2024
Variability in Constituents of E-Cigarette Products Containing Nicotine Analogues
Erythropel H, Jabba S, Silinski P, Anastas P, Krishnan-Sarin S, Zimmerman J, Jordt S. Variability in Constituents of E-Cigarette Products Containing Nicotine Analogues. JAMA 2024, 332: 753-755. PMID: 39110443, PMCID: PMC11307159, DOI: 10.1001/jama.2024.12408.Peer-Reviewed Original ResearchMarketing of nicotinamide as nicotine replacement in electronic cigarettes and smokeless tobacco
Jabba S, Jordt S. Marketing of nicotinamide as nicotine replacement in electronic cigarettes and smokeless tobacco. Tobacco Prevention & Cessation 2024, 10: 1-5. PMID: 39132445, PMCID: PMC11295357, DOI: 10.18332/tpc/187767.Peer-Reviewed Original ResearchAn Electronic Cigarette Pod System Delivering 6-methyl Nicotine, A Synthetic Nicotine Analog, Marketed in the United States as "PMTA Exempt"
Jordt S, Silinski P, Berman M. An Electronic Cigarette Pod System Delivering 6-methyl Nicotine, A Synthetic Nicotine Analog, Marketed in the United States as "PMTA Exempt". 2024, a2135-a2135. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2135.Peer-Reviewed Original ResearchSpree Bar, a vaping system delivering a synthetic nicotine analogue, marketed in the USA as ‘PMTA exempt’
Jordt S, Jabba S, Zettler P, Berman M. Spree Bar, a vaping system delivering a synthetic nicotine analogue, marketed in the USA as ‘PMTA exempt’. Tobacco Control 2024, tc-2023-058469. PMID: 38499343, PMCID: PMC11408701, DOI: 10.1136/tc-2023-058469.Peer-Reviewed Original ResearchVagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice
Wu P, Caceres A, Chen J, Sokoloff J, Huang M, Baht G, Nackley A, Jordt S, Terrando N. Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice. Pain 2024, 165: e80-e92. PMID: 38422485, PMCID: PMC11247455, DOI: 10.1097/j.pain.0000000000003181.Peer-Reviewed Original ResearchDorsal root gangliaPostoperative painVagus nerve stimulationPain behaviorOrthopedic surgeryNerve stimulationHindpaw mechanical allodyniaPrevent postoperative painFemale C57BL/6J miceOrthopedic trauma surgeryMechanical allodyniaAntinociceptive effectPersistent painAccelerated bone healingAnalgesic effectAdult miceC57BL/6J miceEffective therapyNeuropeptide levelsSpinal cordMouse modelSatellite cellsSurgeryPainVagus nerveRecapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury
Achanta S, Gentile M, Albert C, Schulte K, Pantazides B, Crow B, Quiñones-González J, Perez J, Ford D, Patel R, Blake T, Gunn M, Jordt S. Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l482-l495. PMID: 38318664, PMCID: PMC11281795, DOI: 10.1152/ajplung.00162.2023.Peer-Reviewed Original ResearchAcute lung injuryBronchoalveolar lavage fluidChlorine gasChlorinated fatty acidsDecreased dynamic lung complianceHuman acute lung injuryPeak inspiratory pressureIncreased airway resistanceMedical countermeasuresControlled mechanical ventilationForensic biomarkersDynamic lung complianceFormation of microthrombiProtein adductsAir-exposed groupNeutrophilic alveolitisTesting medical countermeasuresVascular leakageNeutrophil countPulmonary edemaHistopathological featuresPotential medical countermeasuresForensic analysisInspiratory pressureLung injury
2023
Pharmacologic inhibition of TRPA1 counteract tear gas induced cutaneous injuries
Achanta S, Chintagari N, Balakrishna S, Liu B, Jordt S. Pharmacologic inhibition of TRPA1 counteract tear gas induced cutaneous injuries. Journal Of Pharmacology And Experimental Therapeutics 2023, 388: jpet-ar-2023-001666. PMID: 38050077, PMCID: PMC10801748, DOI: 10.1124/jpet.123.001666.Peer-Reviewed Original ResearchTransient receptor potential ankyrin 1Tear gas agentsCutaneous injurySkin injuryTRPA1 antagonistTRPA1 inhibitor HC-030031Injury parametersWeek old C57BL/6 male miceInflammatory cytokine levelsC57BL/6 male miceTherapeutic efficacy studiesEffects of CSNeuronal ion channelsMouse ear skinTRPA1 inhibitionAirway obstructionNeurogenic inflammationCytokine levelsHC-030031Severe painPlasma extravasationCS exposureAcute irritationAcute toxic effectsFrequent injuriesTransient Receptor Potential channels (TRP) in GtoPdb v.2023.3
Blair N, Caceres A, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jabba S, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.3.Peer-Reviewed Original ResearchTRPC channelsTransient receptor potential channelsCongenital stationary night blindnessCalcium-activated cationStore-operated channelsAdenosine diphosphate riboseNumerous splice variantsNMDA receptorsActivate TRPA1Cation channelsIntracellular ATP levelsChannel activityMicromolar concentrations of La3+Neurodegenerative disorder mucolipidosis type IVDepletion of intracellular calcium storesMucolipidosis type IVTRP channelsRegulation of Ca2+ entryAssociated with conduction defectsDetection of noxious heatDevelopment of heat hyperalgesiaDevelopment of thermal hyperalgesiaDynamic intracellular vesicular structuresExtra-synaptic NMDA receptorsInvolvement of TRP channelsEngland Is Handing out E-Cigarettes: Is the “Swap to Stop” Tobacco Control Scheme Harm Reduction or Harm Production?
Lang A, Kathuria H, Braillon A, Ewart G, Dagli E, Stepp E, Galiatsatos P, Deepak J, Jordt S, Hayes D. England Is Handing out E-Cigarettes: Is the “Swap to Stop” Tobacco Control Scheme Harm Reduction or Harm Production? American Journal Of Respiratory And Critical Care Medicine 2023, 208: 1024-1025. PMID: 37682082, PMCID: PMC10867939, DOI: 10.1164/rccm.202308-1354vp.Peer-Reviewed Original ResearchSynthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans
Jabba S, Erythropel H, Anastas P, Zimmerman J, Jordt S. Synthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans. JAMA 2023, 330: 1689-1691. PMID: 37812408, PMCID: PMC10562986, DOI: 10.1001/jama.2023.17134.Peer-Reviewed Original ResearchThe Concise Guide to PHARMACOLOGY 2023/24: Ion channels
Alexander S, Mathie A, Peters J, Veale E, Striessnig J, Kelly E, Armstrong J, Faccenda E, Harding S, Davies J, Aldrich R, Attali B, Baggetta A, Becirovic E, Biel M, Bill R, Caceres A, Catterall W, Conner A, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fenske S, Fortuny-Gomez A, Fountain S, George C, Goldstein S, Grimm C, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Hu M, Ijzerman A, Jabba S, Jarvis M, Jensen A, Jordt S, Kaczmarek L, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch J, Meades J, Mehlfeld V, Nicke A, Offermanns S, Perez-Reyes E, Plant L, Rash L, Ren D, Salman M, Sieghart W, Sivilotti L, Smart T, Snutch T, Tian J, Trimmer J, Van den Eynde C, Vriens J, Wei A, Winn B, Wulff H, Xu H, Yang F, Fang W, Yue L, Zhang X, Zhu M. The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. British Journal Of Pharmacology 2023, 180: s145-s222. PMID: 38123150, PMCID: PMC11339754, DOI: 10.1111/bph.16178.Peer-Reviewed Original ResearchConceptsBest available pharmacological toolsOpen access knowledgebase sourceOfficial IUPHAR classificationAvailable pharmacological toolsDrug targetsG protein-coupled receptorsIon channelsProtein-coupled receptorsNomenclature guidanceClinical pharmacologyMajor pharmacological targetCatalytic receptorsSelective pharmacologyNuclear hormone receptorsPharmacological targetsPharmacological toolsHormone receptorsPrevious GuidesReceptorsLandscape formatHuman drug targetsPharmacologyConcise guideBiennial publicationRelated targetsSynthetic Nicotine: Science, Global Legal Landscape, and Regulatory Considerations.
Berman M, Zettler P, Jordt S. Synthetic Nicotine: Science, Global Legal Landscape, and Regulatory Considerations. Technical Report Series 930 2023, 1047: 35-60. PMID: 37745838, PMCID: PMC10516533.Peer-Reviewed Original ResearchTransient Receptor Potential channels (TRP) in GtoPdb v.2023.2
Blair N, Caceres A, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jabba S, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.2.Peer-Reviewed Original ResearchTransient receptor potential channelsCongenital stationary night blindnessTRPC channelsAdenosine diphosphate riboseStore-operated channelsMost TRP channelsTRP channelsNMDA receptorsCation channelsIntracellular ATP levelsExtra-synaptic NMDA receptorsMetabotropic glutamate receptor 6Activation of GoHuman TRPM1 mutationsReabsorption of calciumTRPC4/C5Ion channelsExpression of S100A9Dendritic cell migrationBile duct diseaseIntracellular calcium storesActivity of TRPV1Layer 5 neuronsSynaptic NMDA receptorsMouse prefrontal cortexSynthetic cooling agent in oral nicotine pouch products marketed as ‘Flavour-Ban Approved’
Jabba S, Erythropel H, Woodrow J, Anastas P, O'Malley S, Krishnan-Sarin S, Zimmerman J, Jordt S. Synthetic cooling agent in oral nicotine pouch products marketed as ‘Flavour-Ban Approved’. Tobacco Control 2023, tc-2023-058035. PMID: 37380351, PMCID: PMC10753027, DOI: 10.1136/tc-2023-058035.Peer-Reviewed Original ResearchGas chromatography/mass spectrometryChromatography/mass spectrometryWS-3Oral nicotine pouchesSynthetic coolantsMass spectrometryChemical analysisSensory irritancyFlavor additivesAdditivesChemical contentFlavoring agentProductsIrritant activitySpectrometryFlavourantsEffective strategyExtractAgentsNicotine pouchesHigh Toxicity of Cinnamon-flavored Electronic Cigarette Liquids: A Lesson Not Learned
Jordt S, Erythropel H, Zimmerman J, Jabba S. High Toxicity of Cinnamon-flavored Electronic Cigarette Liquids: A Lesson Not Learned. 2023, a2632-a2632. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2632.Peer-Reviewed Original ResearchSynthetic Cooling Agents in California-Marketed "Non-menthol" Cigarette Brands Introduced After the State’s Menthol Ban
Jordt S, Erythropel H, Yang A, O'Malley S, Krishnan-Sarin S, Zimmerman J, Jabba S. Synthetic Cooling Agents in California-Marketed "Non-menthol" Cigarette Brands Introduced After the State’s Menthol Ban. 2023, a2633-a2633. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2633.Peer-Reviewed Original ResearchSoluble Epoxide Hydrolase Inhibitors and ACE Inhibitors Ameliorate Phosgene Inhalation Injuries
Achanta S, Marcus A, Caceres A, Jordt S. Soluble Epoxide Hydrolase Inhibitors and ACE Inhibitors Ameliorate Phosgene Inhalation Injuries. 2023, a1171-a1171. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1171.Peer-Reviewed Original ResearchTransient Receptor Potential channels (TRP) in GtoPdb v.2023.1
Blair N, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.1.Peer-Reviewed Original ResearchTransient receptor potential channelsCongenital stationary night blindnessTRPC channelsAdenosine diphosphate riboseStore-operated channelsMost TRP channelsTRP channelsNMDA receptorsCation channelsIntracellular ATP levelsExtra-synaptic NMDA receptorsMetabotropic glutamate receptor 6Activation of GoHuman TRPM1 mutationsReabsorption of calciumTRPC4/C5Ion channelsExpression of S100A9Dendritic cell migrationBile duct diseaseIntracellular calcium storesActivity of TRPV1Layer 5 neuronsSynaptic NMDA receptorsMouse prefrontal cortexVagus Nerve Stimulation Rescues Persistent Pain Following Orthopedic Surgery In Adult Mice
Wu P, De Caceres A, Baht G, Terrando N, Jordt S. Vagus Nerve Stimulation Rescues Persistent Pain Following Orthopedic Surgery In Adult Mice. Journal Of Pain 2023, 24: 10. DOI: 10.1016/j.jpain.2023.02.044.Peer-Reviewed Original ResearchVagus nerve stimulationPostoperative painOrthopedic surgeryNerve stimulationPain 2 yearsAnti-nociceptive effectsPersistent postoperative painSatellite glial cellsAnti-inflammatory effectsMajor clinical problemBilateral hindTibial surgeryMicroglia activationRisk patientsPain sensitizationPersistent painVagus nervePain behaviorEffective therapyFemale miceSpinal cordWeekly treatmentGlial cellsGFAP expressionInvasive proceduresEffect Of Comt Genetic Background And Stress On Pain Following Tibial Fracture
Chen J, Wu Y, Wang Y, Sandu C, Gu E, Jordt S, Terrando N, Nackley A. Effect Of Comt Genetic Background And Stress On Pain Following Tibial Fracture. Journal Of Pain 2023, 24: 30. DOI: 10.1016/j.jpain.2023.02.098.Peer-Reviewed Original ResearchDepressive-like behaviorStress fracture groupTail suspension testTibial fracturesSham stressAbdominal sitesSuspension testSham–sham groupVon Frey filamentsWild-type miceAbdominal hyperalgesiaMechanical hyperalgesiaMechanical hypersensitivityImmobility timeWT miceBody painType miceHyperalgesiaPainSpinal needleActivity genotypeMonth time periodGenetic inhibitionStress groupCOMT genotype