2006
Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake
Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake. Neuron 2006, 51: 239-249. PMID: 16846858, DOI: 10.1016/j.neuron.2006.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEatingElectric StimulationMaleMiceMice, Inbred AMice, Inbred C57BLMice, KnockoutMice, ObeseMice, TransgenicNerve NetNeuronsPyridinesReceptor, Melanocortin, Type 3Receptor, Melanocortin, Type 4Receptor, Serotonin, 5-HT1BReceptors, MelanocortinSerotoninSerotonin 5-HT1 Receptor AgonistsConceptsFood intakePeripheral adiposity signalsBody weight homeostasisCentral serotonergic systemMelanocortin receptor agonistModulates food intakeSerotonin1B receptorsMelanocortin neuronsWeight homeostasisMelanocortin-3Receptor agonistSerotonergic regulationAdiposity signalsSerotonergic systemEndogenous releaseMelanocortin-4Central circuitryBody weightNeural pathwaysMelanocortin receptorsReceptorsDownstream activationAgonistsAntagonistIntake
2001
Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective.
Horvath T, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective. Endocrinology 2001, 142: 4163-9. PMID: 11564668, DOI: 10.1210/endo.142.10.8490.Peer-Reviewed Original ResearchConceptsGH secretionSynthetic ghrelin receptor agonistEnergy homeostasisGhrelin receptor agonistRole of ghrelinEtiology of obesityLeptin actionReceptor agonistClinical trialsChronic changesCentral regulationNeuroendocrine networkGhrelinNutritional stateEnergy deficitImportant regulatorStomachSecretionRecent findingsHomeostasisMost studiesCachexiaObesityHypothalamusPotential significanceA GABA-neuropeptide Y (NPY) interplay in LH release
Horvath T, Pu S, Dube M, Diano S, Kalra S. A GABA-neuropeptide Y (NPY) interplay in LH release. Peptides 2001, 22: 473-481. PMID: 11287104, DOI: 10.1016/s0196-9781(01)00343-6.Peer-Reviewed Original ResearchConceptsGamma-amino butyric acidLH releaseNeurotransmitter/neuromodulatorExcitatory effectsArcuate nucleusReceptor agonistInhibitory gamma-amino butyric acidY4 receptor agonistRelease of LHImmunoreactive axon terminalsRat brain sectionsDose-dependent mannerOvarian steroidsOvariectomized ratsAxon terminalsBrain sectionsPrimary siteNPYMorphological findingsCyclic releaseAgonistsLHNeuromodulatorsRatsAdministration
1999
Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis.
Pu S, Jain M, Horvath T, Diano S, Kalra P, Kalra S. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology 1999, 140: 933-40. PMID: 9927326, DOI: 10.1210/endo.140.2.6495.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidStimulation of feedingNeuropeptide YParaventricular nucleusFood intakeArcuate nucleusDose-related fashionEffects of muscimolFeeding responseRat brain sectionsNPY actionNPY terminalsNPY neuronsBrain stemHypothalamic controlReceptor agonistSecond messenger systemsSated ratsAxon terminalsBrain sectionsMagnocellular divisionMuscimolMorphological findingsPharmacological analysisDistinct receptors