Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism
Kim KE, Jung Y, Min S, Nam M, Heo RW, Jeon BT, Song DH, Yi CO, Jeong EA, Kim H, Kim J, Jeong SY, Kwak W, Ryu do H, Horvath TL, Roh GS, Hwang GS. Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism. Scientific Reports 2016, 6: 30111. PMID: 27439777, PMCID: PMC4954985, DOI: 10.1038/srep30111.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseDb/db miceDb miceEffects of CRCaloric restrictionLiver diseaseHepatic steatosisHepatic metabolismObese diabetic db/db miceBody weightDiabetic db/db miceFatty liver diseaseObesity-related diseasesInflammation-related proteinsSignificant metabolic alterationsMultiple pathological mechanismsEndoplasmic reticulum stressWestern blot analysisMultiple complicationsInsulin resistanceLipocalin-2Metabolic dysfunctionTherapeutic effectFrequent causeClinical problemProlongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
Youm YH, Horvath TL, Mangelsdorf DJ, Kliewer SA, Dixit VD. Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 1026-1031. PMID: 26755598, PMCID: PMC4743827, DOI: 10.1073/pnas.1514511113.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationAge-related thymic involutionCaloric restrictionFGF21 functionThymic involutionThymic agingHormone fibroblast growth factor 21Peripheral T-cell diversityThymic T-cell exportFibroblast growth factor 21Diverse T cell repertoireCortical thymic epithelial cellsLow immune competenceT cell frequenciesStem cell transplantationGrowth factor 21Naïve T cellsMiddle-aged miceT cell repertoireT cell diversityThymic stromal cellsT cell exportThymic epithelial cellsBrown adipose tissueEarly thymocyte progenitors