidesObese humansAdipocyte hormoneNeuropeptide YLeptin resistanceElevated leptinReceptor expressionLepob miceMelanocortin peptidesTransgenic miceLeptinAction potentialsNeuropeptide modulatorsCommon obesityElectrophysiological recordings