2024
High-resolution brain phantom data, with flexible contrast: Validation on the NeuroExplorer (NX)
Gravel P, Toyonaga T, Gallezot J, Fontaine K, Martins S, Mulnix T, Carson R. High-resolution brain phantom data, with flexible contrast: Validation on the NeuroExplorer (NX). 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10656366.Peer-Reviewed Original ResearchQuantitative accuracyPhantom dataSpatial resolutionIterative reconstruction algorithmListmode dataAttenuation correctionPhantom studyPhantomResolution measurementsAttenuation propertiesReconstructed imagesReconstruction algorithmPET imagingCorrection accuracyResolutionScatteringAxial directionAttenuationContrastCorrectionAdaptive Deep Image Prior Enhances Ultra-Low Dose PET Imaging with NeuroEXPLORER
Li A, Gravel P, Gallezot J, Toyonaga T, Fontaine K, Carson R, Tang J. Adaptive Deep Image Prior Enhances Ultra-Low Dose PET Imaging with NeuroEXPLORER. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10657691.Peer-Reviewed Original ResearchContrast recovery coefficientCounting imagingLearning-based denoising methodsHead motion correctionDeep Image PriorLow-dose imagesOptimal stopping iterationsDose imagesAttenuation mapBrain phantomDeep imagingFull-count dataImage priorsMotion correctionSignal-to-noise ratioDenoising methodSequence of outputsTraining dataPET imagingStopping iterationDecreased signal-to-noise ratioNoise ratioPost-processing techniquesReconstructed imagesRecovery coefficientGeneration of Synthetic brain PET images of synaptic density from MRI and FDG-PET using a Multi-stage U-Net
Zheng X, Worhunsky P, Liu Q, Zhou B, Chen X, Guo X, Xie H, Sun H, Zhang J, Toyonaga T, Mecca A, O’Dell R, van Dyck C, Carson R, Radhakrishnan R, Liu C. Generation of Synthetic brain PET images of synaptic density from MRI and FDG-PET using a Multi-stage U-Net. 2024, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57108.2024.10655600.Peer-Reviewed Original ResearchPOUR-Net: A Population-Prior-Aided Over-Under-Representation Network for Low-Count PET Attenuation Map Generation
Zhou B, Hou J, Chen T, Zhou Y, Chen X, Xie H, Liu Q, Guo X, Xia M, Tsai Y, Panin V, Toyonaga T, Duncan J, Liu C. POUR-Net: A Population-Prior-Aided Over-Under-Representation Network for Low-Count PET Attenuation Map Generation. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10658051.Peer-Reviewed Original ResearchPET attenuation correctionLow-dose PETAttenuation correctionU-mapAttenuation mapElevated radiation doseRadiation doseEfficient feature extractionRadiation exposurePET imagingFinely detailed featuresBaseline methodsMitigate radiation exposureFeature extractionCorrectionMap generationGeneration machinesAn Investigation on Cross-Tracer Generalizability of Deep Learning-based PET Attenuation Correction
Hou J, Chen T, Zhou Y, Chen X, Xie H, Liu Q, Xia M, Panin V, Liu C, Zhou B, Toyonaga T. An Investigation on Cross-Tracer Generalizability of Deep Learning-based PET Attenuation Correction. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10657095.Peer-Reviewed Original ResearchAttenuation correctionPET attenuation correctionQuantitative PET imagingAttenuation mapDL modelsDeep learning (DL)-based methodsTumor quantificationDL model trainingRadiation doseImmediate future workCompetitive performancePET imagingModel trainingPET signalCorrectionAnalysis of PETFuture workPreliminary resultsData availabilityRadiation
2022
PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging
Toyonaga T, Fesharaki-Zadeh A, Strittmatter SM, Carson RE, Cai Z. PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging. Frontiers In Neuroscience 2022, 16: 787404. PMID: 35345546, PMCID: PMC8957200, DOI: 10.3389/fnins.2022.787404.Peer-Reviewed Original ResearchAnimal modelsPET imaging studiesPET imagingImaging studiesSynaptic vesicle glycoprotein 2ADisease animal modelsOngoing clinical investigationsDifferent injection routesSynaptic densityClinical investigationPharmacological effectsRodent brainNovel interventionsInjection routeNeurodegenerative disordersNeuropsychiatric diseasesPET studiesBrainMultiple diseasesPET centersDiseaseInjectable volumeImagingSmaller brainsPET
2020
PET Imaging of Synaptic Vesicle Protein 2A
Finnema S, Li S, Cai Z, Naganawa M, Chen M, Matuskey D, Nabulsi N, Esterlis I, Holmes S, Radhakrishnan R, Toyonaga T, Huang Y, Carson R. PET Imaging of Synaptic Vesicle Protein 2A. 2020, 993-1019. DOI: 10.1007/978-3-030-53176-8_29.ChaptersSynaptic vesicle protein 2APositron emission tomographyAntiepileptic drug levetiracetamInitial PET studiesPET imagingPET studiesSynaptic densityDrug levetiracetamHigh-affinity SV2A ligandsBrain regionsSynaptic density lossNeuropathological diseasesDisease-modifying therapiesLarge patient cohortMajor depressive disorderProtein 2APET imaging resultsPosttraumatic stress disorderPatient groupPatient cohortDepressive disorderClinical valueParkinson's diseaseEfficacy assessmentSynaptic vesicle proteins