2014
Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes
Steiner J, Martins-de-Souza D, Schiltz K, Sarnyai Z, Westphal S, Isermann B, Dobrowolny H, Turck CW, Bogerts B, Bernstein HG, Horvath TL, Schild L, Keilhoff G. Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes. Frontiers In Cellular Neuroscience 2014, 8: 384. PMID: 25477781, PMCID: PMC4235405, DOI: 10.3389/fncel.2014.00384.Peer-Reviewed Original ResearchMyelin lipid synthesisMetabolic side effectsAdverse metabolic effectsEffects of clozapineHigh extracellular levelsOLN-93 oligodendrocytesRelease of lactateExpression of galactocerebrosideWhite matter integrityExpression of glucoseLipid synthesisOligodendrocyte dysfunctionFree fatty acidsLactate levelsMetabolic effectsGlucose metabolismSide effectsSchizophrenia therapyExtracellular levelsMyelin lipid metabolismClozapineLipid metabolismHaloperidolGlucose uptakeOligodendrocytes
2012
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes
Fuente-Martín E, García-Cáceres C, Granado M, de Ceballos ML, Sánchez-Garrido MÁ, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizón P, Díaz F, Argente J, Horvath TL, Chowen JA. Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. Journal Of Clinical Investigation 2012, 122: 3900-3913. PMID: 23064363, PMCID: PMC3484452, DOI: 10.1172/jci64102.Peer-Reviewed Original ResearchConceptsGlial structural proteinsPathology of obesityHypothalamic proopiomelanocortin (POMC) neuronsGlial cell activityOffspring of mothersHigh-fat dietActivity of neuronsExpression of glucoseProopiomelanocortin neuronsHypothalamic astrocytesGlial cellsBody weightSynaptic efficacyGlutamate transportersNeuronal functionCell activityLeptinGlucose uptakeMetabolic statusElectrical activityMetabolic signalsNeuronsAppetiteGlucose transporterKey regulator