2007
Trp Channels In Disease
JORDT SE, EHRLICH BE. Trp Channels In Disease. Subcellular Biochemistry 2007, 45: 253-271. PMID: 18193640, DOI: 10.1007/978-1-4020-6191-2_9.Peer-Reviewed Original ResearchConceptsTRP channelsTransient receptor potential channelsPainful stimuliTRPA (ankyrin) groupsRole of TrpIntracellular Ca2Intracellular storesTRP channel physiologyDiseaseNormal physiologyChannel physiologySpecific diseasesPathophysiologyPotential channelsDifferent TRPsExtracellular stimuliMain subfamiliesDistinct functionsChemical signalsStimuliPhysiologyLarge familyMutationsProgression
1997
Molecular dissection of gating in the ClC‐2 chloride channel
Jordt S, Jentsch T. Molecular dissection of gating in the ClC‐2 chloride channel. The EMBO Journal 1997, 16: 1582-1592. PMID: 9130703, PMCID: PMC1169762, DOI: 10.1093/emboj/16.7.1582.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell MembraneChloride ChannelsConsensus SequenceHydrogen-Ion ConcentrationIon Channel GatingMembrane PotentialsModels, StructuralMolecular Sequence DataMutagenesis, Site-DirectedOocytesPatch-Clamp TechniquesPoint MutationProtein Structure, SecondaryRatsRecombinant Fusion ProteinsXenopus laevisConceptsChloride channelsClC-2 chloride channelSite-directed mutagenesisMolecular dissectionEquivalent mutationCytoplasmic loopMode of activationClC-0ClC-2Gating mechanismInactivation domainMutationsCell swellingActivationNeuronal excitabilityMutagenesisTransmembraneCell volumeDeletionRegulationPathwayFinal pathwayMechanismVoltage dependenceOutward rectification