2024
Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury
Achanta S, Gentile M, Albert C, Schulte K, Pantazides B, Crow B, Quiñones-González J, Perez J, Ford D, Patel R, Blake T, Gunn M, Jordt S. Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l482-l495. PMID: 38318664, PMCID: PMC11281795, DOI: 10.1152/ajplung.00162.2023.Peer-Reviewed Original ResearchAcute lung injuryBronchoalveolar lavage fluidChlorine gasChlorinated fatty acidsDecreased dynamic lung complianceHuman acute lung injuryPeak inspiratory pressureIncreased airway resistanceMedical countermeasuresControlled mechanical ventilationForensic biomarkersDynamic lung complianceFormation of microthrombiProtein adductsAir-exposed groupNeutrophilic alveolitisTesting medical countermeasuresVascular leakageNeutrophil countPulmonary edemaHistopathological featuresPotential medical countermeasuresForensic analysisInspiratory pressureLung injury
2019
The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury
Caceres A, Jordt S. The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury. 2019, pa3885. DOI: 10.1183/13993003.congress-2019.pa3885.Peer-Reviewed Original ResearchTRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury
Achanta S, Liu B, Gentile M, Caceres A, Behm D, Burgert M, Costell M, Cheifetz I, Gunn M, Jordt S. TRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury. 2019, a1017-a1017. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1017.Peer-Reviewed Original Research