2017
Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons
Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg F, Schwede F, Stein C, Jordt S, Brackmann M, Spahn V. Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons. European Journal Of Pain 2017, 21: 1072-1086. PMID: 28182310, PMCID: PMC5504413, DOI: 10.1002/ejp.1008.Peer-Reviewed Original ResearchConceptsAnkyrin-rich membranePKA-dependent mannerKinase DHEK-293 cellsSensitivity of TRPV1Immunoprecipitation experimentsDRG neuronsNovel modulatorRodent DRG neuronsIon channelsIon channel TRPV1Excitatory ion channelSmall-diameter dorsal root ganglion neuronsTransient receptor potential vanilloidImportant componentDorsal root ganglion neuronsPeripheral sensory neuronsMouse DRG neuronsChemical stimuliSensory neuronsCellsComplexesMembraneDirect modificationTRPV1 expression
2006
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents. Cell 2006, 124: 1269-1282. PMID: 16564016, DOI: 10.1016/j.cell.2006.02.023.Peer-Reviewed Original ResearchConceptsTRPA1-deficient miceInflammatory painEnvironmental irritantsInflammatory actionsProalgesic agentsPrimary afferent nociceptorsExcitatory ion channelPain hypersensitivityPungent irritantsAfferent nociceptorsNociceptor excitationAuditory functionThermal nociceptionNoxious coldMice exhibitChemotherapeutic agentsTRPA1PainIrritantsNociceptorsMiceSole targetMustard oilIon channelsInitial detection
2005
Pungent products from garlic activate the sensory ion channel TRPA1
Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM. Pungent products from garlic activate the sensory ion channel TRPA1. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 12248-12252. PMID: 16103371, PMCID: PMC1189336, DOI: 10.1073/pnas.0505356102.Peer-Reviewed Original ResearchConceptsSensory nerve endingsSensory neuronsNerve endingsTRPA1 channelsDiallyl disulfidePrimary sensory neuronsActivation of TRPA1Ion channel TRPA1Excitatory ion channelPain pathwaysPungent ingredientAllium familyVasorelaxant activityTRPA1Health benefitsNeuronsAllium extractsIon channelsAllicinMolecular mechanismsAllyl isothiocyanateEndingsPainVasodilationInflammation