2024
Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice
Wu P, Caceres A, Chen J, Sokoloff J, Huang M, Baht G, Nackley A, Jordt S, Terrando N. Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice. Pain 2024, 165: e80-e92. PMID: 38422485, PMCID: PMC11247455, DOI: 10.1097/j.pain.0000000000003181.Peer-Reviewed Original ResearchDorsal root gangliaPostoperative painVagus nerve stimulationPain behaviorOrthopedic surgeryNerve stimulationHindpaw mechanical allodyniaPrevent postoperative painFemale C57BL/6J miceOrthopedic trauma surgeryMechanical allodyniaAntinociceptive effectPersistent painAccelerated bone healingAnalgesic effectAdult miceC57BL/6J miceEffective therapyNeuropeptide levelsSpinal cordMouse modelSatellite cellsSurgeryPainVagus nerve
2023
Vagus Nerve Stimulation Rescues Persistent Pain Following Orthopedic Surgery In Adult Mice
Wu P, De Caceres A, Baht G, Terrando N, Jordt S. Vagus Nerve Stimulation Rescues Persistent Pain Following Orthopedic Surgery In Adult Mice. Journal Of Pain 2023, 24: 10. DOI: 10.1016/j.jpain.2023.02.044.Peer-Reviewed Original ResearchVagus nerve stimulationPostoperative painOrthopedic surgeryNerve stimulationPain 2 yearsAnti-nociceptive effectsPersistent postoperative painSatellite glial cellsAnti-inflammatory effectsMajor clinical problemBilateral hindTibial surgeryMicroglia activationRisk patientsPain sensitizationPersistent painVagus nervePain behaviorEffective therapyFemale miceSpinal cordWeekly treatmentGlial cellsGFAP expressionInvasive procedures