2023
Pharmacologic inhibition of TRPA1 counteract tear gas induced cutaneous injuries
Achanta S, Chintagari N, Balakrishna S, Liu B, Jordt S. Pharmacologic inhibition of TRPA1 counteract tear gas induced cutaneous injuries. Journal Of Pharmacology And Experimental Therapeutics 2023, 388: jpet-ar-2023-001666. PMID: 38050077, PMCID: PMC10801748, DOI: 10.1124/jpet.123.001666.Peer-Reviewed Original ResearchTransient receptor potential ankyrin 1Tear gas agentsCutaneous injurySkin injuryTRPA1 antagonistTRPA1 inhibitor HC-030031Injury parametersWeek old C57BL/6 male miceInflammatory cytokine levelsC57BL/6 male miceTherapeutic efficacy studiesEffects of CSNeuronal ion channelsMouse ear skinTRPA1 inhibitionAirway obstructionNeurogenic inflammationCytokine levelsHC-030031Severe painPlasma extravasationCS exposureAcute irritationAcute toxic effectsFrequent injuries
2011
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Willis DN, Liu B, Ha MA, Jordt S, Morris JB. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. The FASEB Journal 2011, 25: 4434-4444. PMID: 21903934, PMCID: PMC3236628, DOI: 10.1096/fj.11-188383.Peer-Reviewed Original ResearchConceptsTransient receptor potential ankyrin 1Irritation responseMenthol effectsCold-sensitive sensory neuronsSensory TRP channelsSmoking-related morbiditySensory irritation responseEffect of mentholTransient receptor potential melastatin 8 (TRPM8) ion channelActivation of TRPM8TRPM8 agonistTRPM8 antagonistsCapsaicin receptorRespiratory tractSensory neuronsAnkyrin 1Pharmacological actionsNicotine addictionSmoking behaviorRespiratory irritationTRP channelsAgonistsSmoke constituentsAvailable cigarettesCigarettes
2009
TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases
Bessac B, Sivula M, von Hehn C, Caceres A, Escalera J, Jordt S. TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases. The FASEB Journal 2009, 23: 580.11-580.11. DOI: 10.1096/fasebj.23.1_supplement.580.11.Peer-Reviewed Original ResearchTransient receptor potential ankyrin 1Tear gas agentsSame neuronal receptorNoxious effectsTear gasesActivation of Ca2Adverse health effectsNocifensive behaviorAirway irritationCutaneous exposureTRPA1 antagonistSensory neuronsAnkyrin 1Neuronal receptorsPharmacological inhibitionGenetic ablationHealth effectsMembrane currentsFrequent exposureNoxious chemicalsExposureIon channelsSimilar responsesCa2Lacrimation